Niacin has an active effect on the human body, so it can not have contraindications for use. Provides niacin
Nicotinic acid: what is its benefit to man?
and adverse effects that may affect the course of some diseases.
What side effects characteristic of nicotinic acid
Niacin can cause a number of side effects, they are mainly related to the release during the action of nicotinic acid histamine. At the same time there is a reddening of the face, upper body and arms, burning and tingling at the site of redness. There may also be dizziness, sudden drop in blood pressure (particularly when abrupt transition from horizontal to vertical position - if the drug is administered parenterally, ie, intramuscularly or intravenously, a condition called orthostatic hypotension). Increases the secretion of gastric juice, there are violations such as nausea, diarrhea, itchy skin.
Not always the side effects require discontinuation of the drug, in the absence of contraindications to the use of his body gradually adapts to the release of histamine and has not reacted rapidly and gradually all the effects associated with histamine, come to naught.
But sometimes it is necessary to revise the designated dose and duration of use of nicotinic acid. If you apply nicotinic acid for a long time, it may appear a violation of appetite, vomiting, diarrhea, abnormal liver function (including its fatty degeneration), irritation of the gastric mucosa with the formation of erosions and ulcers (especially if the patient suffers from gastric ulcer and duodenal intestine), disorders of the cardiovascular system (lower blood pressure, cardiac arrhythmia), impaired renal function, worsening of diabetes.
Contraindications to the use of nicotinic acid
Contraindications for the purpose of nicotinic acid is not so much, however, they need to be taken into account, otherwise avoid complications.
For reception of nicotinic acid is contraindicated during exacerbation of diseases of the gastrointestinal tract, especially in the acute gastric ulcer and duodenal ulcer. The stimulation of gastric acid secretion in conjunction with the expansion of blood vessels can lead to an exacerbation of peptic ulcer disease and gastrointestinal bleeding. It is dangerous to prescribe niacin and exacerbation of ulcerative colitis (inflammation of the colon) - it also may cause bleeding.
Not allowed the use of nicotinic acid tablets under the age of two years, and parenterally - for children of all ages. The sharp expansion of blood vessels can cause the same sharp decline in blood pressure, up to the collapse. C care should be taken into nicotinic acid in glaucoma, gout
Gout - the "disease of kings"
, Kidney function and liver function, low blood pressure, a tendency to bleeding.
Parenteral administration of nicotinic acid is not recommended for very high or low blood pressure, atherosclerosis, certain metabolic disorders
Metabolism: The basis of life of all living things
(e.g., in gout), severe kidney disease with a significant reduction of their function.
Features of treatment with nicotinic acid
It is believed that it is not necessary to use nicotinic acid for the treatment of disorders of lipid metabolism in patients with diabetes
Diabetes - threatening and incurable disease
- Changes in the blood vessels in diabetes mellitus can cause various complications in the application of nicotinic acid.
Prolonged treatment with nicotinic acid and its use of high doses required to follow the work of the liver - a violation of its features are found in such cases often enough.
If there are signs of toxic effects of nicotinic acid on liver cells, it is recommended to include foods rich in methionine. Methionine is an essential amino acid and has a lipotropic effect - removes excess fat from the liver and prevents the formation of fatty liver. Methionine rich dairy products, particularly cheese.
Nicotinic acid injections are very painful, so if you have the opportunity to appoint a nicotinic acid inside, this form should be preferred. The ingestion dose is better to increase gradually - so you can avoid the side effects. Take the pill should be after a meal, not liquid and wash down with water.
Caution is needed when assigning nicotinic acid drugs simultaneously lowering blood pressure (it may occur sharp reduction) and anticoagulation (nicotinic acid also reduces blood viscosity, which, in combination with dilation of blood vessels may contribute to bleeding).
Niacin is a vitamin, however, it has enough of contraindications and side effects, so it must appoint a physician.