Prednisolone - this is one of the most popular glucocorticoids. It is used to relieve inflammatory and allergic processes, especially if they are accompanied by severe pain, or unbearable itching. Prednisolone suppresses the growth of tumors, the immune system (which is especially important in autoimmune processes) and has a number of other properties.
How "works" prednisone
Human adrenal hormones produced glucocorticosteroid (GCS), which govern the operation of almost all organs and body systems. As drugs available today synthetic corticosteroids, including prednisolone.
Prednisolone has an impact on all types of metabolism. It inhibits the breakdown of proteins in the inflammatory focus, promotes the formation of glucose
Glucose: The energy source
of the products of protein metabolism, which leads to a reduction in the amount of proteins in blood plasma and to suppress the growth of children. It increases the collapse, but at the same time the synthesis of fat - fat is stored in the form of fat reserves and redistributed in the body. The increased amount of blood glucose is formed, for its assimilation fabrics produced increased amounts of insulin
The principles of action of insulin - the science of saving lives
.
Prednisolone has a significant impact on mineral metabolism: it delays the body's sodium and water, removes potassium and calcium, washing away the last of the bones and cause osteoporosis (thinning and increased fragility of bones).
Prednisolone inhibits the synthesis and entry into sites of inflammation and allergies of biologically active substances that cause these processes, including histamine, prostaglandins, interleukins, and so on. This causes a pronounced anti-inflammatory and antiallergic effect, reduces swelling, pain and itching. But at the same time it decreases the amount of prostaglandins in the gastrointestinal tract (GIT), which protects it from the wall of different effects, which leads to the formation of ulcers and erosions of gastric bleeding.
Shock resistance effect of prednisolone developed by intensifying their action of adrenaline, which causes a spasm of blood vessels and increased blood pressure.
Immunosuppressive (immunosuppressive) effect is due to the suppression of both cellular and humoral immunity.
Prednisolone also inhibits proliferation - the multiplication of tissue cells that are actively used in the treatment of cancer.
Which diseases apply
Prednisone prescribed for hard occurring inflammatory processes, especially if they are accompanied by pain. For example, it is often necessary to prescribe for diseases of the spine and joints, such as arthritis, arthrosis, ankylosing spondylitis, and so on. Where other drugs powerless, prednisolone easily removes effects of inflammation, swelling and pain.
Prednisolone and chronic allergic diseases such as bronchial asthma, allergic skin diseases (atopic dermatitis, atopic dermatitis), allergic rhinitis. In acute allergic processes, some as anaphylaxis or angioedema prednisone administered intravenously and quickly stops the development of allergic process.
Prednisolone is used also in systemic connective tissue diseases (systemic lupus erythematosus, scleroderma), rheumatism and rheumatoid arthritis, cancer (except skin cancer) and many other diseases that require the effect of GCS.
When prednisone can not be used
Do not use Prednisolone if you are sensitive to it of the patient (and this happens, and rarely Chol), gastric ulcer or duodenal ulcer, osteoporosis, severe diabetes, or high blood intraocular pressure, thrombophlebitis. And in some endocrine diseases that can significantly increase the weight of prednisone under the influence (for example, Cushing's disease), acute infectious processes of any origin, psychosis and during breast
Breastfeeding - a personal choice
feeding.
In pregnancy, prednisone is used only for health reasons.
What side effects causes
Side effects very much, especially with prolonged use of high doses of prednisone. It ulcerative processes in the stomach, high blood pressure, a sharp decline in immunity (the spread of infection and slow healing of wounds), exhaustion of the adrenal cortex and endocrine disorders (eg Cushing's disease), diabetes mellitus
Diabetes - threatening and incurable disease
, Excretion of potassium (which leads to a weakening of the heart muscle), osteoporosis, thrombosis, the occurrence of pustular rash on the skin, stretch marks, petechiae, psychosis, impaired growth in children.
Prednisone - is a highly effective drug that has many side effects.
Galina Romanenko