The results of recent research suggest that the diagnosis of the type of endometrial hyperplasia is necessary, first of all, to identify the following: whether simple or complex hyperplasia, as well as whether there are abnormal cells in the endometrium (in this case speak of atypia).

Types of endometrial hyperplasia

Atypia may be present in the simple and complex hyperplasia, so the total is divided into four main types of violations.

With a simple hyperplasia without atypia observed cell proliferation, but the basic structure of the endometrium remained relatively unchanged. This species is considered the most secure hyperplasia. Sometimes it is also called glandular-cystic hyperplasia.

Patients with complex hyperplasia Hyperplasia - do not be afraid   without atypia individual endometrial cancer may be increased, but, as with simple hyperplasia without atypia, the internal structure of cells remains normal. However, in case of violation of this type of cell proliferation is already leading to a change in the structure of the endometrium. Location and shape of the gland change and under a microscope the entire structure is less uniform. This species is also called adenomatous hyperplasia endometrial hyperplasia.

For any endometrial hyperplasia without atypia likelihood that it will grow into a violation of endometrial cancer is about 1-4% .  In itself, this statistic does not say almost nothing, but it takes a certain value, if noted that the likelihood of cancer of the endometrium in the average woman has no serious health problems, is about 3% .  Therefore, usually endometrial hyperplasia without atypia is not considered precancerous neoplasm .  In most cases, hyperplasia responds well to progestin therapy - under the influence of hormones the endometrium (together with problematic neoplasm) is rejected, both during normal menstruation .  Hyperplasia without atypia are the most common, and can be cured easily .  In addition, if one of those species hyperplasia began to develop until menopause, after its occurrence problem is likely to completely disappear due to hormonal changes .

What does the presence of atypical cells? When atypia cells themselves are changing their structure becomes abnormal. These changes are similar to those that occur in the cervical dysplasia Dysplasia - what is it? . Although these cells are not cancerous, there is an increased likelihood that they will be once established. For this reason, atypical endometrial hyperplasia Hyperplasia endometrial cancer - requires timely detection and treatment   refers to precancerous diseases.

Since atypia is also divided into simple and complex, the following types of endometrial hyperplasia is simple atypical hyperplasia. It is kind of hyperplasia rarer above; often at the same violation is sufficiently effective progestin therapy. The possibility that a simple atypical hyperplasia develop into cancer of the endometrium, sostavlyaete 8%.

Complex atypical hyperplasia endometrial cancers becomes approximately 25-30% of cases. Therefore, for the treatment of this disorder, doctors usually recommend a hysterectomy - surgical removal of the uterus Hysterectomy (removal of the uterus) - a terrible need .

Advice

Women who want to preserve the uterus and possibly the ability to have children in the future, you should know that even in this type of hyperplasia are several sub-types - from mild to severe forms of the disease. Mild form of complex atypical hyperplasia often amenable to progestin therapy. However, the more severe form of the disease, the less likely it is that hormone therapy will be effective. According to one study, only 20% of cases of severe complex atypical hyperplasia treatable progestin, and often (in 25-45% of cases) after a hysterectomy in patients with this disorder discovered previously undiagnosed cancer of the endometrium.

Of course, the decision about the choice in favor of a method of treatment is taken separately in each case; should take into account all possible risks and benefits associated with all methods. Be sure to take into account the desire of the patient, its age and general health. For example, for women in the postmenopausal age, taking medications for hormone replacement therapy, hysterectomy may be the preferred method of treatment, as they have in the complex atypical hyperplasia increased risk of endometrial cancer.

Even if hyperplasia still lead to the development of cancer, all may not be as scary as it sounds. The fact that endometrial cancer grows and spreads slowly, and its features are almost always appear very early - usually a non-menstrual bleeding (they are a major symptom hyperplasia). If a woman regularly undergo a medical examination, and is closely monitoring the health, noting any change in his status, complex atypical hyperplasia and endometrial cancer will certainly be identified long before they become life-threatening.

Hexicon is antiseptic drug, active mainly against Gram-negative and Gram-positive bacteria, protozoa (Trichomonas) and certain viruses (herpes simplex virus), causing a variety of diseases, sexually transmitted diseases. Effective from and bacterial vaginosis Bacterial vaginosis - sex is not recommended .

Unpleasant fungus

Thrush genitals, are known to cause yeast fungi genus Candida. Officially, (according to the instructions, the manufacturer's) believed that Hexicon not active against fungi, ie fungi that are resistant to hexicon. Nevertheless, gynecologists in the practical application came to the conclusion that Hexicon well helps with mixed bacterial and Candida infections of the vagina.

The number of infectious and inflammatory diseases of the female genital organs, including candidiasis and bacterial and Candida character recently increased significantly (some researchers believe that it accounts for almost half of all infectious and inflammatory diseases of the vagina), at the same time there is a constant decrease in sensitivity to various kinds of antiseptics, inhibits the development of a mixed microflora. Such a significant spread of fungal diseases of female genital mutilation is often dependent on the adverse effects of the environment on the human body, changes in the environment, frequent and sometimes uncontrolled use of antibiotics, which leads to a decrease in the body's defenses. As is known, fungi Candida genus which cause disease while reducing immunity.

Research

In this regard it has recently been a number of studies on the effects on hexicon candidiasis and a mixed bacterial and Candida infections. Such studies, in particular, have been conducted at the Department of Microbiology of the Perm State Medical Academy. The study involved patients divided into two groups. In the first group were patients with vaginal candidiasis (ie thrush), and the second - with a mixed bacterial and Candida infections. At the same time for the purity of the experiment of it excluded all patients with any acute or chronic diseases of the pelvic organs, infections, sexually transmitted diseases (included patients with only a nonspecific bacterial infection - staph, strep, caused by E. coli, etc.), and other diseases, requiring the use of systemic antibiotics.

All patients first and second groups impose specific to yeast infections and mixed complaint. The diagnosis was confirmed also during a pelvic exam Gynecological examination: an important component of women's health   and laboratory (microscopic and microbiological) research.

Patients in both groups were appointed by vaginal suppositories Vaginal suppositories - for contraception and treatment of inflammation   Hexicon one suppository twice daily for 10 days. In addition, restorative drugs prescribed to help restore immunity (vitamin-mineral complexes, tincture of Siberian Ginseng, and so on).

The efficacy of treatment was assessed on the 17th and 30th days of the study on the presence or absence of complaints of patients, of the vaginal mucosa, a change in the character of discharge and laboratory data (microscopic and microbiological studies) vaginal contents.

On the 17th day of the study in the first group after treatment 81% of patients 6 not complain, 18, 4% complained of some discomfort in the vagina. When viewed from the external genitalia were without pathological changes. Laboratory studies have found a single fungal spores, which corresponded kandidonositelstvo, that is the norm (Candida species always live in the vagina). In the second group 92% of patients after treatment did not show any complaints, smear microscopy fungal spores and mycelia threads are not identified, the number of leukocytes was normal.

On the 30th day of treatment, 82% of women of the first group did not show any complaints, laboratory studies of vaginal discharge Vaginal discharge   It showed no signs of vaginal candidiasis. The remaining patients continued to experience discomfort in the vaginal area and they were abundant milky discharge. In laboratory studies, they had found a large number of spores of fungi of the genus Candida and pseudomycelium.

In 92% of patients of the second group were no complaints and control laboratory tests were negative. The remaining patients continued to complain of discomfort in the vulva and vaginal secretions abundant. In laboratory studies, they had found a moderate amount of white blood cells, yeast cells and fungal spores.

Thus, studies were established efficacy hexicon thrush 82%, and the mixed bacterial-candidal infection in 92%, which is allowed to recommend use of suppositories Hexicon the treatment of candidal pure and mixed infections in women.

  Galina Romanenko