Hydrocortisone - side effects of this drug are numerous, however, it is a highly effective drug belonging to the group of glucocorticoid hormones, which is used to reduce inflammation and allergic reactions, swelling and itching.
Adverse effects of hydrocortisone with the endocrine system and metabolism
Hydrocortisone affects various organs and tissues at the cellular level. Long-term use of this drug may cause significant disturbances to the endocrine system.
So, hydrocortisone can inhibit the secretion of pituitary follicle-stimulating hormone (FSH), which leads to disruption of the menstrual cycle and oocyte maturation. It is also possible growth suppression in children, adrenocortical function and through the function of the hypothalamus, which leads to the development of Cushing's syndrome, which is characterized by obesity, lunoobrazmym face increased hairiness, disturbance of intelligence.
Under the action of hydrocortisone
Hydrocortisone - a drug that could save the life of the patient
a decrease in carbohydrate tolerance and develops so-called steroid diabetes
Diabetes - threatening and incurable disease
Violated the water-salt metabolism. Excreted active calcium ions (resulting in the development of osteoporosis) and potassium (developing cardiac arrhythmias, muscle weakness), whereas sodium ions and trapped fluid (edema appear).
Increased protein breakdown leads to decreased immunity and muscle atrophy, and impaired fat metabolism and fluid retention - to an increase in body weight.
Side effects of hydrocortisone in the central nervous system and sensory organs
Side effects of hydrocortisone on the part of the central nervous system are manifested as dizziness, headache, increased intracranial pressure, mental disorders, depressed mood, or groundless, on the contrary, euphoria, excitement, coupled with anxiety, memory loss, seizures.
For part of the view may appear glaucoma
Glaucoma - a perspective possible blindness
(increased intraocular pressure), cataracts
Cataracts - how to solve the problem completely?
, Exophthalmos (protrusion of the eyeball), secondary bacterial eye infections, viral and fungal origin.
Side effects of hydrocortisone on the part of the cardiovascular system
These side effects generally associated with electrolyte metabolism disorders, developing against the background of long-term use of hydrocortisone. The first is cardiac arrhythmia, emerging with a deficiency of potassium, - different types of arrhythmias including bradycardia (slow heart rate), up to a cardiac arrest.
Latency of sodium ions in the body fluids and increases the load on the heart and blood pressure (BP), promotes the development of hypertension and chronic cardiovascular disease. Stagnation of blood in the circulatory system, in turn, contributes to increased thrombosis.
Infringement of blood circulation leads to a deterioration of the patients with myocardial infarction due to the spread of necrosis of the heart muscle. Also slowing the formation of scar tissue at the site of myocardial necrosis that can lead to its tearing.
Side effects of hydrocortisone from other organs and systems
Hydrocortisone irritates the mucosa of the gastrointestinal tract due to stimulation of gastric acid secretion. This can lead to the formation of steroid erosive gastritis and gastric ulcers, gastric bleeding and perforation of the stomach wall. Characteristic symptoms such as nausea, vomiting, increased or decreased appetite, flatulence, hiccups. Sometimes the effects of hydrocortisone developed transient liver function abnormalities, which appear mainly in the form of changes in laboratory parameters.
Under the influence of hydrocortisone may be reduced general and local immunity, leading to frequent colds and secondary bacterial, fungal and viral infections.
On the part of the skin can be delayed wound healing, the appearance of the skin petechiae, thinning of the skin, the appearance of her pigmented and white spots, acne (acne steroid), stretch marks, pustular rash and skin candidiasis. Allergic reactions are also possible, but they are rare.
Local reactions at intramuscular and intravenous injection - a burning sensation, numbness, pain, sensory disturbances (creeping sensation through the body), the development of infection at the injection site necrosis of surrounding tissue, scarring, atrophy of skin and subcutaneous tissue.
When applied topically to the skin may appear redness, swelling, itching, burning, dryness, pustular rash, pigmentation disorders, various types of dermatitis, secondary infection, areas of atrophy, stretch marks.