Prednisolone and alcohol - are substances that have a very intense effect on all organs and body systems, including metabolism
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. The effect of these substances on the various organs of the same times, and sometimes just the opposite, so to use alcohol during treatment with prednisolone dangerous.
Action prednisone and alcohol on the cardiovascular system
Prednisolone and rapidly activates the stress hormone
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adrenaline. The action of adrenaline in the body due to the ancient instinct of self-preservation, which can be briefly described as "fight or flight". When danger threatens human adrenaline causes the body on full alert to ensure that he could fight back or run away. First of all, instantly narrowed blood vessels, increased blood pressure (BP), heart rate increases and the number of respiratory movements. All this allows us to activate all the other organs and systems of the human body.
Under the effect of prednisolone body loses potassium and calcium, and sodium and fluid accumulates. Potassium deficiency causes problems from the cardiac muscle - it loses its contractility, leading to stagnation of the blood and tendency to form blood clots.
Alcohol also has a significant effect on the cardiovascular system. Immediately after receiving the blood vessels dilate and blood pressure falls, but then comes the persistent narrowing of the blood vessels and raising blood pressure. When receiving alcohol body loses fluid, and with it the macro- and trace elements, including sodium, potassium and calcium.
Loss of potassium while taking prednisone and alcohol can seriously affect the heart activity and concentration and lead to a stagnation of blood clots and blockage of vital blood vessels.
The body of each person is different and it is impossible to predict how the cardiovascular system, even a healthy person will react to the impact of both prednisolone and alcohol. But healthy people usually do not take prednisone, and the impact of this combination on patients with the more difficult to predict.
Action prednisone and alcohol on the central nervous system
Prednisone can have significant side effects on the central nervous system (CNS), as it increases the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. In its application, especially in high doses, may cause headaches, dizziness, increased intracranial pressure, anxiety, anxiety
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, Insomnia, seizure. Sometimes patients during treatment with prednisolone disturbed orientation, mood changes (depression or appear, on the contrary, euphoria). In rare cases, long-term use at high doses develop full-fledged psychosis with hallucinations.
Alcohol also has a significant effect on the central nervous system, it suppresses it braking. This leads to the stimulation in the initial stages of intoxication, that is actually alcohol and prednisone will act in one direction, which may increase the risk of psychosis and other severe complications of CNS.
Especially hard prednisolone combination with alcohol can affect the condition of patients with chronic alcoholism, which the next day after drinking alcohol withdrawal syndrome develops, the outcome of which may be delirium tremens or delirium tremens.
Action prednisone and alcohol on the digestive organs
Prednisolone suppresses the production of biologically active substances of prostaglandins, which are involved in allergic and inflammatory reactions. But prostaglandins also protect the gastric mucosa from any harmful effects, therefore deprives prednisolone gastrointestinal protection. Simultaneously prednisolone it stimulates excessive secretion of hydrochloric acid and pepsin in the stomach, which leads to the formation of steroid ulcers in the gastrointestinal tract.
Prednisolone may also have a negative effect on the liver, as it was in this organ is its decomposition into metabolic products (metabolites) can occur as a result of transient liver function abnormalities.
Alcohol can irritate the stomach lining and stimulate gastric secretion, which, of course, accelerate the formation of steroid ulcerative lesions of the gastrointestinal tract.
It is well known direct toxic effect of alcohol on the liver cells, so combine it with alcohol intake is dangerous, and in this respect: the reaction of the liver to such a combination depends on the individual, including the functions of its enzymes, features which are dependent on heredity.
Alcohol should not be combined with medication, but even more so with the reception of highly effective drugs such as prednisone
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.
Galina Romanenko