Actovegin - a drug that improves metabolism Improves metabolism and losing weight without dieting   in tissues and promotes regeneration. Under the influence of aktovegina improves glucose uptake Glucose: The energy source   fabrics and supplying them with oxygen. Aktovegin ampoules used for the treatment of the consequences of such serious diseases such as cerebrovascular accident, stroke, traumatic brain injury and others.

How does aktovegin ampoules

Aktovegin produces Austrian pharmaceutical Nycomed in various dosage forms including as a solution for injections in ampoules of 1 and 5 ml (40 mg in 1 ml). Aktovegin prepared from calf blood by dialysis and ultrafiltration, so it contains only physiological substance. During the processing of the preparation remain compound (low molecular weight peptides and amino acid derivatives) with a molecular weight less than 5000 daltons.

Aktovegin improves tissue glucose uptake (source energy required for biochemical reactions that are part of the metabolic processes) and consumption of oxygen, which leads to faster metabolism Metabolism: The basis of life of all living things   and rapid recovery of tissue damaged by disease or injury.

Which diseases prescribed

Aktovegin ampoules appoint:

• in violation of cerebral circulation, including in ischemic stroke;
• when metabolic disorders in the tissues of the brain;
• in traumatic brain injury;
• in violation of the peripheral circulation (arterial and venous) - artery patency (eg, when occlusive disease) and stagnation in the veins (eg, with varicose veins complicated by trophic ulcers);
• in disorders of the peripheral nervous system associated with diabetes (diabetic polyneuropathy);
• at long flowing trophic ulcers, bedsores, wounds, burns;
• when radiation injuries of the skin and mucous membranes (for example, against the background of radiation therapy of cancer), including for the prevention of injuries;
• during pregnancy when there is insufficient oxygen supply of the fetus (fetal hypoxia), which may lead to serious violations on the part of the brain of the fetus.

Who does not prescribe the drug

Aktovegin ampoules not indicated in severe cardiovascular disease, when the heart muscle is unable to cope with its function, which leads to edema, including pulmonary edema. You can not assign aktovegin Aktovegin - without fear of negative consequences   ampoules in the fluid retention of any origin, including those with severe kidney disease and urinary tract infections that are accompanied by violation of excretion of urine and urinary retention. Not applicable aktovegin case of hypersensitivity to it the body of the patient.

Aktovegin administered with caution in the case where the patient blood revealed an increased content of sodium and chlorine.

Side effects

Particularly dangerous reactions such drug when administered intravenously, as they often occur in the form of anaphylactic shock. Therefore, prior to intravenous drip is recommended to test an intramuscular injection (2 ml). If aktovegin administered intramuscularly, it should be administered slowly and not more than 5 ml, as the solution is hypertonic (concentrated) and can irritate the tissue.

Other side effects, as well as cases of overdose have been identified.

Features introduction aktovegina ampoules

Aktovegin ampoules administered intravenously (bolus or infusion, in the latter case aktovegin diluted with saline or 5% glucose) at a rate of 2 ml per minute, intraarterially, but may be administered intramuscularly. With frequent intravenous administration aktovegina necessary to monitor the state of the water-salt metabolism in the body of the patient - may cause edema.

Aktovegin ampoules has a yellowish color of varying intensity - it depends on the characteristics of animal blood, and does not affect the quality of the drug. But if the solution in the vial is cloudy or there are floating flakes, it can not be used. It is also impossible to store the opened vial and added to the solution for infusion, any other medications.

Keep the vials with a solution aktovegina should be protected from light, out of reach of children at or above 25 ° C.

Aktovegin ampoules can be used only on prescription.

Galina Romanenko

Aktovegin - is deproteinized extract of calf blood, which in 1996 produced by the Austrian company Nycomed. According to the manufacturer, the raw material is the blood of calves younger than 8 months. This drug is widely used in cerebrovascular diseases, and for treating a variety of disorders, including rheumatic diseases.

Effects aktovegina

• Aktovegin improves anaerobic respiration, which has a positive effect on the fabric, experiencing metabolic failure.
• Ingredients aktovegina improve the transfer of glucose in the body. In patients with insulin-dependent diabetes aktovegin significantly slows the development of diabetic angiopathy.
• Aktovegin stimulates metabolic processes in the body.
• This drug has a positive therapeutic effect on patients suffering from peripheral cerebrovascular disorders. This effect is associated with improved vascularization and development of collateral circulation.
• Aktovegin has immunomodulatory effects.
• Aktovegin improves the delivery of oxygen to the tissues of the body, reduces ischemic tissue damage, and has an indirect impact on the synthesis of cells.
• Aktovegin improves the quality of life for patients with chronic disorders of the heart and helps with rheumatoid arthritis, systemic lupus Systemic lupus erythematosus: how to recognize the disease , Systemic scleroderma Scleroderma - affects all the organs   and many other diseases.

Active components aktovegina contribute to a better absorption of glucose Glucose: The energy source   brain and skeletal muscles, improving the transport of glucose into the cells by controlling the operation GluT1 transporter protein. By activating pyruvate dehydrogenase, aktovegin improves glucose utilization. It also improves the absorption of oxygen hypoxic tissue, and as a result, to protect these tissues from damage.

Aktovegin also stimulates cell metabolism, as evidenced by the increased absorption and utilization of oxygen and glucose. These actions are related, as they improve the synthesis adenazintrifosfata (ATP), thus ensuring a better supply of energy cells. This makes aktovegin useful in conditions such as hypoxia and deficiency of energy substrates. Aktovegin promotes renewal and regeneration of tissues, and one of its secondary effects is to improve blood circulation.

Safe whether aktovegin?

Security aktovegina evaluated on several important features:

• Using animals as a raw material. According to international standards, the best raw materials for medicines are animals from countries free of bovine spongiform encephalopathy in cattle (BSE), or mad cow disease Rabies - the forecast is unfavorable And having respective control methods of animal health. Animals that are used to manufacture aktovegina were born, raised and hammered in Australia, the country officially recognized free of BSE.
• Body parts and fluids of animals used as raw materials are divided into four categories - from the first, characterized by high infectivity (this category includes, for example, the brain), to the fourth, the safest, which includes blood and milk. Aktovegin made from calves' blood.
• Age of animals is of great importance: the younger they are, the safer use them as raw materials. Animals which serve as raw materials for the production of aktovegina under the age of eight months, they have never given feed made from processed animal corpses, all of them are considered fit for human consumption, and have a veterinary certificate. In addition, the health of the parents calves also meet safety requirements.