The reaction of the body of a pregnant woman on a particular drug is unpredictable. This happens because during pregnancy under the influence of hormones in a woman's body changes completely metabolism Improves metabolism and losing weight without dieting . But the most dangerous drug in the first 12 weeks of pregnancy.

Why during pregnancy may need antifungal agents

During pregnancy, a woman causes low immunity. This is a normal reaction to the development of the fetus in it, which is a foreign body in relation to the body of the mother. Immunity is reduced so that the woman can bear a child.

But this reduction is fraught with the development of various infections, especially fungal infections. Yeast fungi of the genus Candida are constantly present on the surface of the genital mucosa of most women. By reducing the immunity they begin to actively proliferate, are introduced into the mucosa and cause disease - vaginal candidiasis or thrush. Constantly recurrent thrush often accompanies pregnant women.

So maybe you should not fight it, because after giving birth, in most cases, thrush goes? The problem is that the yeast may have adverse effects on the fetus. In most cases, the infection can not penetrate the placenta and fetus infection occurs during or after childbirth. A newborn develop candida skin and mucous membranes, which can spread to the internal organs.

Meet and intrauterine infection caused by fungi genus Candida. As a rule, it runs hard. Therefore, pregnant women treat thrush. For this permission applies to pregnant antifungal drugs in the periods of pregnancy, when the impact on the fetus can be minimized

What mikosist and how it works with thrush

Mikosist (active substance - fluconazole) - is an antifungal drug which selectively (selective) effect on cells sensitive fungi thereto: it inhibits the formation of certain vital substances fungal cells, leading to their death.

Mikosist has a broad spectrum antifungal activity, it is active against fungi causing infections in humans such as candidiasis, cryptococcosis, fungal diseases of the skin, including deep mycosis such as mikrosporiya and trichophytia, coccidioidomycosis, paracoccidioidomycosis and histoplasmosis.

Mikosist has a number of side effects and contraindications for use. Because side effects are known: nausea, vomiting, diarrhea, abdominal distension (bloating), abdominal pain Abdominal pain: Types and Symptoms , Liver problems, headaches, dizziness, convulsive readiness, heart rhythm disorders, alopecia (hair loss). It is also possible blood disorders as a decrease in the number of peripheral blood leukocytes and thrombocytes (which may cause immunosuppression and increased bleeding), metabolic disorders (increased blood levels of cholesterol and reducing the potassium content), and allergic reactions.

Contraindications for use Mikosista are individual intolerance of components, feeding baby Breastfeeding - a personal choice   feeding, the simultaneous use of drugs that could affect the heart rhythm (eg, antihistamines terfenadine and astemizole).

Requires careful when appointing Mikosista for violations of liver and kidney function, heart rhythm disturbances and pregnancy.

As mikosist acts on the body of a pregnant woman

As mikosist will affect a pregnant woman and the fetus is difficult to predict, since clinical trials Mikosista in this cohort of patients have not been conducted. Laboratory studies in animals showed no teratogenic (fetal anomalies) and embryotoxic effects of the drug on the fetus.

But in medical practice there were cases of teratogenicity active principle Mikosista fluconazole. This action is manifested in the form of congenital malformations in the fetus of a pregnant woman at the reception for a few months in the high-dose fluconazole for severe fungal diseases. Yet the proven link between abnormalities of fetal development and administration of fluconazole has not been revealed.

Therefore mikosist can be used to treat pregnant women only when the intended benefits to the mother's body than the potential harm to the fetus. For example, in generalized fungal infections, fungal meningitis, visceral, when there is a direct threat to the life of the pregnant woman.

When lung fungal diseases (for example, vaginal candidiasis) pregnant women prescribed drugs permitted for use during pregnancy, for example, pimafutsin Pimafucin - help in difficult times .

But in any case, even the most harmless antifungal agents pregnant women have the right to appoint a doctor.

Galina Romanenko

Adenomyosis - a disorder in which the endometrium, or uterine lining begins to grow into the uterine wall. Although currently adenomyosis diagnosed in an increasing number of women - it is especially common among those who suffer from endometriosis - is still unclear how great the probability that a violation will cause infertility and whether it is possible to get pregnant adenomyosis.

The reasons for adenomyosis may be a genetic predisposition, overweight and obesity, surgery on the uterus (including abortion), heavy physical labor, poor environmental conditions, lack of exercise, combined oral contraceptives, frequent stress, and so on.

Research

The first results obtained from research data that adenomyosis can cause infertility, related to 2004. Then a report was published about the study the health status of living in zoos baboons: it was found that animals suffer from adenomyosis, are more likely to become infertile. Researchers concluded that adenomyosis is closely associated with primary infertility in baboons, including those who have not been diagnosed endometriosis. In the same year, a group of scientists conducted a thorough examination of forty women with symptomatic endometriosis. With the help of MRI (magnetic resonance imaging), adenomyosis was diagnosed in 85.4% of women. In patients with endometriosis, adenomyosis was detected much earlier than others. In addition, these women had found a violation of tubal patency, which was the stronger, the more pronounced there were signs of adenomyosis Symptoms of adenomyosis - characteristic and recognizable . It is well known that of tubal patency depends largely on the probability of pregnancy.

It was also noted that for successful conception reduction transitional area connecting the uterus during embryo implantation should be minimal .  Excessive reduction of transitional areas connecting women with adenomyosis dramatically reduce the likelihood of implantation .  The probability of pregnancy was the most large in cases where the woman is less than five beats per minute .  It should be noted that these findings were made on the results of surveys of women who do IVF .  However, it is likely that the reduction transitional area connecting women with adenomyosis reduce the chance of getting pregnant and those who are trying to conceive naturally .  During the research it was noted that adenomyosis often leads to the fact that cuts are becoming more frequent, become irregular, and disrupted the mechanisms by which sperm get into the womb .

Another cause of infertility in adenomyosis can be anomalous concentration of free radicals in the uterus. An excess of free radicals can cause damage to a fertilized egg, and prevent the normal development of the embryo.

Treatment of infertility in adenomyosis

So far there have been no systematic studies of treatments for infertility associated with adenomyosis Adenomyosis - avoid constant stress Although in the last twenty years, doctors used to do a lot of different techniques - more or less successfully. In general, pregnant with the adenomyosis is possible, although it is possible not all patients.

Of first choice for the treatment of infertility in women with adenomyosis it is usually one or another drug from the group of gonadotropin-releasing hormone. Good results could be obtained when using a drug therapy, and with the combination of drugs and surgery.

Uterine artery embolization is now widely used to treat infertility in adenomyosis .  In one study involved 94 women with adenomyosis, which made the uterine artery embolization .  Six of them wanted to get pregnant, and the five succeeded, one of the subjects after the operation became pregnant twice .  In addition, two pregnancy occurred because of problems with contraception, and one of the women who became pregnant had an abortion .  Of the seven pregnancies (including two one woman), five ended with vaginal delivery, and two - by Caesarean section .  One woman went into premature labor, and the baby had a low birth weight, but it does not have a negative impact on its further development .  To make valid conclusions about how effective is uterine artery embolization for women suffering from adenomyosis, and want to get pregnant need additional, more extensive and qualitative research .

For the treatment of adenomyosis Adenomyosis - treatment should be individualized   It can also be used a resection of the endometrium. One of the latest - and probably safer - varieties of this operation - high-intensity focused ultrasound ablation. This technology uses the external action of ultrasonic energy to using heat to destroy certain areas of tissue in the uterus. Thus the skin remains intact. Earlier this method was used only for the treatment of malignant tumors, but now with the help and treat adenomyosis.

Because the technology is relatively new, there is very little information on its effectiveness in the treatment of infertility Infertility Treatment - What principles are priority . At the moment, it described only one case where a woman suffering from adenomyosis and infertility, failed to conceive after high-intensity focused ultrasound ablation. The woman, whose age is 36 years old, could not get pregnant because of the severe menometrorrhagia - disorders characterized by an abnormally prolonged menstrual bleeding, as well as frequent intermenstrual bleeding. Six weeks after surgery menometrorrhagia symptoms become much less severe, and after some time she became pregnant; pregnancy was normal and resulted in vaginal birth.