Clotrimazole - side effects in this antifungal drug insignificant since it is performed only in the formulations for topical and local application. Total (systemic) effect of clotrimazole is very small, so the contraindications for the use of clotrimazole is very small.
Clotrimazole - medical effects
The therapeutic effect of clotrimazole is related to its antifungal, antibacterial and antiprotozoal properties. Therefore, various dosage forms of the drug used for the treatment of fungal, bacterial, fungal, protozoal and fungal infections of the skin and mucous membranes.
The mechanism of action of this drug is associated with suppression of the synthesis of biologically active substances required for the construction of the membranes of fungi. The disadvantage of these substances leads to the suppression of life activity (fungistatic effect at low dose of the drug) or to the destruction (fungicidal effect with increasing dose) fungal cells.
Sensitivity to clotrimazole show most fungi that cause infections of the skin and mucous membranes of humans. It dermatophytes (fungi causing microsporia
Microsporia - threatening fungal infection
, Trichophytosis and athlete), yeast fungi of the genus Candida, agents of tinea versicolor, erythrasma and so on. Because bacterial pathogens sensitivity to clotrimazole show staphylococci, streptococci, Gardnerella and some other bacteria. Sensitive to him and Trichomonas
Trichomonas - leads to infertility
Clotrimazole is used only for external and topical applications, it comes in the form of vaginal tablets, creams, ointments, gel, lotion, as well as a solution for topical use the mouthrinse.
This is contraindicated use of clotrimazole
Due to the fact that clotrimazole enters the blood in small amounts, contraindications for its use is very small. First of all, the increased sensitivity of the patient to the drug - clotrimazole applied in this case is impossible. Another contraindication is the first trimester of pregnancy. During this period, there is a bookmark of organs and tissues of the fetus, so even a minor hit in the blood of clotrimazole could affect the status of the child - clotrimazole can cross the placental barrier and get to the fetus.
With caution and only by a physician is recommended clotrimazole in other periods of pregnancy. The same caution is recommended clotrimazole during feeding baby
Breastfeeding - a personal choice
feeding, as it can be released from human milk (on the skin of the breast can not be applied clotrimazole). Caution should be observed also in the appointment of clotrimazole in patients with impaired liver function.
Other dosage forms clotrimazole may produce different side effects. It is known that formulations for topical use (cream, ointment, gel) is very little absorbed into the blood, whereas the application of local dosage forms (vaginal tablets) in the blood gets about 3% of active principle.
Most often arise in the application of clotrimazole local irritation reactions. When applied to the skin may cause itching, burning, sensory disturbances (goose bumps). On the skin, redness and swelling. On the mucous membranes and may cause irritation. When using vaginal tablets to the symptoms of thrush can join additional burning and itching caused by clotrimazole. Whether to continue treatment in this case, the doctor decides.
Allergic reactions can occur in the application of any drug, including clotrimazole. On the skin, it can manifest as hives, spread to surrounding healthy skin lesion, as well as a contact dermatitis allergichekogo, the first manifestations of which are developed not earlier than 10 days after the start of treatment. Contact allergic dermatitis manifested as redness and swelling of the tissue sections, which are regularly applied clotrimazole. Then, at the inflamed surface bubbles appear with clear content which burst to form crusts and erosions.
Mucosal allergy manifests itself in the form of redness, swelling
Prevention and treatment of edema - it is important to understand the root cause
, The appearance of hives on the adjacent skin.
When a suspected allergy should discontinue the use of clotrimazole and seek medical advice.
Any dosage form of clotrimazole can cause minor side effects such as local irritation and allergic reactions. When a side effect is best to consult a doctor: it determines that it - local irritation or allergic reaction.