Diprospan - it means glucocorticosteroid (GCS), which means that it combines high performance and a host of side effects, as the GCS affect all organs and systems of the human body. And this influence is not always positive.

The positive impact on the body diprospana

Diprospan available as a suspension for injection and administered as an intramuscular injection, or directly into the affected organ. It quickly and effectively reduces inflammation, allergic reactions, immunological reactions and inhibits growth of connective tissue. The composition of this drug is such that it begins to act very quickly and this effect persists up to ten days.

Diprospan needed in cases when it is necessary to remove heavy inflammatory process (eg, in the joints), accompanied by severe pain, to remove that other drugs can not be. It is used and in severe allergic diseases, uncontrolled proliferation of connective tissue and a number of other serious diseases in which only the use of corticosteroids may bring relief to the patient.

However, chronic administration of high doses diprospan can have side effects, which also can be very strong.

Side effects diprospana the central nervous system and sensory organs

Diprospan can cause headaches, dizziness, insomnia, seizures, increased pressure vnutrichepernogo (with the possible damage to the optic nerve). Often when it is used, a change of mood - from joy-high (euphoria) to the oppressed (depression), combined with increased anxiety Anxiety - how to distinguish normal from disease?   and irritability Irritability - you try to control my temper . In some cases developed acute psychosis with patient disorientation, delirium Brad - not only crazy   and hallucinations.

Can violated vision due to swelling of the optic disc, sometimes forming cataracts Cataracts - how to solve the problem completely? , Increased intraocular pressure. There may come a sudden loss of vision when administered diprospana in the head or neck. With prolonged use dramatically increases the risk of bacterial, viral and fungal infections of the eye.

Side effects diprospana with the water-salt balance and cardiovascular

Diprospan contributes to the delay in the body of sodium and water excretion of potassium and calcium, which seriously affects the state of the cardiovascular system. The delay in the body fluid causing increased stress on the heart and swelling and insufficient blood levels of potassium and calcium leads to weakness of the heart muscle.

As a result, patients can develop chronic heart failure, persistent increase in blood pressure, cardiac arrhythmias, bradycardia (rare heart rate, sometimes - cardiac arrest). Against the backdrop of slow blood circulation developing thrombosis. In myocardial infarction a risk slow scar formation in necrosis (necrosis) of the myocardial tissue, which may lead to rupture of the myocardium.

Side effects diprospana by metabolic and endocrine

Under the influence of diprospana change all types of metabolism. Increased protein breakdown is a violation of protein metabolism, and the increased accumulation of body fat leads to its deposition in the upper half of the body and increase body weight. Changes carbohydrate metabolism: blood glucose increases and accelerates the process of fat in the liver as glycogen.

Changes in metabolism can not help but reflect on the state of the endocrine system: it may worsen for diabetes develop Cushing's syndrome (a decrease in muscle mass, increase and redistribution of subcutaneous fat, mental disorders, delayed sexual development in children), menstrual irregularities. Against the background of constant suppression of activity of the adrenal cortex occurs atrophy and decreased synthesis of their own SSC.

Side effects diprospana the part of the musculoskeletal system

Under the influence of diprospana atrophy (decrease in volume), muscle weakness. Simultaneously bone loses calcium, which leads to bone fragility and an increased propensity to fracture (osteoporosis) can develop compression (by compression) spinal fractures. There are avascular necrosis (destruction) of the heads of major long bones (femur, humerus). Due to suppression of connective tissue may be torn ligaments and tendons, resulting in instability of the joints.

Children diprospan may cause premature closure of growth zones in the bones and stunted growth.

Other side effects

Often there are erosive and ulcerative lesions of the stomach and intestinal bleeding and perforation of the walls, inflammation of the pancreas.

Disturbed wound healing, thinning skin, increases its sensitivity, tendency to irritation to skin pustular and fungal diseases, the development of stretch marks and cellulite. At the injection site may occur diprostana areas of increased or decreased pigmentation, skin atrophy, sterile abscess and pus.

Sometimes develop allergic reactions such as angioedema or anaphylactic shock.

Diprospan - is an effective drug that gives a lot of side effects.

Galina Romanenko

Dipprospan - a highly effective hormonal drug, which is used mainly in allergic and inflammatory diseases when other means are powerless. But this drug has many side effects, as has a significant impact on the entire body.

How does diprospan

Diprospan means a glucocorticosteroid (GCS). In humans, the SCS produced by the adrenal cortex. They are active against all types of metabolism, particularly carbohydrate and protein metabolism, contribute to the accumulation of glycogen (stored energy) in the liver, increases blood sugar Blood sugar - a very important indicator . Corticosteroids have anti-inflammatory, antiallergic, antishock and antitoxic action, inhibit the operation of certain parts of the immune system. GCS also inhibit the growth of connective tissue, so used in the treatment of connective tissue.

Developing GCS is regulated by the brain and is closely linked with the work of the pituitary gland. Adrenocorticotropic hormone released by the pituitary gland (ACTH), which stimulates the production of corticosteroids by the adrenal cortex. If corticosteroids in the body much the selection of ACTH is suppressed. When long-term administration of drugs, corticosteroids ACTH secretion is suppressed, which can lead to atrophy (decrease in volume) of the adrenal cortex, which stops in the desired SCS allocate to the body volume.

Diprospan has all the properties of corticosteroids, while it consists of two types of salts of the same active ingredient - betamethasone. One of salts (betamethasone disodium phosphate) provides fast action of the drug, and the other (betamethasone dipropionate) - duration (ten days).

But diprospan, like all corticosteroids have many side effects, so it can be used only if strict indications.

To appoint diprospan and to whom it is contraindicated

Diprospan administered by intramuscular, intradermal, intra-articular and periarticular injection in the following diseases and conditions:

• inflammatory, infectious, allergic, and degenerative diseases of the musculoskeletal system - arthritis, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, low back pain;
• systemic connective tissue diseases (collagenosis) - scleroderma, systemic lupus erythematosus, and so on;
• allergic diseases - bronchial asthma, atopic dermatitis, allergic contact dermatitis, and so forth;
• oncology - the suppression of the immune processes leads to the death of tumor cells;
• keloids - Increases in the amount of red welts;
• psoriasis;
• Alopecia areata;
• ulcerative colitis.

Contraindications diprospan at:

• increased sensitivity to the patient's body;
• fungal infections;
• in feeding the baby Breastfeeding - a personal choice   breast;
• vnutrisustvnoe administration is contraindicated in the presence of purulent infection in the joint.

You can not enter diprospan intravenously and subcutaneously. In a number of diseases diprospan administered with caution, under the supervision of laboratory and instrumental investigations. This hypothyroidism (low thyroid function), gastric ulcer and duodenal ulcer, ulcerative colitis, any infection (including herpes, tuberculosis Tuberculosis - a full recovery is not guaranteed , Purulent infection), osteoporosis, chronic renal failure, diabetes mellitus Diabetes - threatening and incurable disease , Hypertension and some other diseases. It is not necessary to apply diprospan and during pregnancy, as it is not proved the absence of negative effects of the drug on the mother and child.

Side effects and overdose

Adverse effects in diprospana very much and they are manifested mainly in long-term use of the drug. There may be side effects:

• from the gastrointestinal tract - nausea, vomiting, bloating, intestinal clicks;
• the central nervous system - insomnia, irritability or depression, combined with increased anxiety, neurotic syndrome;
• by metabolism - brittle bones, weight gain, growth retardation in children, the progression of diabetes, edema;
• the accession of infections due to lower immunity.

Overdose diprospana manifested gain any side effects. The patient may be nausea, vomiting, severe agitation, insomnia. With prolonged use at maximum doses may cause edema, osteoporosis, high blood pressure, atrophy of the adrenal cortex with a sharp decline in its functions.

Diprospan - is effective, but it is not a harmless drug.

Galina Romanenko