Immunotherapy herpes infection

Modern methods of treatment of herpes involve compulsory application of immune, since the aggravation of herpes infection always takes place against the background of reduced immunity Immunity - types and characteristics in children in adults . For this purpose, the preparations for nonspecific and specific immunotherapy.

Non-specific immunotherapy can be performed using antibodies, interferons and inducers (stimulants) formation of endogenous (produced by the cells of the patient) of interferon, as well as drugs that stimulate cell-mediated immunity.

The mechanism of action is the substitution immunoglobulin immunotherapy. They contain antibodies to herpes virus, and thus increase the humoral immunity. They also have a detoxifying effect and stimulate cell-mediated immunity.

For the treatment of mild, but often exacerbated herpes infections applied normal human immunoglobulin, wherein the presence is necessary to treat antiherpetic amount of specific antibodies (mainly to HSV-1 which is present in the body of nearly all adults).

For the treatment of severe, including generalized forms of herpes Sandoglobulin used (manufacturer - Sandoz, Switzerland) - human immunoglobulin with a high content of antibodies antiherpetic Antibodies - "soldiers' immunity   Russian or intravenous immunoglobulin.

Interferons

Another means of nonspecific immunotherapy are interferons - proteins produced by human cells during introduction of a virus. In herpesviruses there is no resistance (immunity) to interferon, which makes drugs of this series irreplaceable in the treatment of herpes infections. Interferons also activates the immune cells that contribute to the excretion of pathogens.

Additionally, recombinant interferons are now obtained from biomass by means of genetic engineering. These drugs include viferon and kipferon.

The downside of all interferons (both natural and recombinant) is that they come from outside the body and thus can suppress the production of its own (endogenous) interferon body cells during long-term (within two weeks or more) application. Therefore, the long courses of treatment with interferon cancel, gradually reducing the dose and frequency of application.

This disadvantage is absent in drugs group inducers of endogenous interferon, which stimulate the production of cells in the body's own interferon. Such a mechanism of action have many drugs, both natural and synthetic origin: levamisole, Dibazolum, vitamin B12, pirogenal, prodigiozan and so on.

For the treatment of herpes infections of the eye is particularly effective synthetic interferon inducer Interferon - protects against diseases of the new century?   Poludanum. New in the treatment of herpes - this application Poludan for the treatment of herpes infections with lesions of the skin and mucous membranes. When herpes infection of the skin lesion appoint obkalyvanie poludanom. Poludan also provides general immunostimulatory effect, so is widely used in the complex treatment of herpes infections in the immunocompromised.

Increased use of interferon inducers are manufactured in dosage forms for oral administration, it amiksin, alpizarin, flokazid, arbidol. These drugs most often prescribed to patients with recurrent herpes suffering from frequent colds of viral origin.

To activate cellular immunity of patients with herpes infection with frequent relapses of the disease prescribe such drugs as t-activin, timalin, thymogen, Myelopid and others. In the same stimulating effect it has autohaemotherapy herpes Herpes - a virus creeping   - Treatment of the patient's own blood taken from a vein and then introduced into the muscle.

Specific immunotherapy - is the introduction of tissue herpetic polyvalent killed vaccine, the effect of which is aimed at stimulating the production of antibodies to herpes virus activity of immune cells of blood and removal of the allergic disposition of the body in relation to the herpes virus.

As acne is formed

Acne occurs when hormonal changes, often in adolescence. At the same time under the influence of hormones of the sebaceous glands of the skin grow and begin to produce large amounts of fat with high viscosity. At the same time begins the increased scaling of the surface layers of the skin in the area of ​​the sebaceous glands. Dead cells are mixed with a viscous fat and clog the sebaceous glands - comedones or black this point. The corked sebaceous glands multiply pathogens that cause its inflammation - acne.

Action izotreksina skin

Izotreksin - a gel for external use, which comprises a biologically active ingredient isotretinoin and antibiotic erythromycin Erythromycin - if you are allergic to penicillin . The drug is designed to treat acne. Action izotreksina the skin is determined by its constituent drugs.

Isotretinoin is the active form of retinol (vitamin A). It regulates cell growth surface layers of the skin and their separation into individual species carrying different functions. At the same time too strong isotretinoin inhibits proliferation of epithelial cells of excretory ducts of the sebaceous glands, normalizes the composition of their secretions (sebum for acne changes its chemical composition) and facilitates its elimination. The total amount of sebum secreted by the sebaceous glands, decreases fat does not clog ducts glands (black dots are not formed - comedones) - all this prevents infection and inflammation in the sebaceous glands. Additionally, isotretinoin has anti-inflammatory action and promotes resorption of dead skin cells (keratolytic action).

Erythromycin - a macrolide antibiotic that has a bacteriostatic effect (suspends the reproduction of pathogens) on microorganisms that cause acne. Its mechanism of action is based on inhibition of the formation of the protein in the membranes of bacteria.

Together, both components izotreksina one hand inhibit the formation of comedones and plugging of the sebaceous glands, and on the other - to prevent the proliferation of the sebaceous glands infection.

The blood is sucked izotreksin slightly, excreted in the feces and urine.

Indications for use and rules for its application to the skin

Izotreksin used to treat acne Acne treatment: how to get rid of blackheads   mild or moderate severity.

Izotreksin gel used externally by applying on the affected acne Acne: facial trouble   a thin layer of skin twice a day. Before applying the gel on your skin clean by washing makeup. The effect of the treatment does not appear immediately, sometimes it takes about two months of continuous use of the gel.

Contraindications and side effects

Contraindications for treatment izotreksinom are children under the age of 12 years, pregnancy, breast-feeding Breast-feeding: feed - and no nails!   child and individual intolerance of components.

Side effects of the drug can occur in a variety of skin reactions: minor tingling, burning, and irritation at the application of the gel, the appearance of redness and peeling of the skin, increased sensitivity to light. When any of these effects, treatment should be interrupted and resumed only after their complete disappearance. If the side effects do not disappear or be resumed again after re-treatment, treatment should be discontinued. Izotreksina overdose have been identified.

When using izotreksina advised to avoid contact with mucous membranes of the mouth, nose and eyes, and from the wound surface. On the sensitive skin of the neck and around the eye gel should be applied with caution. During the course of treatment izotreksinom necessary to limit exposure to the sun, as it may cause increased sensitivity to sunlight.

When using izotreksina not advised to use other drugs having the exfoliating dead cells and dissolving properties of the skin, including containing vitamin A.

Action izotreksina weakened while the application (inside or outside) of antibiotics of the tetracycline group and also when applied topically glucocorticoid hormones.

Izotreksin - effective acne gel.

Galina Romanenko