Prednisone has many side effects and contraindications, so its use during pregnancy is not desirable. At the same time, and in pregnant women may be indications for use of the drug. In this case, try to prescribe prednisone short course - it causes fewer complications.
Action prednisolone during pregnancy
Prednisone - is a synthetic analogue of glucocorticoid hormones (GCS), which are produced by the adrenal cortex. All corticosteroids have a multilateral impact on the human body. The first action concerns the SCS metabolic processes. So, prednisolone causes increased protein breakdown and the formation of its breakdown products of glucose
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. A large number of glucose stimulates the processes of decomposition and synthesis of (mostly) adipose tissue.
All these processes can not but have an impact on the body of a pregnant woman. Pregnant women need more protein to build tissue growing fetus. Chronic administration of prednisolone amount of protein in the serum is reduced, this results in impaired growth and development of the fetus.
Deposition of increased amounts of fat lead to a significant weight gain, which is further increased by the latent edema prednisolone retards body sodium and water, and outputs the potassium and calcium. Potassium deficiency leads to disturbances from serechno circulatory system, and the lack of calcium - a violation of the formation of bone in a child and tooth decay in the mother.
The negative impact has prednisone and blood vessels, as it stimulates the activity of adrenaline. Adrenaline or stress hormone
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It contributes to spasm of blood vessels and increase blood pressure, which is absolutely not desirable during pregnancy because it can lead to placental insufficiency, to circulatory problems and growth retardation.
Prednisolone also suppresses the immune system, and it is during pregnancy and so is reduced - it creates a threat of bacterial, viral and fungal infections.
Inhibition of cell proliferation (cell division) tissue may also adversely affect the condition of the fetus, so the use of prednisolone is particularly undesirable in the first 12 weeks of pregnancy, when there is the most intense cell division and laid his fetal organs and tissues.
Furthermore, prolonged use of prednisone can rootstock adrenocortical function in women and fetus, which would require later replacement therapy.
When prednisone may be used during pregnancy
Yet, in some situations, prednisolone used in pregnancy. The fact that all these side-effects of the drug appear mainly against its prolonged use at high doses. Short courses also usually do not cause serious violations on the part of the mother's body and fetus.
In some cases, the use of prednisolone during pregnancy is necessary. For example, in severe rheumatoid arthritis or asthma, glomerulonephritis, systemic connective tissue diseases, and so on.
In rheumatoid arthritis, brief courses of prednisolone are more effective and have fewer side effects than the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac. Almost all NSAIDs have teratogenic effects on the fetus, that is causing the anomalies of its development.
In severe asthma, when not helping inhaled corticosteroids form (do not remove an attack of bronchospasm), short-course of prednisolone at an exacerbation of the disease brings significant relief to a pregnant woman.
Finally, there is practically no contraindications to the use of prednisolone in anaphylactic shock, usually occurs in parenteral (injection) administration of drugs that cause allergies. In this case, prednisolone is administered in the form of injections for health. The most dangerous symptom of an anaphylactic shock is a sudden sharp drop in blood pressure, which can lead to cardiac arrest.
Introduction prednisolone stimulates the action of adrenaline, which promotes a spasm of blood vessels and raising blood pressure - it is the action of prednisolone saves patients during anaphylactic shock.
Are prednisone to maintain the pregnancy?
Previously, such a method of treatment of miscarriage
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It used widely enough. But experience has shown that long-term use of prednisone does more harm than good. So today prednisolone
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to this end, it is not widely applied. In some instances, at elevated content in the blood of women of male sex hormones (hyperandrogenism) are assigned to treatment with another SCS - deksometozonom that usually no complications.
Prednisolone is used during pregnancy, but strictly on the testimony.