Diprospan - drug glucocorticosteroid (GCS), which has potent anti-inflammatory and anti-allergic effect, suppresses the immune system. Suitable diprospan for treating the inflammatory process in the joints, intestines, allergic diseases, malignant tumors, and so on.
The mechanism of action diprospana
Diprospan (active substance - Betamethasone) - a glucocorticosteroid drug which produced pharmaceutical firm Schering Plough as a suspension for injection, 1 ml of which contains 2 mg of betamethasone disodium phosphate (it provides a quick onset of therapeutic effect) and 5 mg of betamethasone dipropionate (provides long-term effect).
Diprospana mechanism of action is based on the fact that it inhibits the release of biologically active substances responsible for inflammatory and allergic processes. Antishock and anti-toxic effect diprospana depends on high blood pressure, reduce the permeability of the walls of blood vessels, activation of liver enzymes which are involved in neutralizing the toxins.
Thus, diprospan has anti-inflammatory, antiallergic, antishock, antitoxic action and suppresses the immune system (immunosuppressive effect).
It also has an impact on all organs and systems of the body, such as hormones: it suppresses the secretion of thyroid-stimulating (TSH - stimulates the secretion of thyroid hormones), adrenocorticotropic (ACTH - regulating the secretion of your own GKS the body in the adrenal cortex) and follicle stimulating hormone (FSH - stimulates oocyte maturation in the ovary) pituitary hormones.
Diprospan increases the excitability of the central nervous system to inhibit the production of eosinophils and lymphocytes (blood cells responsible for immunity and allergy), but increases the formation of red blood cells. It inhibits growth of connective tissue at the site of inflammation, that is, the formation of adhesions and scarring.
This affects all types of metabolism. Including reduces the amount of protein in blood plasma increases protein breakdown in muscle tissue, redistributes fat (fat accumulates mostly in the hands, face, abdomen), increases blood cholesterol, increases the absorption of carbohydrates from the intestine, increases glucose uptake
Glucose: The energy source
from the liver into the bloodstream. Does he in the water-salt metabolism, delaying the body's sodium and fluid (it leads to edema), bringing potassium (disrupted the heart muscle), reducing the process of absorption of calcium from the intestine and washing out the calcium from bone tissue (bones become fragile - osteoporosis) .
Indications for use
Diprospan used in the treatment of serious diseases, when it glucocorticosteroids can facilitate the condition of patients. This severe inflammation of the joints (arthritis, including rheumatoid arthritis), degenerative-dystrophic diseases of joints and spine (osteoarthritis, low back pain), severe ulcerative necrotic processes in the intestine (ulcerative colitis), systemic connective tissue diseases (scleroderma, lupus erythematosus and others), keloids (bright pink, are prone to the growth of scars), allergic diseases (atopic dermatitis, allergic contact dermatitis, bronchial asthma and others), cancer, alopecia areata (patchy hair loss).
Dipospan contraindicated if you are hypersensitive of the drug by the body of the patient, with systemic fungal disease (GCS contribute to the growth of fungal microflora) and during the feeding of the child
Breastfeeding - a personal choice
feeding. You can not enter diprospan intravenously or subcutaneously. Intra its introduction contraindicated in infectious processes in the joints and in the spine.
Precautions diprospan prescribed for reducing thyroid function
The thyroid gland - is responsible for your hormones
, Cirrhosis, herpes eye infection, ulcerative colitis (under the threat of perforation of the intestinal wall), purulent infection of any localization, gastric ulcer and duodenal ulcers, kidney function, high blood pressure, osteoporosis, severe muscle weakness, certain blood diseases.
Application diprospana during pregnancy is not desirable due to the lack of controlled studies of its safety.
Like all other SCS diprospan has many side effects that are often dependent on the dose. Since diprospan affects all types of metabolism
Metabolism: The basis of life of all living things
It can adversely affect all organs and systems, so diaprospan always be used with caution and only in the presence and absence of contra-indications for its use.
Any glucocorticosteroid drugs, including diprospan, impact on the body, comparable to surgery.