Thyroxine - is the main thyroid hormone
Thyroid hormones: mechanism of action and physiological effects
Which actively affects all types of metabolism and function of all organs and systems. As medicament applied today synthetic analog of a natural thyroxine - levothyroxine or L-thyroxine.
How does thyroxine
Thyroxine (T4) - is one of two iodinated thyroid hormones. The second hormone is triiodothyronine (T3). Thyroxine has low biological activity, but in the tissues by the enzyme is partially converted to a more biologically active triiodothyronine. Iodine-containing hormones actively influence the metabolism and function of all organs.
After conversion of T4 to T3 by the liver and kidneys, and entry to the cell body has a regulating effect on the growth and development of tissues, and metabolism
Improves metabolism and losing weight without dieting
.
The medicine comes in the form of thyroxine is a synthetic analogue of the natural hormone - levothyroxine (L-thyroxine).
In small doses, a L-thyroxine has an anabolic effect, ie, it promotes the synthesis of proteins that accelerate the formation and renewal of the structural parts of cell, tissue and muscle structures. In high doses, L-thyroxine stimulates the growth and development of tissues, increasing their requirement for oxygen, it stimulates all types of metabolism (protein, fat, carbohydrate) enhances the function of the cardiovascular and central nervous systems. In high doses, a L-thyroxine inhibits the production of hormones of the hypothalamus (thyrotropin-releasing hormone) and pituitary glands (thyroid-stimulating hormone - TSH).
The therapeutic effect is no earlier than one week after the start of treatment. After the cancellation of L-thyroxine, he kept the same throughout the week.
Which diseases are taking a L-thyroxine
The main indication for the reception of L-thyroxine is the reduction of the thyroid gland - hypothyroidism. In this case, the drug is often necessary to take a life.
Another disease in which often prescribe a L-thyroxine is euthyroid goiter - a disease in which increases the amount of thyroid tissue (formed goiter) with normal thyroid hormones in the blood.
L-thyroxine often administered as replacement therapy for example after complete or partial removal of the thyroid gland (e.g., thyroid cancer).
In diffuse toxic goiter resistant to suppress thyroid function a L-thyroxine is prescribed after reaching normal thyroid function tireostatikami.
Take a L-thyroxine once a day, in the morning half an hour before meals individually selected dosage.
Contraindications
Contraindications for the purpose L- thyroxine are: increased sensitivity of the patient to the drug, untreated hyperthyroidism (when the blood contains large amounts of thyroid hormone), myocardial infarction, acute myocarditis (inflammation of the heart muscle), untreated adrenal insufficiency, hereditary intolerance of simple carbohydrates ( galactose), lack of the enzyme lactase to digest the lactose malabsorption or simple sugars - glucose and lactose.
With care a L-thyroxine is used in coronary heart disease, persistent increase in blood pressure (cardiac arrhythmias, diabetes, severe long flowing hypothyroidism, malabsorption syndrome (malabsorption of nutrients in the small intestine).
During pregnancy intake of L-thyroxine appointed on the reduction or complete loss of function of the thyroid gland, should continue, but at a higher dose, because during pregnancy, increased levels of thyroxine-binding proteins in the blood.
During breastfeeding also should be designated before a L-thyroxine to cause any disturbances in the child he can not.
Side effects of L-thyroxine in its correct application in the dosage prescribed by the doctor is not shown.
Is it possible to overdose of L-thyroxine?
In case of overdose of L-thyroxine showing signs of increasing thyroid function: heart palpitations, irregular heartbeat, heart pain
Pain in the heart - always consult a doctor
, Anxiety, tearfulness, irritability
Irritability - you try to control my temper
, Trembling of the limbs and sometimes the whole body, insomnia, sweating, increased appetite, diarrhea, weight loss.
When these symptoms should stop taking the drug and seek medical advice. In accordance with the state of the patient's physician may reduce the dosage of L-thyroxine, completely cancel it for a few days or designate drugs for suppressing side effects.
Thyroxine - a thyroid hormone, has an active effect on all organs and body systems. Therefore prescriber composed of synthetic analogues of thyroxine may be a doctor.
Galina Romanenko