Brown isolation in the middle of the cycle may be associated with ovulation Ovulation - How to determine as accurately as possible? That is a variant of the norm. But if the separation lasts longer than two days, it's likely this is due to hormonal disorders or chronic infectious-inflammatory processes of female genital mutilation.

Brown discharge in mid-month as a variant of the norm

Slight spotting brown in the middle of the menstrual cycle for a period of 1-2 days may be one of the manifestations of ovulation. Ovulation - a way out egg from the ovary. The egg in the ovary is enclosed in a special bubble - the follicle. When the egg matures, the follicle bursts, the egg leaves the ovary falls first to abdominal cavity and then into the fallopian tube, where for two days after ovulation can be fertilized by sperm.

Before ovulation may increase the secretion, vaginal secretions have a clear view of mucus. If after ovulation them mixed with blood, it turns brown mucus. These brief slimy brown discharge Brown allocation - what do they say?   mid-cycle are also the norm.

Dark brown allocation in mid-cycle when taking hormonal contraceptives

In the first three months of combined oral contraceptives (COCs) in the middle of the month may appear different spotting, including dark brown. Later in the regular COC these effects disappear.

Perhaps the appearance of dark brown precipitates in the middle of the cycle with irregular COC. In this case the contraceptive effectiveness decreases.

Brown allocation midcycle at various gynecological diseases

Call the appearance of brown discharge in the middle of the cycle may be infectious and chronic inflammatory diseases of internal genital organs - the uterus and its appendages (endometritis and adnexitis). Long-term inflammation of the uterus leads to inferiority its inner layer (endometrium) and premature partial exclusion. In inflammatory processes in the uterus in the middle of the menstrual cycle spotting can appear small, their color has different shades of brown.

Equally often the cause of brown discharge in the middle of the menstrual cycle are diseases such as endometrial hyperplasia Hyperplasia endometrial cancer - requires timely detection and treatment   and endometriosis. And in fact, in both cases, the body produces an excess of estrogen. Under the influence of the endometrium considerably increases in volume. And since then there is a lack of progesterone in the second half of the menstrual cycle does not occur the full maturation of the endometrium and it can be separated from the uterine wall in small areas, which causes neobilnye prolonged bleeding or spotting.

Brown discharge during pregnancy

At the beginning of pregnancy with inadequate secretion of progesterone by the corpus luteum possible miscarriage as progesterone Progesterone - norm and pathology   It inhibits the contraction of smooth muscle of the uterus. In this case, the miscarriage may begin with the appearance of brown spotting. Then there are severe abdominal pain, bleeding and removal of the ovum.

Brown discharge can also be a sign of an ectopic pregnancy, where the fertilized egg attaches and is not developing in the uterus, and elsewhere, most often in the fallopian tube. Small brown spotting can say that the wall of the fallopian tube scarred. When it breaks, it begins a strong internal bleeding. There may also be discharge neobilnye brown vaginal discharge.

Miscarriage and premature labor may begin with spotting. At this stage, abortion can be stopped without waiting for severe bleeding. A woman requires emergency medical care.

Placental abruption - a condition that threatens the life of the mother and child, as the placenta is connected tightly to the wall of the uterus, which is shared blood vessels. Therefore, even a small spotting is very dangerous - it can turn into a full-fledged bleeding. In most cases, the appearance of spotting in the middle of a woman's pregnancy is hospitalized.

Brown discharge in mid-month can be both healthy women and those suffering from a variety of gynecological diseases. So it makes sense to consult a gynecologist.

Galina Romanenko

Diflucan - a subclass of antifungal triazole derivatives. The drug is available in tablet form for oral administration, a powder for suspension and intravenous solution. The active ingredient of Diflucan is Fluconazole. Tablets containing 50, 100, 150 or 200 micrograms flukanozala and the following inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate, povidone, croscarmellose sodium and magnesium stearate.

Formulation

The powder slurry composition includes 350 or 1400 micrograms of fluconazole, and sucrose, sodium citrate dihydrate, citric anhydride, sodium benzoate, titanium dioxide, colloidal silica, xanthan gum and flavor.

In one milliliter of solution for injection Diflucan contains 2 micrograms of fluconazole Fluconazole - used with caution   and 9 micrograms of sodium chloride or dextrose 56 micrograms. pH ranges from 4.0 to 8.0 in a solution of sodium chloride in the solution to 3.5-6.5 dextrose.

How to take Diflucan

Take your medication exactly as directed by your doctor. The dose depends on the disease: for the treatment of vaginal infections is one tablet is enough to treat others need a long course of treatment. Tell your doctor if in the course of treatment you will not notice the improvements.

Wash down pill Diflucan full glass of water.

Capacity with the oral suspension must be shaken before each use.

Diflucan should be taken for as long as recommended by the doctor. Otherwise there is a risk of re-infection, pathogens which can be resistant to the drug. Diflucan Store at room temperature, away from heat and moisture. The solution can be stored in the refrigerator, but do not let it freeze.

Side effects

Should be paid to emergency medical help if shortly after receiving Diflucan patient notices have the following symptoms of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

When side effects such as nausea, abdominal pain, slight fever, loss of appetite, dark urine, skin rash, itching, unusual weakness and causeless, you need to call your doctor.

In addition, there are Diflucan side effects such as headache, diarrhea, and / or dizziness. They tend to pass quickly and do not require medical intervention.

Before you start taking Diflucan, tell your doctor if you once had an allergic reaction to any antifungal drugs; it is also recommended to inform him about any other allergies, not only for medicines. If you have disorders of the liver, kidneys and heart, be sure to tell your doctor.

Diflucan is indicated for the treatment of the following diseases

Vaginal candidiasis (vaginal fungal infection caused by yeast of the genus Candida)

• Candidiasis oropharynx and esophagus. Recent studies have also confirmed the effectiveness of Diflucan as a means of treatment of candidiasis of the urinary tract, peritonitis, systemic candidiasis, including candidemia, disseminated candidiasis and pneumonia
• Cryptococcal meningitis
• Diflucan is sometimes prescribed for the prevention of candidiasis in patients undergoing bone marrow transplants, as well as those who pass cytotoxic chemotherapy Chemotherapy - it always falls the hair?   and / or radiation therapy

pay attention

Most people tolerate receiving Diflucan. However, some patients, particularly those with severe major diseases such as AIDS and cancer, after administration of the drug can occur hematological disorders and renal function. Data from clinical studies on this subject is not entirely accurate.

Diflucan in the form of tablets or suspension can be taken with a meal or between meals at any time of the day. Intravenous administration of the drug is also permitted at any time. Diflucan cope with the infection in a few days, the symptoms usually begin to subside within days. Completely they will be 3-4 days. If symptoms persist after a few days after you start taking Diflucan should talk to your doctor.

If you accidentally take more dose of Diflucan than you were prescribed, and consult a doctor. If after exceeding the dose you have any severe symptoms of an allergic reaction to medication, call an ambulance.

Drug Interactions

Be sure to tell your doctor if you are taking any of the following medicines as they may engage in undesirable interactions with components of Diflucan:

• Blood-thinning drugs such as warfarin Warfarin - indirect anticoagulants ;
• Alfentanil (Alfenta), fentanyl);
• Clopidogrel (Plavix);
• Cyclophosphamide (Cytoxan, Neosar);
• Cyclosporine;
• Methadone;
• Pimozide (Orap);
• Prednisolone;
• Saquinavir and zidovudine (Retrovir, Trizivir);
• Sirolimus (Rapamune) or tacrolimus (Prograf);
• theophylline (Elixophyllin, Uniphyl, and others);
• Voriconazole (Vfend);
• Antidepressants, such as amitriptyline or nortriptyline;
• Antineoplastic drugs such as vinorelbine, vincristine, or vinblastine;
• Drugs that lower cholesterol, such as atorvastatin, fluvastatin (Lescol), lovastatin, pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor, Simcor, Vytorin);
• Preparations for the treatment of heart disease and blood pressure normalization - amlodipine, felodipine, isradipine (Dynacirc), losartan (Cozaar, Hyzaar), or nifedipine;
• NSAIDs (nonsteroidal anti-inflammatory drugs) such as ibuprofen, naproxen, celecoxib, diclofenac Diclofenac - relieve inflammation and pain , Indomethacin, meloxicam, and the like;
• Antidiabetic drugs - glipizide (Glucotrol), glyburide, tolbutamide (Orinase), tolazamide (Tolinase), chlorpropamide, and so on;
• Rifabutin or rifampicin;
• Sedatives, such as diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), midazolam (Versed), or triazolam;
• Anticonvulsants - Carbamazepine, phenytoin and valproic acid.