Roaccutane - a synthetic analogue of vitamin A, which is known, large doses may be toxic to the organism. A feature of Roaccutane is precisely his appointment in large doses, so the treatment of acne the doctor has to choose such a dose that can effectively suppress the development of acne, without causing irreversible side effects.
How are acne
Acne (acne) are formed due to increased shedding of the epithelial cells of the hair roots and sebaceous glands (sebocytes). Formed inside sebocytes of the sebaceous glands and vary slowly (mature), moving towards the surface of the duct. Inside sebocytes accumulate fat.
After contact with the surface of the sebaceous gland sebocytes burst, causing plugging-fat and cell debris of the sebaceous glands and sebaceous plugs formation (comedones). Comedones are covered with dust and dirt and have the form of black dots. The corked sebaceous glands begin to multiply rapidly and infectious agents begins purulent inflammation.
How does roakkutan
Roaccutane - an effective drug that is manufactured by the pharmaceutical company F. Hoffmann Swiss-La Roche Ltd in capsules for oral administration of 10 and 20 mg.
When administered isotretinoin is better absorbed if it is taken during or immediately after a meal. Once in the blood, and then the skin roakkutan inhibits the proliferation (proliferation) sebocytes and restores the correct maturation process, whereby the amount of sebum and its chemical composition are normalized. And how sebum is a breeding ground for the growth of pathogens festering infection, taking Roaccutane inhibits bacteria and the development of the inflammatory process.
This leads to a large number of side effects of the drug, and therefore it may appoint a doctor.
To prescribe isotretinoin and when it is contraindicated
Roaccutane is prescribed for the treatment of severe acne
Acne: facial trouble
When creating the threat of deep skin lesions followed by the formation of scars. Assign roakkutan also when acne can not be any other type of treatment.
However, this takes into account contraindications for the appointment of the drug. It should not be prescribed if you are hypersensitive to the components of the drug by the body of the patient, high content of Vitamin A or lipids in the blood, abnormal liver function, while taking drugs of the tetracycline group, while feeding the baby
Breastfeeding - a personal choice
chest and under the age of 12 years. Especially dangerous is Roaccutane for pregnant women, as almost always cause abnormal development of the fetus. You can not take it and the planning period of pregnancy - at least one month prior to conception.
Precautions isotretinoin is prescribed for depression, diabetes, obesity, lipid metabolism disorders, chronic alcoholism.
Manufacturers say that if you prescribe Roaccutane in recommended doses, and taking into account the contraindications, side effects can be minimized. However, they can be very significant and not all of them tested after treatment. For example, the central nervous system may cause headaches, depression
Depression - a little more than a bad mood
, Behavioral changes, seizures, increased intracranial pressure. At the same time there may be visual and hearing impairment.
May be affected and the digestive organs. Chronic administration of Roaccutane in large doses may cause nausea, diarrhea, colitis, intestinal bleeding, disorders of the pancreas
Diabetes and pancreas - the things you need to know
and liver, sometimes take a very severe course (acute pancreatitis and acute hepatitis). Most often, these violations are of a temporary nature, but sometimes remain after withdrawal of the drug.
In some cases, side effects are caused by the blood: decreased erythrocyte count, hemoglobin, white blood cells (including neutrophils, that play a significant role in immunity) and platelets. It may be accelerated ESR. Patients with asthma may be more frequent bouts of bronchospasm. In many patients, pain in muscles and joints.
There are also side effects Skin rash, itching, redness and irritation of the skin, sweating, various pus and exchange-dystrophic changes in the nails and fingertips. Hair thinning and may fall out, there is an increased body hair and liver spots on the skin. There are different kinds of allergies are allergic to the light to severe allergic reactions such as Stevens-Johnson.
Signs of hypervitaminosis A
Chronic administration of high doses of Roaccutane showing signs of hypervitaminosis A: dry skin and mucous membranes (such as cracks on the lips, nosebleeds, hoarseness, irritation of the conjunctiva, intolerance to contact lenses, and so on).
Roaccutane - a drug whose mechanism of action is not yet sufficiently understood. He has a lot of side effects and to minimize them only by a specialist.