Roaccutane - a synthetic analogue of vitamin A, which is known, large doses may be toxic to the organism. A feature of Roaccutane is precisely his appointment in large doses, so the treatment of acne the doctor has to choose such a dose that can effectively suppress the development of acne, without causing irreversible side effects.

How are acne

Acne (acne) are formed due to increased shedding of the epithelial cells of the hair roots and sebaceous glands (sebocytes). Formed inside sebocytes of the sebaceous glands and vary slowly (mature), moving towards the surface of the duct. Inside sebocytes accumulate fat.

After contact with the surface of the sebaceous gland sebocytes burst, causing plugging-fat and cell debris of the sebaceous glands and sebaceous plugs formation (comedones). Comedones are covered with dust and dirt and have the form of black dots. The corked sebaceous glands begin to multiply rapidly and infectious agents begins purulent inflammation.

How does roakkutan

Roaccutane - an effective drug that is manufactured by the pharmaceutical company F. Hoffmann Swiss-La Roche Ltd in capsules for oral administration of 10 and 20 mg.

When administered isotretinoin is better absorbed if it is taken during or immediately after a meal. Once in the blood, and then the skin roakkutan inhibits the proliferation (proliferation) sebocytes and restores the correct maturation process, whereby the amount of sebum and its chemical composition are normalized. And how sebum is a breeding ground for the growth of pathogens festering infection, taking Roaccutane inhibits bacteria and the development of the inflammatory process.

This leads to a large number of side effects of the drug, and therefore it may appoint a doctor.

To prescribe isotretinoin and when it is contraindicated

Roaccutane is prescribed for the treatment of severe acne Acne: facial trouble When creating the threat of deep skin lesions followed by the formation of scars. Assign roakkutan also when acne can not be any other type of treatment.

However, this takes into account contraindications for the appointment of the drug. It should not be prescribed if you are hypersensitive to the components of the drug by the body of the patient, high content of Vitamin A or lipids in the blood, abnormal liver function, while taking drugs of the tetracycline group, while feeding the baby Breastfeeding - a personal choice   chest and under the age of 12 years. Especially dangerous is Roaccutane for pregnant women, as almost always cause abnormal development of the fetus. You can not take it and the planning period of pregnancy - at least one month prior to conception.

Precautions isotretinoin is prescribed for depression, diabetes, obesity, lipid metabolism disorders, chronic alcoholism.

Side effects

Manufacturers say that if you prescribe Roaccutane in recommended doses, and taking into account the contraindications, side effects can be minimized. However, they can be very significant and not all of them tested after treatment. For example, the central nervous system may cause headaches, depression Depression - a little more than a bad mood , Behavioral changes, seizures, increased intracranial pressure. At the same time there may be visual and hearing impairment.

May be affected and the digestive organs. Chronic administration of Roaccutane in large doses may cause nausea, diarrhea, colitis, intestinal bleeding, disorders of the pancreas Diabetes and pancreas - the things you need to know   and liver, sometimes take a very severe course (acute pancreatitis and acute hepatitis). Most often, these violations are of a temporary nature, but sometimes remain after withdrawal of the drug.

In some cases, side effects are caused by the blood: decreased erythrocyte count, hemoglobin, white blood cells (including neutrophils, that play a significant role in immunity) and platelets. It may be accelerated ESR. Patients with asthma may be more frequent bouts of bronchospasm. In many patients, pain in muscles and joints.

There are also side effects Skin rash, itching, redness and irritation of the skin, sweating, various pus and exchange-dystrophic changes in the nails and fingertips. Hair thinning and may fall out, there is an increased body hair and liver spots on the skin. There are different kinds of allergies are allergic to the light to severe allergic reactions such as Stevens-Johnson.

Signs of hypervitaminosis A

Chronic administration of high doses of Roaccutane showing signs of hypervitaminosis A: dry skin and mucous membranes (such as cracks on the lips, nosebleeds, hoarseness, irritation of the conjunctiva, intolerance to contact lenses, and so on).

Roaccutane - a drug whose mechanism of action is not yet sufficiently understood. He has a lot of side effects and to minimize them only by a specialist.

Galina Romanenko

The structure of retinoic ointment includes the same active substance as in roakkutan Roaccutane - a drug for the treatment of severe acne But she issued another pharmaceutical company - Retinoids (Russia), while roakkutan releases Swiss pharmaceutical company F. Hoffmann-La Roche Ltd only in capsules for oral administration.

How does retinoic ointment

Active ingredient retinoic ointment - isotretinoin is biologically active synthetic analogue of vitamin A (retinoid), belonging to the group of stimulants tissue regeneration. Auxiliaries are BHT, butylhydroxyanisole, emulsifying wax, petrolatum, gliitserin, 95% ethanol, purified water.

The mechanism of action of retinoic ointment is based on the fact that after application to the skin, it delays the multiplication of the final maturation of the epithelial cells of the sebaceous duct (sebocytes) that produce sebum - it reduces salovydeleniya.

Simultaneously retinoic ointment has a normalizing effect on the chemical composition of sebum, facilitates the process of elimination and helps dissolve dead cells desquamated able to score sebaceous glands (keratolytic action).

All this contributes to the fact that the ducts of the sebaceous glands are not clogged and do not create the conditions for enhanced growth of bacteria and maturing eels (indirect anti-inflammatory and antibacterial action). Like all retinoids, isotretinoin activates the regenerative processes in the skin (regenerative effect).

Under what conditions apply

The mechanism of action of retinoic ointment Retinoic ointment - help with acne and wrinkles   It allows us to use it in the treatment of acne Acne treatment: how to get rid of blackheads . The basis of this disease is a violation of the sebaceous glands, which produce large amounts of sebum to the chemical composition. Moreover, when acne increases exfoliation of cells of the sebaceous glands, which are mixed with sebum increased viscosity obstruct the ducts of the sebaceous glands. Inside the closed sebaceous glands begin to actively proliferate bacteria that cause inflammation - develop acne or acne. Retinoic ointment inhibits all stages of the formation of acne - which is why its use is effective in this disease. In severe forms of acne, when there is a threat to the formation of scars on the skin, retinoic ointment helps to restore the skin and slows down the process of scarring.

The positive effect of retinoic ointment has also at seborrheic dermatitis - an inflammatory disease of the skin caused by a fungal infection. Seborrheic dermatitis is more common in men, particularly in the area of ​​facial hair, as well as in the area of ​​the scalp, a place on the skin where there are many sebaceous glands. Amazing and smooth skin around the nose, forehead, chest and back. Disease is manifested in the form of skin irritation. The fungi that cause seborrheic dermatitis, feed on sebum, so reducing sebum helps to suppress propagation of infectious agents and the gradual development of remission.

Manufacturers recommend and assign retinoic ointment rosacea (pink acne) - a disease characterized by non-infectious inflammation of the skin associated with vascular disorders. Retinoids protect and regenerate skin cells, and have a positive effect on the capillaries of the skin. But such a complex is not fully studied the disease as rosacea, requires an integrated system of treatment under the supervision of a physician.

Anti-inflammatory effect will retinoic ointment and perioral dermatitis - inflammation of unknown origin, which develops in the skin around the mouth mostly in young women.

In all these diseases retinoic ointment thinly applied on clean skin twice a day (morning and evening). The course of treatment lasts from one to one and a half months. On prescription treatment may be extended or repeated.

Contraindications and side effects

Retinoic ointment should not be used when hypersensitivity to its components, pregnancy (including in its planning), feeding baby Breastfeeding - a personal choice   breast, kidney function and liver, chronic pancreatitis, severe cardiovascular diseases, hypervitaminosis A, benign and malignant tumors of the skin.

When using retinoic ointment may experience the following side effects of skin - skin redness, dryness, peeling, various allergic skin rash, itching, swelling of the skin allergies to light (photosensitivity); In all these cases overturned ointment and anti-inflammatory treatment is carried out; allergy treatment is not resumed; often such side effects occur within a week after the start of treatment.

Retinoic ointment (unlike Roaccutane) are sold in pharmacies without a prescription, but to use it all the better for its intended purpose and under the supervision of a physician.

Galina Romanenko