Contraindications to receiving metronidazole

Metronidazole is contraindicated for use in the I trimester of pregnancy. Use of the drug in the II and III trimester is possible only when the intended benefits to the mother outweighs the potential risk to the fetus.

If necessary, use of metronidazole during lactation breastfeeding should be discontinued, since metronidazole enters the body of a child with breast milk. If the doctor prescribes a one-time receiving metronidazole breastfeeding should stop, and then resume after a short time.

Avoid the simultaneous application of metronidazole and indirect anticoagulants. If necessary, their joint purpose should carefully monitor the prothrombin time and install the appropriate dose of anticoagulant.

Caution should be used in conjunction with metronidazole drugs lithium, while necessary to monitor the concentration of lithium and creatinine Creatinine - will talk about the work of the kidneys   in blood plasma.

Metronidazole should not be used concurrently with astemizole and terfenadine. Metronidazole can be used no earlier than 2 weeks after receiving disulfiram. It is also not recommended to take metronidazole along with medications containing alcohol, such as cough syrup Cough syrup - how to choose the best?   and colds.

If you are taking any of the drugs listed above, be sure to tell your doctor before taking metronidazole.

Metronidazole may affect the results of certain lab tests (eg, liver function tests, and analysis of the level of glucose trigletseridov Glucose: The energy source   plasma), so while taking this drug should refrain from carrying out analyzes or specify the fact of the use of metronidazole.

In case of overdose of metronidazole, which are symptoms of nausea, vomiting, seizures and peripheral neuropathy, you should immediately contact your doctor or in the "ambulance."

Cautions

In no case do not give metronidazole others without doctor's permission.

In the treatment of certain infectious diseases, sexually transmitted diseases (eg, trichomoniasis), treatment with metronidazole Metronidazole - what is it?   You must complete both sexual partners to avoid further spread of the infection. The treatment should abstain from sex or use condoms.

This medication should be used only for the treatment of this particular disease. Do not use it in the future for the treatment of other infectious diseases, in this case, you may need quite a different medicine.

Periodically perform a blood test to check the effectiveness of treatment and monitor the overall health, as well as for side effects.

If you miss a dose

If you did not take a tablet of metronidazole in due time, take it as soon as you remember. If soon the need to take the next dose, skip this method and continue to take the drug on a fixed schedule. In no case do not take a double dose to make up for a missed appointment.

Safekeeping

Metronidazole tablets should be stored at room temperature below 25 ° C in a dry, dark place. Metronidazole capsules should be stored at temperatures below room temperature (15-25 ºC). Do not store in the bathroom metronidazole. All medicines should be kept out of the reach of children and pets.

Do not dispose of residues of metronidazole in tablets or capsules down the toilet or sink. After the expiry date dispose medication as instructed. Do not use after the expiration date printed on the package.

Trichopolum - effective antiparasitic and antimicrobial broad spectrum of action. Trichopolum actively inhibits the development of protozoa pathogens trichomoniasis, giardiasis, amoebic dysentery (Trichomonas, dysentery amoeba, giardia) and has antimicrobial activity against anaerobic (emerging in the absence of oxygen) bacteria. Trichopolum produced in the form of tablets, vaginal tablets and solutions for intravenous administration, ampoules and vials.

pharmachologic effect

Trichopolum - it antiprotozoal agent. The active substance Trichopolum - metronidazole - active against protozoa and anaerobic bacteria. By Trichopolum sensitive Giardia, Trichomonas Trichomonas - leads to infertility , Balantidiums, amoeba, Bacteroides, fuzobakterii, clostridia.

Aerobic bacteria are insensitive to metronidazole. In combination with amoxicillin Trichopolum active against Helicobacter pylori. According to experts, amoxicillin prevents the formation of resistance of Helicobacter pylori to metronidazole.

Pharmacokinetics

Trichopolum sufficiently rapidly absorbed in the digestive tract and reaches its maximum concentration after 1, 5-3 hours after administration, reaching a maximum speed of concentration depends on the dose. Admission Trichopolum simultaneously with food may worsen the process of absorption and increase the time required to achieve maximum plasma concentration. Trichopolum penetrates the blood-brain and the placental barrier sufficiently uniformly distributed in the body, entering into the bile, vaginal secretions, saliva, semen, cerebrospinal and peritoneal fluid, liver tissue, brain.

Trichopolum Metabolism occurs in the liver, the active metabolites are also able to act antibacterial and antiprotozoal. The half-life is 6-8 hours Trichopolum, with severe liver pathologies half-life can be increased. Withdrawal Trichopolum carried out mainly by the kidneys (80%). When treating Trichopolum can change the color of urine to red-brown or dark in color, due to the presence of dyes, resulting from the metabolism of the drug.

Indications

Indications Trichopolum Trichopolum - indications for use are wide enough   include:

• and trichomoniasis Trichomonas urethritis in women;
• Trichomonas urethritis in men;
• amebiasis;
• giardiasis;
• vaginitis caused by susceptible microorganisms to Trichopolum;
• surgical infections caused by organisms susceptible to Trichopolum;
• prevention of surgical site infections (particularly infections of the gastrointestinal tract and urinary tract);
• in the complex therapy to eliminate Helicobacter pylori (exacerbation of chronic gastritis, ulcerative gastritis and duodenal ulcer);
• alcoholism;
• For external use in the treatment of acne Acne treatment: how to get rid of blackheads , Bacterial vaginitis, venous ulcers.
• Other infections caused by susceptible microorganisms.

Dosage

Trichopolum prescribed for oral use in adults and children over twelve years at the rate of 7, 5 mg per 1 kg of body weight every six hours or 250-750 mg 3-4 times a day. For children under the age of twelve dosage is 5 - 16 7 mg per 1 kg body weight 3 times per day. Duration of treatment is determined individually. Dosage Trichopolum depending on the type of infection:

• Anaerobic infections:

prevention: an initial dose of 1-1, 5 g once, followed by 0.75 g per day, by dividing the daily dose into 3 doses.

treatment: 0, 75-1, 5 g per day by dividing the daily dose into 3 doses, for children from 6 to 12 years 0.375 g, divided into 3 doses.

Trichopolum recommended to be taken during or immediately after a meal, a course of treatment usually lasts more than a week. Trichopolum assigned as a part of complex treatment and as monotherapy.

• Trichomoniasis:

For successful treatment of trichomoniasis require treatment of both partners.

treatment of trichomoniasis in women: 1 tablet twice a day, and 1 vaginal suppository once a day for 10 days.

treatment of trichomoniasis in men: 1 tablet twice a day, for 10 days. Other schemes are possible: 3 tablets (0 75g) in the morning and 5 tablets (1, 25 g) in the evening for 2 days, or eight tablets (2 g) Trichopolum once.

• Bacterial vaginitis:

1 g per day in 2 divided doses (0, 5 g in the morning and 0, 5 g in the evening), during the week, or 2 g once.

• Amoebiasis:

at 0, 5 g three times a day for a week; children whose weight more than 20 kg dose is calculated according to the weight, a single dose of 10 mg per kilogram of body weight three times a day therapy usually lasts for a week.

• Eliminating Helicobacter pylori:

Trichopolum included in the circuit to eliminate Helicobacter pylori, the recommended daily dose of 0, 5 g, divided in 2 doses, a course of 1-2 weeks.

Patients with liver disease need special assignment scheme Trichopolum as biotransformation occurs in the liver and impaired liver function may result in accumulation of metronidazole and hepatic coma. In these patients Trichopolum Trichopolum - he treats?   It should be applied at a dose which is 30% of normal. Patients with kidney failure usually does not require dose adjustment in case of passing hemodialysis, after undergoing the procedure should be repeated reception Trichopolum.

For elderly patients require dose reduction Trichopolum, when using the drug in average daily doses requires careful medical supervision, use of metronidazole in high dosages in these patients is not desirable.