Orgametril - a synthetic analogue of the natural hormone progesterone the female sex. Since endometriosis in the body produces a lot of estrogen and progesterone little appoint orgametril, which inhibits the synthesis of estrogen and helps to normalize hormonal levels.

What causes endometriosis

The main cause of endometriosis is a hormonal background, in which the body produces a lot of female sex hormones of the first half of the menstrual cycle (estrogen), which contribute to the widening (proliferation) of the mucous membrane of the uterus - the endometrium. Normally, in the second half of the menstrual cycle to replace the estrogen, progesterone comes Progesterone - norm and pathology Which inhibits the proliferation of the endometrium and in the process takes the stage secretion.

When violations of hormonal progesterone little, so long endometrium grows under the influence of estrogen, and when they become a little rejected, accompanied by prolonged heavy bleeding. Rejects endometrium may enter the muscle layer of the uterus and other organs and tissues and form there endometriosis, which usually tend to increase during the cyclic change.

How does endometriosis orgametril

Orgametril (active substance - lynestrenol) is a synthetic analogue of progesterone, which is available in tablets for oral administration, the pharmaceutical company Organon (the Netherlands). Each tablet contains 5 mg orgametrila active principle.

It inhibits the proliferation of the endometrium, causing it to secrete - allocate secret that prepares the uterine wall for the introduction of a fertilized egg. This prevents excessive endometrial growth, and therefore the subsequent strong bleeding.

Receiving additional progesterone leads to suppression of estrogen formation, that is to normalize the menstrual cycle. This helps to suppress the dissemination of endometriosis.

In what cases and how endometriosis appointed orgametril

Orgametril assigned when not heavy and not too common forms of endometriosis. Inhibition of estrogen synthesis and proliferation of the endometrium results in such a case good results - Prevention of growth of endometriosis and sometimes to their regression.

However, in severe forms of endometriosis, this drug is not suitable - in such cases today administered hormones completely suppress ovarian function, thereby terminate cyclic changes in the uterus.

Orgametril take only prescribed by a doctor after survey. The usual course of the drug - one tablet a day at the same time from 14 th to 25 th day of the menstrual cycle The days of the menstrual cycle: Four phases . If endometriosis is accompanied by strong menstrual bleeding, orgametril administered two tablets once a day daily for 10 days.

What side effects may occur during treatment

Orgametril may cause some side effects: uterine bleeding or spotting in the middle of the menstrual cycle (after a while it goes), libido disorders, nausea, abdominal pain Abdominal pain: Types and Symptoms Increase in body weight.

Less common side effects such as headache, dizziness, irritability or depression, sweating, acne, hair growth on male type, the appearance of the face of brown age spots, itchy rash on the skin, icteric staining of the skin and sclera, cessation of menstruation, pain breast area, swelling, older women may cause thirst and frequent urination.

Contraindications for use

Orgametril has a lot of contraindications:

• individual intolerance of components;
• pregnancy and lactation;
• severe liver disease;
• uterine bleeding of unknown nature;
• diseases that are exacerbated during pregnancy or when taking hormonal medications (cold sore, jaundice, skin rash, hearing, etc.);
• the tendency to thrombosis;
• severe mental illness Mental illness - ashamed to ask for help? Which are accompanied with depression;
• diabetes;
• congenital disorders of lipid metabolism.

Precautions orgametril prescribed for high blood pressure.

Orgametril copes well with some forms of endometriosis, but it can be taken only as directed and supervised by a doctor. Endometriosis generally can not be treated independently.

Galina Romanenko

Endometrial or uterine inner layer is a fabric that is highly sensitive to hormonal influences. In the case of hormonal imbalance at various levels of a complex regulatory system developing endometrial pathology. Detection of pathological changes was made possible thanks to the introduction into practice of endoscopic methods of diagnostics and ultrasound.

Specially developed changes in the endometrium

In the uterus due to hormonal imbalance there is excessive growth of the mucous membrane that has been called hyperplasia. This pathological condition may be manifested by a local change of the mucous, then it is considered to be endometrial polyps Endometrial polyps: the result of hormonal disruption . The question of what is the pathology of the endometrium should be read in conjunction with specialists from related professions (doctors pathologists, histology). Confirm the presence of pathological changes in nature can only be conducted on the basis of histological examination.

Quite often combined with endometrial pathology of diseases of the reproductive system:

• endometriosis
• hysteromyoma
• ovarian tumors
• benign changes in the mammary gland (mastopathy)
• neuroendocrine syndrome that developed after birth

The patient should be comprehensively examined in order to identify these comorbidities, as it affects the effectiveness of medical interventions. There are cases of isolated disease of the mucous of the uterus.

This pathology should be considered as an expression of neuroendocrine disorders at the level of relations between the central parts of the brain and the target organs, the uterus and ovaries.

Diagnostic capabilities at the present level

To confirm or exclude the presence of changes in the endometrium can be based on visual inspection of the cavity. This method gives the opportunity to study hysteroscopy. If you do not spend hysteroscopy, then using this method of routine examinations as diagnostic curettage Scraping - heavy and unsafe procedure , You can not totally remove any mucous. This can lead to delayed diagnosis of malignant processes, inefficiencies conservative hormonal therapy.

In some cases, women who have entered a period of natural, physiological changes in the body, developing organic processes in the uterus and ovaries. The method of choice for the survey should be a visual examination of the uterus using a hysteroscope.

Postmenopausal women are at risk of developing endometrial pathology of malignant nature. Atypical processes endometrium detected in 100% of cases during hysteroscopy, wherein the length is detected, the localization of the pathological process. This level of diagnosis improves the efficiency of the treatment, as it gives a complete picture of the processes that occur in the uterus. Ultrasonography using two sensors (abdominal and transvaginal probe) should be included in a comprehensive survey. In postmenopausal women in the ovaries can be detected small formation fluid, always in the first place during the ultrasound scanning should be to prevent the true adnexal mass.

Selecting the treatment regimen

At the same time diagnostic and therapeutic procedures is a separate diagnostic curettage, during which the doctor is able to obtain material for histology and changes in the mucous remove the uterus. It is recommended that this manipulation under control of the hysteroscope. The result of histological examination is the basis for the choice of treatment strategy.

Treatment of endometrial pathology involves holding conservative measures (the appointment of hormonal drugs or physiotherapy), and surgery. The main stage is a hormone therapy aimed at restoring hormonal balance in the body. The drug is prescribed not only on the existing pathology of the uterus, as well as age, comorbidities, and other factors. The spectrum of hormonal drugs is varied, progestins are used, a combination of drugs (estrogens and progestins), androgens.

Conducting surgery purports to reduce the incidence of tumors. In terms of oncological vigilance must be selected active tactics in women who are in the period of pre- and postmenopausal Postmenopause - is it possible to control it? . In this age of endometrial pathology can become a substrate for the development of malignant disease, so the timing of surgical intervention can be attributed to prevention of endometrial cancer and other neoplasms.

Conservative treatment is acceptable in patients with endometrial pathology that are young and wish to preserve reproductive function. In this case, appointed by a long course of hormonal preparations to conduct a dynamic survey of the uterus. In case of lack of ovulation in a female patient can be recommended to stimulate ovulation Ovulation - How to determine as accurately as possible? Which should be carried out under the control of ultrasound.

Marina Solovyov