Prednisone - is a synthetic glucocorticoid drug, which has all the advantages and disadvantages of the drugs in this group. Its side effects are enhanced by long-term use at high doses, so try prednisone given only in case of emergency and short courses.

Adverse effects of prednisolone by metabolic and endocrine

With prolonged use of prednisolone in the plasma there is a deficiency of proteins. And as prednisone Prednisolone - against inflammation, allergy and pain, but with complications   plasma normally associated with a protein, when there is a deficit of toxic free progesterone Progesterone - norm and pathology . At deficiency of plasma protein disrupted growth and sexual development of children and adolescents.

It increases the amount of glucose in the blood, which has a negative effect on diabetic patients. Enhances decay and at the same time the formation of fats, which are deposited in the tissues, creating extra weight and irregular shape configuration. Mineral metabolism is disturbed by the fact that the body is derived from potassium (reduced myocardial contractility) and calcium (formed osteoporosis - thinning of the bones). In the body, delayed sodium and water - this causes the occurrence of edema.

Part of the endocrine system is the suppression of the hypothalamic-gipofizano-adrenal system. This leads to the dysfunction of the adrenal glands and the formation of the syndrome Cushing's, as well as to suppress the secretion of pituitary gonadotropins, menstrual irregularities and infertility in women, and sexual dysfunction in men. Disturbances of carbohydrate metabolism cause the development of steroid diabetes or symptoms previously asymptomatic diabetes.

Side effects of prednisone from the cardiovascular system

Loss of body potassium affects the condition of the heart muscle (myocardium). This can lead to cardiac arrhythmia and bradycardia (very slow heart rate, up to a cardiac arrest). Violation of cardiac contractility can cause the development of symptoms of heart failure, when the heart is unable to cope with the load and there is stagnation of blood in the peripheral vessels. The process is exacerbated by the fact that the body is delayed sodium and water - it helps to increase blood volume and further stagnation.

Simultaneously, under the influence of prednisolone occurs spasm of blood vessels and increased blood pressure, it creates the preconditions for the further stagnation of blood and blood clotting increased, ie tendency to form blood clots. Coronary thrombosis and cerebral vessels - the main cause of heart attacks and strokes. Thus in patients with acute myocardial infarction in patients receiving prednisone occurs spread necrosis (tissue death), and slow the formation of scar tissue, which can lead to rupture of the heart muscle.

Side effects of prednisone on the central nervous system and organs of vision

From the body of chronic administration of prednisolone may develop cataracts, increased intraocular pressure, optic nerve damage, metabolic disorders of the cornea, joining infection.

Side effects of prednisone from other organs and systems

On the part of the gastrointestinal tract are possible violation of appetite, nausea, vomiting, abdominal distension, hiccups. Happen erosive and ulcerative lesions of the gastrointestinal tract and bleeding from that area, inflammation of the esophagus and pancreas, sometimes develop transient liver function abnormalities.

From the musculoskeletal system may occur osteoporosis (it may be accompanied by fractures), violations of bone growth in children and adolescents, muscle weakness and reduction of muscle bulk (muscle atrophy), rupture of tendons of muscles and ligaments (they consist of connective tissue that thins under the action of prednisone).

On the skin when applied topically and prednisolone injection site may occur petechial hemorrhages, areas of increased or decreased pigmentation, thinning of the skin (skin atrophy), stretching (a consequence of rupture of collagen fibers), there may be a rash pustular, and fungal diseases.

Prednisolone - a drug that can produce serious side effects.

Galina Romanenko

Trichopolum - a drug which is used not only to treat diseases caused by protozoa, but also for the treatment of bacterial infections (e.g., intestinal infections, infections of the urogenital system, etc.), as well as in the treatment of gastric ulcer and duodenal ulcer.

How does Trichopolum

Trichopolum (INN - metronidazole) - a drug that inhibits the ability to live simple and certain types of anaerobic (without developing air) bacteria. In addition, it suppresses the livelihoods of Helicobacter pylori - the infectious agent that causes stomach ulcers and duodenal ulcers.

Mechanism antiprotozoal and antibacterial action Trichopolum involves a violation of the structure of DNA sensitive microorganisms. Sensitivity to show him Trichomonas vaginalis, Giardia, intestinal amoeba and so on, as well as the microorganisms that cause intestinal and urogenital infections. Insensitive to Trichopolum aerobic (developing under air) bacteria and pathogenic fungi.

Application for trichomoniasis

Trichomoniasis - this is the main indication for the use of Trichopolum. Trichomonas vaginalis exhibit a high sensitivity to the drug. Trichopolum used to treat not only the acute but also chronic, long-flowing trichomoniasis, which is often complicated by other, including bacterial infections.

If trichomoniasis Trichopolum appointed interior adults to 250 mg twice a day, the course of treatment - ten days. After the treatment is carried out laboratory monitoring - once a month several times.

Use of other diseases caused by protozoa

Trichopolum used for intestinal giardiasis in children. In adults, giardiasis rarely causes any symptoms of the disease, and in children it often leads to the emergence of nausea, vomiting, abdominal pain and so on. In addition, giardiasis can be lubricated now other more serious diseases of the gastrointestinal tract. Therefore, giardia is still desirable to remove from the body.

When giardiasis tripopol well appointed inside. Adults and children after ten years prescribed 250 mg twice a day for five to ten days (duration of treatment is determined by the physician). Children from six to ten years prescribed 185 mg twice a day, two to six years - 125 mg twice daily. When the treatment is over, control is assigned to multiple laboratory tests at an interval of one-half months.

Treat Trichopolum and intestinal amebiasis and amebic abscess Abscess - why it is so dangerous ulcers?   liver. This disease requires a somewhat larger dose Trichopolum, it is prescribed 250 mg three times a day for ten days. Babies suffering from amebiasis, Trichopolum appointed at the rate of 35 mg per kg body weight - the daily dose, which must be divided into three stages.

Trichopolum in bacterial vaginosis

Bacterial vaginosis - vaginal bacteria overgrowth is Dysbacteriosis vagina - how to fight? Which often develops due to lower immunity and uncontrolled use of antibacterial agents. This suppresses the natural vaginal flora The microflora of the vagina: purity   (mainly lactobacilli) and multiplies pathogenic microflora. It appears advent of bacterial vaginosis discharge with an unpleasant "fishy" odor. Bacterial vazinoz at any moment can turn into infectious inflammation of the vagina, so it is subject to compulsory treatment.

The most common cause of bacterial vaginosis are gardnerelly - bacteria that are sensitive to Trichopolum.

Bacterial infections

Sensitivity to Trichopolum often show anaerobic bacteria that cause infectious and inflammatory diseases of urinary organs - the kidneys and urinary tract, the uterus and its appendages, the external genitalia. Sometimes these diseases develop after abdominal operations.

For the treatment of infectious and inflammatory diseases Trichopolum usually given intravenously three times a day. The course of treatment depending on the patient can last from one to three weeks.

When diseases of the genitourinary system caused by a mixed bacterial infection (anaerobic and aerobic), then Trichopolum Trichopolum - he treats?   administered with any antibiotic, which are sensitive infectious agents.

In gastric ulcer and duodenal ulcers (the causative agent - Helicobacter pylori sensitive Trichopolum) Trichopolum given in combination with amoxicillin.

Trichopolum - an effective, time-tested antiprotozoal and antibacterial drug.

Galina Romanenko