For the treatment of hormone-dependent tumors today used drugs - analogs of hormones of the hypothalamus - part of the brain responsible for the operation of the entire neuroendocrine system. This group of drugs include and buserelin. Instructions for use of the drug is designed for physicians, however, patients often want to understand how it works or that drug.

The mechanism of action of buserelin

Buserelin (active substance - buserelin acetate) - is an anticancer drug, an analog of gonadotropin-releasing hormone (GnRH). Buserelin produced by domestic pharmaceutical companies Pharm-Sintez, Deco and Diamed as a solution for intramuscular injection (depot buserelin) long-acting (one injection lasts for a month) and a nozalnogo spray. I sat down recently issued another dosage form of the drug - buserelin-Long, which in its composition does not differ from buselerina depot.

In order to understand how the buserelin, you need to submit, how the regulation of the secretion of sex hormones neurohormonal system. Neurohormonal system of regulation of the reproductive system includes the hypothalamus - pituitary gland (the main endocrine glands, which regulate the action of other glands), and gonads (ovaries in women and testes in men). Using their hypothalamus hormones can stimulate or, conversely, to reduce the formation of pituitary gonadotropins (TG), which in turn stimulates secretion of sex hormones. There is feedback: if generated a lot of sex hormones, it inhibits the secretion of TG.

Buserelin is a synthetic analogue of gonadotropin-releasing hormone from the hypothalamus, which stimulates the secretion of TG. TG secretion stimulation causes a transient increase in the secretion of hormones. Then (about two weeks) triggered feedback: a large number of sex hormones causes a persistent inhibition of secretion of TG and without hormones do not stand out. That is, there comes a medical castration. Lack of sex hormones strongly inhibits the growth of hormone-dependent tumors, as well as areas of endometriosis and uterine hyperplasia (this process is also stimulated by sex hormones).

After treatment the functioning of the reproductive system is gradually recovering. GnRH analogues are today considered the most effective drugs for the treatment of hormone-dependent diseases of the reproductive system.

Indications and contraindications

Buserelin administered with hormone-dependent tumors (prostatic cancer, breast cancer, uterine cancer), endometrial hyperplasia Hyperplasia endometrial cancer - requires timely detection and treatment   uterus, endometriosis. In addition, buserelin used during in vitro fertilization (IVF) to suppress its own hormonal system of the woman (then creates an artificial, controlled reproductive system - this allows timely implanted woman in vitro fertilized egg).

Do not use this buserelina during pregnancy, infant feeding Breastfeeding - a personal choice   breasts and in case of hypersensitivity to the drug the patient.

Side effects

When applying buserelin may cause several side effects. This can be an allergic reaction (often they occur in the form of urticaria, sometimes - in the form of angioedema). On the part of the central nervous system can occur frequent mood swings down to depression Depression - a little more than a bad mood , Drowsiness or insomnia, headaches. Since completely inhibited secretion of estrogen, there is a risk of osteoporosis - brittle bones due to insufficient content of calcium. Sometimes noyavlyayutsya nausea, rvrta, diarrhea, abdominal pain Abdominal pain: Types and Symptoms . There have been isolated cases of pulmonary embolism.

The treatment buserelina women may suffer from headaches, sweating, dryness of mucous membranes of genitals, abdominal pain, disorders of sexual desire, low mood. In rare cases, early treatment can occur menstrualnopodobnye bleeding.

The men on the background of buserelin treatment at the beginning of treatment may disturb the strengthening of the main symptoms of the disease, pain in the bones, which is associated with short-term increase in the content of male sex hormones in the blood. During treatment, it is also possible occurrence of flares and the upper part of the body, sweating, sexual dysfunction, urinary retention, swelling of the face, lower limbs, weakness in the legs.

Buserelin - a modern, effective drug for the treatment of hormone-dependent tumors.

Galina Romanenko

Bifidumbakterin a dosage form used in the form of suppositories for treatment of gynecological disorders and for treating diseases of the final part of the intestine - sigmoid colon and rectum. It inhibits the development of opportunistic and pathogenic microflora in these organs, which promotes healing.

Bifidumbakterin as suppositories - it acts

Bifidumbakterin produced in the form of suppositories that can be used vaginally and rectally. Each suppository contains a dose of one million or 50 cfu bifidobacteria. With the introduction of the candles in the vagina or rectum microcolonies of bifidobacteria colonize the wall of the hollow body, and gradually begin to multiply. When the content of bifidobacteria in the body to reach therapeutic concentrations (and it will happen no earlier than on the fifth day), the patient will feel improvement.

When introduced into the vagina bifidumbakterin suppresses growth of conditionally pathogenic and pathogenic microflora, which significantly increased in volume in various infectious and inflammatory processes in this area. In addition, under its influence it restored normal acidity of the body, which affects the livelihoods of conditionally pathogenic microflora and helps restore the normal vaginal purity.

In addition, the introduction of bifidumbacterin rectum contributes to the normalization of the chair: are constipation, which are the main cause of hemorrhoids.

Candles bifidumbakterin in gynecological practice

In gynecological practice bifidumbakterin topically applied in infectious and inflammatory processes in the area of ​​the vagina and cervix (cervicitis and obesity). Bifidobacterium suppress reproduction of pathogenic and conditionally pathogenic microflora (pathogens infectious process is usually more than one), and thereby help to reduce inflammation. After a full course of treatment in the vagina restored normal acidity and the body begins to rid itself of the infectious agents (self-cleaning process of the vagina). Bifidumbacterin usually prescribed as a rehabilitation treatment after a course of antibiotic therapy.

The fact that after menopause in women is reduced secretion of female hormones estrogen, which support the normal (acidic) reacting the vagina. Therefore, in old age is usually formed in the vagina alkaline reaction favorable for the development of opportunistic and pathogenic microorganisms. Therefore, obesity in old age bifidumbakterin sometimes prescribed even without antibiotic treatment.

Independently candles bifidumbakterin prescribed for vaginal dysbacteriosis Dysbacteriosis vagina - how to fight?   - Bacterial vaginosis Bacterial vaginosis - sex is not recommended The main reason is most often gardnerelly related to the pathogenic microflora. Bifidumbacterin can perfectly sanitize the vagina in this case, as opposed to actively gardnerella. Treatment of bacterial vaginosis usually consists of several courses bifidumbacterin.

Apply bifidumbakterin and prevention of septic complications before gynecological surgery, manipulation and delivery. Thus it suppressed a possible source of infection, where the weakening of the body during surgery or childbirth will breed infectious agents that cause severe infection.

Candles bifidumbakterin in gastroenterlogicheskoy and proctologic practice

Candles bifidumbakterin used for the treatment of chronic colitis. In this case, the appointment of candles combined with the appointment bifidumbacterin inside. This helps to suppress reproduction of pathogenic and opportunistic pathogenic microorganisms, restore the health of the intestinal wall and normalization of stool.

If the patient has any diseases of the rectum or anus, there is a risk of infection of the inflamed soft tissue infectious agents, who always live in the intestines. Therefore, hemorrhoids Hemorrhoids - a shameful disease , Chronic proctitis, sigmoid, anal fissure is always held sanitation (improvement of the intestine). This leads to the restoration of a chair, no less important, such as hemorrhoids and anal fissures.

Side effects in the form of candles bifidumbacterin and contraindications

Side effects of this drug only known allergic reactions. Contraindicated bifidumbakterin candles at their individual intolerance of the body of the patient and in children (up to three years).

Galina Romanenko