Egilok - a drug that enhances the coronary arteries, lower blood pressure, and restoration of normal heart rhythm. This allows you to assign various actions egilok in many cardiovascular diseases.

The mechanism of action egilok

Egilok (INN - metoprolol) - a drug that belongs to a group of cardioselective (acting selectively on the heart) beta1-adrenergic blockers. Available Hungarian pharmaceutical company Egis in tablets of 25 and 50 mg tablets, and sustained-release (long-term) action called egilok retard 50 and 100 mg.

Various pharmaceutical firms metoprolol is released under the following names: betalok (betalok KRC) vazokardin (vazokardin retard) korvitol (korvitol 50, 100), metogeksal, metokard, metolol, metopress, metoprolol, metoprolol PF, metoprolol Acre, metoprolol-ratiopharm, metoprolol tartrate, serdol, spesikor, emzok. All of these drugs are analogues egilok.

Drugs belonging to the group of beta1-adrenergic blockers, block the transmission of adrenalin adrenaline and substances susceptible to it receptors (nerve endings), located directly in the heart muscle (myocardium). And as adrenaline stimulates heart rate and constricts blood vessels, the drugs that block its action, have the opposite effect.

Egilok causes expansion of the coronary arteries, resulting in myocardial cells receives more nutrients and oxygen. This effect is used in the treatment of coronary heart disease (CHD) - angina and myocardial infarction. Removed stimulating effect of adrenaline on the myocardium, which leads to inhibition of excitability and conduction of nerve excitation, slowing heart rate and recovery heart rate. As a result, reduce the number of heart rate (HR) decreased myocardial oxygen demand.

Lowering blood pressure (BP) is due to the decrease in cardiac output and formation of renin (substances that promote blood pressure), inhibition of the renin-angiotensin system (special system that would increase blood pressure) and central nervous system. Under the influence of egilok restored normal operation particularly sensitive to changes in pressure of the nerve endings (baroreceptors) aortic and they do not usilenivayut their activity in response to a decrease in blood pressure, which when taken regularly for several weeks leads to its steady decline in the rest, with exertion and stress How to beat stress? Create an oasis . Lowering blood pressure occurs in fifteen minutes after tablet egilok, reaches a maximum within two hours and maintained for six hours.

Chronic administration of EGIS reduces cholesterol in the blood and prevents migraine attacks by preventing the expansion of cerebral blood vessels (small blocking beta2-adrenergic receptors located in the internal organs and the peripheral walls of the blood vessels).

Indications and contraindications

Egilok appointed the doctor individually selected dosage. Admission egilok shows:

• with hypertension;
• coronary heart disease (including angina and myocardial infarction);
• in disorders of heart rhythm;
• at elevated thyroid function;
• for the prophylaxis of migraine.

Contraindications reception egilok low blood pressure, including those in cardiogenic shock at the atrio-ventricular block (impaired conduction of nerve impulses from the atria to the ventricles) II and III degree sinoatrial blockade (the transmission of nerve impulses from the pacemaker sinus node to the atria) syndrome sinus (SSS), bradycardia with a heart rate less than 50 beats per minute, severe heart failure, angina Prinzmetal Prinzmetal angina - a rare disease with serious consequences   (unstable form of angina pectoris with prolonged severe attacks), while feeding the baby Breastfeeding - a personal choice   breast, along with some other antihypertensive drugs, with hypersensitivity to the drug.

Precautions egilok appoint diabetes (can cause a sharp decrease in blood sugar), metabolic acidosis, bronchial asthma, chronic obstructive pulmonary disease, obliterating (a violation of the road) peripheral vascular disease, chronic liver and kidney failure, muscle weakness, atrioventricular block I degree of depression Depression - a little more than a bad mood , Psoriasis, pregnancy at the age of 18 and elderly patients.

Egilok side effects associated with its influence on beta2-adrenergic receptors. When taken in recommended doses egilok has little effect on the organs containing the beta2-adrenergic receptors, which are located in the internal organs (pancreas, skeletal muscle, smooth muscle of the peripheral arteries, bronchi, uterus). Adrenaline relaxes the smooth muscles of these organs and systems, so blocking its action may cause them restriction, including bronchospasm. When receiving egilok at high doses (over 100 mg), its side effects are amplified.

Egilok can be used only on prescription.

Galina Romanenko

Egilok - a drug that blocks the action of adrenaline on the heart. Crank called the stress hormone How to beat stress? Create an oasis He leads the body on full alert during the impending danger, under its influence often heart begins to decline, and the blood vessels to constrict, which increases blood pressure.

Egilok refers to beta1-blockers, which act selectively only on the heart. Receptors - are nerve endings, which are susceptible to a particular neurotransmitter - a substance which is transmitted via nerve impulses. Beta1-adrenergic receptors located in the heart. Beta2-adrenoreceptors located in other internal organs. It is important that egilok selectively acts precisely on beta1-adrenergic receptors without affecting the receptors located in other organs. Nevertheless, completely deprived of its effect on Board 2-adrenoreceptors and was unable to act on other organs and systems are also manifested as side effects, but to a small extent.

Action egilok heart

Since egilok removes the direct effect of adrenaline and other substances adrenalin on the heart, the first thing it leads to the expansion of the arteries feeding the heart muscle (coronary arteries). In the heart muscle (myocardium) begins to flow more oxygen and nutrients, and it begins to work more productively. Simultaneously egilok inhibits excitability and conduction of nerve impulses on the cardiac conduction system. All this leads to the fact that the heart rhythm is restored, the heart begins to contract and less likely for it to work requires less oxygen.

This action egilok is widely used in the treatment of coronary artery disease - angina Angina - the consequences of the activity   and rest and myocardial infarction. Under the influence of egilok angina attacks become less frequent, and sometimes even disappear. Often, like angina at rest Angina rest - invisible enemy   - Attacks of pain in the heart, which may arise out of the physical or mental stress. Egilok is an excellent prevention of myocardial infarction, and it is used to treat the disease.

It will egilok and other heart diseases, which are accompanied by cardiac arrhythmias.

Action egilok blood vessels

Since under the influence egilok reduced blood volume which is ejected with each heart contraction in the circulatory system, this leads to a decrease in pressure in the circulatory system. In addition, under the influence of egilok reduced synthesis of renin - substances that improve blood pressure (BP). Inhibited the activity of the renin-angiotensin system, maintain a high tone of blood vessels. As a result, blood pressure drops within fifteen minutes after taking egilok and its effect lasts for six hours. In order to pressure decreased steadily egilok need to take at least two weeks in a row.

Egilok recommended to take with hypertension, especially if high blood pressure is combined with angina. Assign it at elevated thyroid function - large amounts of thyroid hormones in the blood contributes to the rise in blood pressure, and various changes in the cardiovascular system.

This is a drug for continuous use, its dosage for the patient chooses a doctor.

Who should not take

Egilok not take the low blood pressure, it is particularly dangerous in the case where such a drastic reduction in blood pressure occurred on the background of myocardial infarction - it says cardiogenic shock.

Contraindications egilok and expressed violations of excitability and conductivity - heart block, because it slows down the nerve impulses on the cardiac conduction system. Blockade first degree it is administered, but with caution.

If the patient has bradycardia, that is the number of heartbeats per minute less than fifty, egilok also contraindicated. You can not assign egilok and if the heart is unable to cope with its load to ensure that all organs and tissues of arterial blood, that is, if it sharply reduced contractility. This condition is called congestive heart failure, as well as the egilok reduces blood volume, which throws the heart with each contraction, when it received heart failure will increase.

Do not use egilok during feeding baby Breastfeeding - a personal choice   breast and are hypersensitive to the drug. With care, after weighing the potential benefits to the mother and the alleged harm to the fetus, egilok administered during pregnancy. Also, with caution it is prescribed for liver and kidney failure.

Galina Romanenko