Geptral - it hepatoprotector (drug, a beneficial effect on the liver function) with antidepressant activity. It is widely used both in various diseases of the liver to prevent their progression and in psychiatry, where used to display the status of the patient's depression
Depression - a little more than a bad mood
Features geptrala injection
Geptral injection produced no ampoules and vials, which is 400 mg of active principle geptrala (ademetionine) as a lyophilized powder. In addition, the product contains 5 ml ampoule with a solvent. Enter solution geptrala intramuscularly or intravenously (slowly).
Manufacturer geptrala pharmaceutical company Abbott (USA) has developed detailed instructions for use of the drug, but it always assigns the doctor, he also picked individually daily dosage and duration of treatment.
Geptral injection actively influences the condition of the liver cells (hepatocytes). Basically it regulates deducing therefrom the bile acids and other substances are removed from the body in the bile. Bile acids are removed from the cells through the membrane by means of special transport systems.
If you violate state and hepatocyte membrane under the action of toxins of various origins and disrupted transport systems. This leads to accumulation within the hepatocyte bile acids that destroy them, and then place hepatocytes grows connective tissue. Geptral suspend this process, it restores normal cell membranes, transport through her bile acids. Damaged cells under the influence of geptrala restored, and the process of cell proliferation of the connective tissue is suppressed, which contributes to the stabilization of the liver with cirrhosis of any origin.
Similarly Heptral protects liver cells from the action of any toxins is formed within the body (eg, free radicals), and received from the outside (alcohol, drugs, hepatotoxic drugs).
It was also established that the active substance geptrala ademetionine can penetrate the blood-brain barrier, that is exposed from the blood into the brain tissue. Here he is actively involved in the biochemical processes and restores normal neurons. This improves the conductivity of nerve impulses, activates the activity of the entire central nervous system and the patient comes out of the doldrums.
Which diseases Heptral administered by injection
The main indications for the purpose geptrala by injection are acute and chronic diseases of the liver and biliary tract. Geptral help when exposed to any damaging liver tissue factor - viruses and toxins, bile acids, free radicals, toxic agents (alcohol, drugs, etc.). In addition, Heptral prescribed for stagnation of bile in the biliary tract - in the bile ducts and gall bladder, but in the absence of this system rocks.
Geptral often prescribed for depression and, especially, in the case when patients revealed resistance (immunity) to other antidepressants such as amitriptyline.
As prescribed Heptral
In order that the treatment was effective, geptral first administered as intramuscular or intravenous injection, which are then replaced with the tablets. Powder for injection in vials diluted enclosed solvent immediately before injection, the medication remainder can not be stored. Introduction of the solution into the vein to be very slow. Geptral not be diluted with alkaline solutions or solutions, which include calcium.
The manufacturer recommends to appoint Heptral rate of 5-12 mg per kg of body weight of the patient per day.
This is an average of 400-800 mg exceed this dose is not recommended. The course of treatment for injection in liver disease is two weeks, depression - three weeks. Thereafter, it is recommended to go to the reception geptrala inside a pill of 800 - 1200 mg per day. Duration of treatment is determined by a doctor, but it can not be short-lived, on average, it is recommended to take Heptral from two weeks to two months.
Side effects and contraindications
Adverse effects in geptrala injecting slightly more than the tableted dosage form:
- the part of the digestive system - dry mouth, nausea, vomiting, abdominal pain
Abdominal pain: Types and Symptoms
Diarrhea; sometimes develop inflammation of the esophagus, abdominal swelling, bleeding from the stomach or intestines, liver colic;
- on the part of the brain - insomnia, dizziness, headache, sensory disturbances, confusion;
- on the part of the musculoskeletal system - pain in muscles and joints, cramps;
- on the part of the urinary tract - the development of infectious and inflammatory processes;
- of the skin - increased sweating, itching, skin rash;
- Local reactions - sometimes at the injection site irritation and even death (necrosis) of the skin, inflammation of the veins (phlebitis);
- sometimes on background geptrala injections may rise high fever, weakness, swelling, allergic reactions.
Geptral - protection and support to the liver and not only
in case of hypersensitivity to it of the patient, in the first and second trimesters of pregnancy, breast-
Breastfeeding - a personal choice
chest and under the age of 18 years.