Before progesterone produced only in the form of oily solutions for injection, which created difficulties in its application, since the introduction of this drug is very painful. Today, natural and synthetic versions of progesterone produced in the formulations for oral administration. Examples of such drugs are utrozhestan and djufaston.
Utrozhestan or djufaston - what's the difference?
Utrozhestan (Laboratory Bezen Helska, France) is composed of natural micronized progesterone
Progesterone - norm and pathology
and released capsules that can be taken orally or be used as a vaginal suppository. Special processing allows progesterone it is well absorbed in the gastro-intestinal tract, and vagina. When receiving utrogestan inside an hour with little blood achieved therapeutic concentration of progesterone and its effect is maintained for eight hours. Vagina utrozhestan absorbed more slowly, a therapeutic concentration is reached within two to six hours, when administered twice daily it operates day.
Duphaston (international pharmaceutical company Abbott) is a synthetic analogue of the natural progesterone, dydrogesterone, which has all the properties of natural progesterone, but lacks many of its side effects. Djufaston Available in tablets for oral administration. After taking the pill active substance is absorbed into the blood, where its maximum concentration is reached after two hours.
Action utrogestan duphaston and similarly so with a lack of progesterone in the body can be assigned to any of these drugs. Utrozhestan djufaston and suppress endometrial proliferation (growth of the endometrium - mucous membrane of the uterus, which occurs in the first half of the menstrual cycle) and causes it to secrete substances necessary for the implementation of the embryo in the uterine wall. The lack of progesterone leads to violations of the menstrual cycle in the form of dysfunctional uterine bleeding and infertility. Admission progesterone tablets eliminate these violations.
After pregnancy, these drugs stimulate the production of substances necessary for the development of the embryo. They also inhibit the contraction of smooth muscle of the uterus and the immune system, thus preventing miscarriage.
When fibrocystic breast utrozhestan
Utrozhestan - corrects the deficiency of progesterone
djufaston and inhibit the action of female sex hormones estrogen, which helps to reduce swelling of the mammary glands and the resorption of small cysts.
Indications and contraindications for receiving and duphaston utrogestan
Indications for use utrogestan or duphaston are:
- menstrual irregularities related to a lack of progesterone, including dysfunctional uterine bleeding, painful menstrual irregularities, infertility;
- premenstrual syndrome;
- endometriosis - a disease associated with the growth of endometrial tissue in other tissues, such as in the muscle of the uterus, ovaries, fallopian tubes, and so on;
- lack of progesterone during pregnancy - the threat of miscarriage;
- shotty breast
Breast - the mirror Women's Health
- as replacement therapy at menopause or after surgical removal of the ovaries.
Contraindications for use utrogestan and duphaston little different. Included in the duphaston synthetic progesterone analogue dydrogesterone does not have any effect on blood clotting and virtually no adverse effect on the liver function. Therefore, it is contraindicated only with individual intolerance of components and breastfeeding.
Utrozhesten as natural progesterone has the contraindications, as increased blood clotting and a tendency to thrombosis, bleeding of unknown origin from the genital tract, incomplete abortion, hormone-dependent tumors of the breast and female genital organs, liver function abnormalities.
Relative to protvopokazaniyami utrogestan are cardiovascular diseases, renal dysfunction, diabetes mellitus
Diabetes - threatening and incurable disease
, Asthma, epilepsy, migraine, depression, disorders of lipid metabolism, breast-feeding.
Side effects of these drugs may manifest as headaches, dizziness, uterine bleeding, discomfort in the breast, liver dysfunction, limb edema, allergic reactions.
Utrozhestan and djufaston - it is efficient to hormonal drugs, they can be taken only on prescription, and after a preliminary examination. Independently apply these drugs can not.