For the treatment of hormone-dependent tumors today used drugs - analogs of hormones of the hypothalamus - part of the brain responsible for the operation of the entire neuroendocrine system. This group of drugs include and buserelin. Instructions for use of the drug is designed for physicians, however, patients often want to understand how it works or that drug.
The mechanism of action of buserelin
Buserelin (active substance - buserelin acetate) - is an anticancer drug, an analog of gonadotropin-releasing hormone (GnRH). Buserelin produced by domestic pharmaceutical companies Pharm-Sintez, Deco and Diamed as a solution for intramuscular injection (depot buserelin) long-acting (one injection lasts for a month) and a nozalnogo spray. I sat down recently issued another dosage form of the drug - buserelin-Long, which in its composition does not differ from buselerina depot.
In order to understand how the buserelin, you need to submit, how the regulation of the secretion of sex hormones neurohormonal system. Neurohormonal system of regulation of the reproductive system includes the hypothalamus - pituitary gland (the main endocrine glands, which regulate the action of other glands), and gonads (ovaries in women and testes in men). Using their hypothalamus hormones can stimulate or, conversely, to reduce the formation of pituitary gonadotropins (TG), which in turn stimulates secretion of sex hormones. There is feedback: if generated a lot of sex hormones, it inhibits the secretion of TG.
Buserelin is a synthetic analogue of gonadotropin-releasing hormone from the hypothalamus, which stimulates the secretion of TG. TG secretion stimulation causes a transient increase in the secretion of hormones. Then (about two weeks) triggered feedback: a large number of sex hormones causes a persistent inhibition of secretion of TG and without hormones do not stand out. That is, there comes a medical castration. Lack of sex hormones strongly inhibits the growth of hormone-dependent tumors, as well as areas of endometriosis and uterine hyperplasia (this process is also stimulated by sex hormones).
After treatment the functioning of the reproductive system is gradually recovering. GnRH analogues are today considered the most effective drugs for the treatment of hormone-dependent diseases of the reproductive system.
Indications and contraindications
Buserelin administered with hormone-dependent tumors (prostatic cancer, breast cancer, uterine cancer), endometrial hyperplasia
Hyperplasia endometrial cancer - requires timely detection and treatment
uterus, endometriosis. In addition, buserelin used during in vitro fertilization (IVF) to suppress its own hormonal system of the woman (then creates an artificial, controlled reproductive system - this allows timely implanted woman in vitro fertilized egg).
Do not use this buserelina during pregnancy, infant feeding
Breastfeeding - a personal choice
breasts and in case of hypersensitivity to the drug the patient.
When applying buserelin may cause several side effects. This can be an allergic reaction (often they occur in the form of urticaria, sometimes - in the form of angioedema). On the part of the central nervous system can occur frequent mood swings down to depression
Depression - a little more than a bad mood
, Drowsiness or insomnia, headaches. Since completely inhibited secretion of estrogen, there is a risk of osteoporosis - brittle bones due to insufficient content of calcium. Sometimes noyavlyayutsya nausea, rvrta, diarrhea, abdominal pain
Abdominal pain: Types and Symptoms
. There have been isolated cases of pulmonary embolism.
The treatment buserelina women may suffer from headaches, sweating, dryness of mucous membranes of genitals, abdominal pain, disorders of sexual desire, low mood. In rare cases, early treatment can occur menstrualnopodobnye bleeding.
The men on the background of buserelin treatment at the beginning of treatment may disturb the strengthening of the main symptoms of the disease, pain in the bones, which is associated with short-term increase in the content of male sex hormones in the blood. During treatment, it is also possible occurrence of flares and the upper part of the body, sweating, sexual dysfunction, urinary retention, swelling of the face, lower limbs, weakness in the legs.
Buserelin - a modern, effective drug for the treatment of hormone-dependent tumors.