Nonsteroidal anti-inflammatory drugs (NSAIDs)

NSAIDs - a medication that has analgesic, antipyretic and anti-inflammatory properties at the same time expressed. Since the anti-inflammatory properties of these drugs are predominant in strength approaching action to the action of steroid hormonal compounds, but they have a steroid structure is absent, they were called non-steroidal anti-inflammatory drugs.

The first representative of this group was aspirin, after these drugs were produced many and each of them has its own characteristics. Irritant effects of these drugs on the gastrointestinal tract, with good anti-inflammatory effect led pharmacologists to think about how to get rid of the side effects.

How does nimesulide

Nimesulide - the first drug of a new generation of NSAIDs, the mechanism of action is associated with selective inhibition of the enzyme cyclooxygenase II (COX-II). The enzyme cyclooxygenase (COX) is divided into two forms of COX I and COX II. First protects the stomach lining against any impacts, and the second promotes inflammation. When a polling only COX II inhibition of inflammation is reduced, as well as the amount of COX-I is not changed, the risk of complications from the gastro-intestinal tract is minimized.

In addition to anti-inflammatory, analgesic and antipyretic properties of nimesulide has the ability to inhibit platelet activating factor Platelets - what they are for the body?   (and thus prevent the increase in blood clotting and thrombus formation), tumor necrosis factor alpha (excess of this factor is expressed when inflammation) inhibit the action of histamine (decreases the severity of allergic reactions Allergic reactions: how to understand why you tickle in the throat Including bronchospasm).

After oral administration, the drug is well absorbed from the gastrointestinal tract, its maximum plasma concentration is reached within 1, 5-2, 5:00 after taking the drug.

In some cases, you need to take nimesulide

Nimesulide is used:

• If disturbed severe pain in the joints Joint pain - how to understand what is going on?   in inflammation of the joints Inflammation of the joints - how to relieve the pain?   (including rheumatoid arthritis), age-related changes in the joints (osteoarthritis), inflammation of the tendons (tendovaginitah), inflammation of the synovial joints (bursitis);
• as an antipyretic agent for various infectious diseases;
• as an analgesic in the postoperative period, trauma;
• as an analgesic and anti-inflammatory agent in diseases of the ear, nose and throat, dentistry, gynecology; the effect of the appointment of nimesulide occurs rapidly in the first 15 minutes after taking the pill, so it can be used to treat acute pain (headache, toothache, painful menstruation, and so on).

Nimesulide tablets taken by mouth with plenty of water, preferably before meals. When hypersensitivity stomach nimesulide taken at or after mealtime.

Nimesulide usually does not give side effects. In rare cases, there may be nausea, vomiting, stomach pain, diarrhea, pruritus, urticaria, bronchospasm (shortness of breath with difficulty).

Cases of overdose have not been described.

At present, we developed and successfully applied a few dozen NSAIDs that enables an individual approach to the choice of the drug at each administration of these drugs in this group. Despite the fact that at the heart of all the action of NSAIDs is one mechanism - inhibition of COX activity, the severity of the anti-inflammatory, analgesic and antipyretic effects and side effects, they may be different.

Thus, nimesulide has a high safety and efficiency, the various mechanisms of anti-inflammatory and analgesic action, however it should be assigned to the most promising for application in rheumatological practice, and in the treatment of many other diseases.

  Galina Romanenko

The causes of pain in the joints

Joint pain is often not even because the joints are ill, but because the joints react to any subtle intoxication. So, joints ache when purulent tonsillitis, several infectious diseases, severe allergic and inflammatory processes, some blood diseases and so on.

Joint pain may occur at various disorders of the central nervous system under the influence of stress. Such pains are aggravated by nervous stress and tested while taking sedatives.

Proper joint disease may also cause pain. All joint diseases can be divided into inflammatory, metabolic, and degenerative diseases of soft tissues surrounding the joints. To understand why you have sore joints, you need to see a doctor and get tested.

Inflammatory joint pain

When inflammation of one or more joints has pains called inflammatory and have distinct characteristics. A feature of this pain is that they are combined with swelling and redness of the joint and usually occur after a long period of immobility of the patient, i.e. night and morning. The latter feature is due to the fact that in a stationary state in the joint collects inflammatory liquid that irritates the nerves that innervate the joint is more swollen and soft tissues surrounding the joint, which further exacerbates the situation.

Relief for inflammatory joint pain brings the removal of edema and inflammation, ie the treatment of the disease itself. Once the swelling decreases, and decrease pain. But in some cases, pain may be very strong. In such cases it is advisable to keep the affected joint during sleep Dreams: how to understand our dreams   in an elevated position (the smaller increases swelling) and take various painkillers. Very well suited in such cases, non-steroidal anti-inflammatory drugs (NSAIDs, such as diclofenac), which not only reduces pain, but also to reduce tissue inflammation. Good help and physiotherapy procedures such as electrophoresis and phonophoresis with various painkillers and others.

Arthritic pain of rheumatism and rheumatoid arthritis

As rheumatism and rheumatoid arthritis Arthritis - a variety of forms and complications   are diseases which are based on the infectious-allergic process. But if rheumatic joint disease is relatively short-lived and the like without any consequences (or rather, "switches" on the heart), rheumatoid arthritis that lasts for years and leads to numerous changes in the joints and full disability of the patient. And another difference: rheumatism "loves" the large joints (eg, knee), and rheumatoid arthritis What is arthritis - when it hurts everywhere   - Small (joints of the hands and feet) and then "moved" into large, completely changing their appearance.

Pain in the joints of rheumatism is not very difficult to remove, it is enough to remove the inflammatory process with the help of antibiotics and NSAIDs. Pain as rheumatic arthritis are exhausting and difficult to treat. Patients are forced to constantly take NSAIDs, which irritate the stomach lining and can lead to the occurrence of peptic ulcer disease. Severe pain in rheumatoid arthritis forced to appoint hormones Hormonal treatments - not only contraceptives That at some time relieve pain, but have their own problems and complications. Sometimes, in order to reduce pain to the patient is applied to the joint of the fixing bandage, which holds the joint in a convenient and not too painful position.

"Mechanical" pain in the joints

"Mechanical" referred pain arising from exchange-degenerative diseases of the joints. The cause of these diseases in a young age are generally injury or consequences of inflammation in joints, in old - age metabolic disorders. Such pains are the result of the destruction of the cartilage that covers the joint.

"Mechanical" pain usually have a lower intensity than inflammatory, and amplified at high physical loads, especially towards the end of the day. At rest, such pains are reduced or disappear altogether.

Patients with metabolic-dystrophic diseases of the joints must be clearly aware that in order to reduce joint pain need to rest periodically. NSAIDs help, warming procedures, training of medical gymnastics and massage.

Joint Pain - is a signal of distress in your body, why it occurred and how to remove only a doctor can understand.

Galina Romanenko