Elevated prolactin during pregnancy is all women, as this hormone is actively involved in the normal development of the pregnancy and prepare for breast-feeding mothers. Prolactin is especially necessary for the formation of the respiratory system of the fetus.
Why pregnancy prolactin
Prolactin - a hormone of the anterior pituitary, which is involved in the formation and functioning of the female reproductive system. During pregnancy, the amount it increases as it is necessary for both mother and child.
Prolactin stimulates growth and development of the mammary gland, the secretion of progesterone
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Which is particularly necessary at the beginning of pregnancy, since it prevents the interrupt. Prolactin is also involved in the water-salt metabolism, during pregnancy it regulates the volume and composition of the amniotic fluid.
But the problem is that a large number of prolactin prevents conception. Therefore, elevated prolactin in the planning of pregnancy - is a bad sign.
It inhibits the secretion of pituitary gonadotropins (TG), mainly follicle-stimulating hormone (FSH), resulting in no egg matures in the ovary and ovulation occurs. That is, the menstrual cycle under the influence of a large amount of prolactin become irregular.
Why women can be increased prolactin
The reasons may be many, but obstetricians are divided into two unequal groups. It prolaktinprodutsiruyuschie benign pituitary tumor (prolactinoma), and all other causes. The fact that the prolactinoma - a fairly common tumor, which are always a cause of infertility.
The remaining causes of increased prolactin include severe kidney disease, liver and adrenal glands to decrease their function (diseases that without prolactin is a contraindication to pregnancy), marked reduction of thyroid function (hypothyroidism), polycystic ovaries, estrogenprodutsiruyuschie tumor female reproductive organs and idiopathic hyperprolactinemia (reason for the increase of prolactin is not clear).
You can get pregnant at an elevated prolactin?
Today, the answer is clear: it is possible. But recently a pregnancy at an elevated prolactin was virtually impossible. Today available drugs that stimulate the production of dopamine - the hormone and neurotransmitter, whereby lactotropic hypothalamus suppresses pituitary function.
For drugs in this series (Dofaminomimetiki) are bromocriptine (parlodel), cabergoline (Dostinex), lisuride. All of these drugs can be used in preparation for pregnancy. When hyperprolactinemia their prescribed long courses, while prolactinoma - for life, since these tumors are rare, and today operate only when complications or continued growth. Not all of these drugs can be taken during pregnancy. Pregnant women, if necessary, prescribe bromocriptine.
Dofaminomimetiki normalize prolactin levels, restore the menstrual cycle and fertility. At the same time women recovering throbbing TG secretion pituitary release of luteinizing hormone (LH - it stimulates ovulation
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and supports the second phase of the menstrual cycle) in the middle of the cycle, anovulatory cycles are eliminated, increasing the concentration of estrogen in the body, disappear all the symptoms associated with a lack of female sex hormones and the male excess (overweight, edema, acne
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If elevated prolactin during pregnancy
After pregnancy Dofaminomimetiki in most cases canceled, as during pregnancy has not noted growth figures of prolactin in women with hyperprolactinemia, including tumors of the pituitary gland. But despite the lack of significant growth indicators prolactin, tumor growth can continue. Therefore, some women bromocriptine is prescribed and after pregnancy.
In general, the increased prolactin levels did not affect the course of pregnancy.
To date there is no evidence that prolactin caused miscarriage
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or any complications in childbirth.
Moreover, in pregnant women who received life-saving bromocriptine, increases the risk of death of a child after birth, due to the fact that he has not dealt lungs and he was unable to take the first breath. Such complications may develop due to the fact that light is not enough surfactant - surfactant that coats the inside of the alveoli and prevents them from sticking together. The maturation of surfactant participates prolactin.
Elevated prolactin during pregnancy is not terrible, but it prevents conception.