During pregnancy, often have reasons for receiving Aescusan. First of all, swelling in the legs with varicose veins Varicose veins - the operation is inevitable?   and hemorrhoids that during pregnancy a woman deliver much trouble. Aescusan - a non-toxic herbal medicines, however, every woman should know that during pregnancy it can be treated only by a doctor.

Why during pregnancy disturbed venous circulation

Pregnancy is always promotes disorders of venous circulation, especially if the woman leads a sedentary lifestyle. The growing uterus compresses the veins in this small basin, which leads to stagnation of venous blood in the lower extremities and in the rectal area.

When stagnation of venous blood in the lower limbs develops varicose veins, blood is not completely lifted up the veins and stagnates in the veins. Vienna expand and become tortuous, promotes the formation of blood stagnation of blood in the veins - thrombophlebitis. Legs pregnant women can swell, appear cramps in the calf muscles, it becomes difficult to walk.

The second problem during pregnancy - a stagnation of venous blood in the rectal area and the formation of hemorrhoids. Contribute to this and constipation, which are characteristic for the state of pregnancy due to the suppression of motor activity of the intestine female sex hormone progesterone Progesterone - norm and pathology .

Hemorrhoids can deliver a pregnant woman more trouble than varicose veins. In some women, it goes unnoticed or with minimal symptoms, while others experience severe pain, itching, and are constantly under threat of infringement of the haemorrhoid and the development of acute hemorrhoids.

And since everyone knows that during pregnancy should not take a different "chemistry", many women tend to use for the treatment of venous insufficiency products of plant origin, including Aescusan. But can it be treated eskuzanom Aescusan - help with venous insufficiency   during pregnancy?

How does Aescusan

Active ingredient Aescusan is escin, which is contained in the seeds of the horse chestnut. This substance tones vein walls, it reduces their permeability and reduce inflammation, including swelling, pain and itching.

In addition, estsin a capillary protector - he actively supports the normal state of the smallest blood vessels - capillaries, protects them from the harmful effects, reduces the permeability of the walls and improves blood circulation. The result is improved both venous and arterial blood flow, reduced tendency to form blood clots in the veins.

Such a multifaceted effect on the venous and capillary network Aescusan allowed to apply for any form of venous insufficiency Venous insufficiency - rapidly Youthful disease But primarily for varicose veins and hemorrhoids.

Aescusan contraindicated in case of hypersensitivity to it, and the body of the patient with chronic renal failure.

Available Aescusan only in dosage forms for oral administration - in the form of drops and tablets Aescusan Aescusan 20. Some pharmaceutical companies produce drugs soderzhashih estsin in the form of a gel for topical application. These drugs include, for example, Reparil venen gel and gel Dr. Theiss.

Can I use Aescusan during pregnancy

During pregnancy Aescusan is not recommended due to the fact that there is no reliable data on the safety of this drug for a pregnant woman and the fetus. Manufacturers of the drug (for example, well-known company Schering) believe that their clinical trial data are insufficient for the drug Aescusan 20 (tablets) in pregnant women. Information about the clinical trials of the drug in pregnant women Aescusan as an alcoholic solution is not provided.

Nevertheless, Aescusan drops are sometimes used for treatment of pregnant women with venous insufficiency, but experience with this drug in pregnant women is not sufficiently warranted.

In addition, the use of Aescusan contraindicated in violation of renal function, and in pregnant women, as it is known, on the kidneys is a double burden.

Thus, Aescusan, like any other drug, can be administered to a pregnant woman only physician in the presence of vital evidence. Aescusan can be replaced by other drugs, which include escin, for example, Reparil-gel and venen-gel Dr. Theiss - formulations for external use with escin for pregnant women is not contraindicated.

Galina Romanenko

Exoderil - is an antifungal drug which is available only in dosage forms for external use - as a solution, gel and cream. Exoderil during pregnancy can not be used due to the fact that some of the activities of the active substance can be absorbed into the bloodstream and to the general (systemic) effect on the body.

How does ekzoderil

The structure includes Exoderil active substance naftifine - antifungal agent of the allylamine. Another widely used today allylamine is terbinafine (limizil).

Exoderil highly lipophilic, that is, the tendency to accumulate in fatty tissue. When applied to the skin, it penetrates well into all of its layers, creating in them a concentration sufficient to suppress the vital activity of cells and destruction of the main pathogens of fungal infections Fungal infection: to prevent and defeat . Exoderil penetrates through the skin layers and the average is stored in the lipophilic stratum corneum (outer) layer of the skin, and then excreted by the sebaceous and sweat glands, thereby creating high concentrations in the hair follicles, sweat glands area. The mechanism of action is associated with the suppression of Exoderil synthesis of ergosterol - a substance necessary for the construction of the cell membranes of fungi. This leads to the destruction of fungal cells.

He ekzoderil accumulated in the nail plate. Therapeutic concentrations in nails is achieved during the first few weeks, and stored up to six months after treatment, but in the end (which is to be circumcised) of the nail therapeutic konetsentratsiya saved less long, for no more than two months after the cancellation. The rate of penetration into the tissue of the nail Exoderil exceeds its rate of growth.

With about 6% active active substance can enter the bloodstream and exert a systemic effect, penetrating into many tissues. Ekzoderil displayed for two - three days with urine and feces partially intact, and partially as metabolites (metabolic products).

How does ekzoderil pregnant women

But no one knows, because the test Exoderil Exoderil - treat fungal infections   in pregnant women were not conducted. However, laboratory studies were carried out on animals which have not confirmed the fact of the (including mutagenic or teratogenic) effects Exoderil on the body of the pregnant woman and the fetus. Thus, rats and rabbits were administered an oral dose of the active substance acting ekzoderil naftifine 150 times and more greater than the dose for humans when applied topically.

Nevertheless, naftifine may enter the bloodstream and exert the overall effect on the organism, so its use during pregnancy is not desired. Of course, when used correctly by a physician naftifine negative impact on a woman's body and the fetus is unlikely. Yet such a development can not be completely excluded.

Why ekzoderil poses a risk for pregnant women

It is evident that for most women is no danger in the external application Exoderil not. At the same time for some of the negative effects of women this drug on the fetus is possible.

This is due to the fact that the blood is sucked into the 6% naftifine degraded in the liver and excreted by the kidneys after or intestine. Different women work of these bodies has its own characteristics. So, very often the physiological characteristics of the enzymatic activity of the liver. That liver enzymes contribute to the degradation of a substance in the metabolic products (metabolites). Excretion of the substance and its metabolites through the biliary tract and intestines or through the blood, kidney and urine. All these bodies may have their physiological characteristics that result in these or other substances can accumulate in the body.

For pregnant women, the bodies which operate with increased load, and sometimes show tissue complete unpredictability of the effects of a substance, even such small concentrations in the blood can make a difference. That is why the pharmaceutical companies that manufacture a variety of drugs are always very cautious about the possibility of their appointment to pregnant women.

You can apply ekzoderil pregnant women or not?

This question should be decided by the attending physician. It depends on the type of fungal infection, the general condition of pregnant women and fetal condition. If the use of this drug really needed a pregnant woman, the doctor takes the responsibility of his appointment. Independently apply any Exoderil dosage forms (despite the fact that it is applied only topically) is absolutely contraindicated for pregnant women.

Galina Romanenko