When using any drugs with alcohol at least reduces their effectiveness. But many people want to know whether it would be some sort of special, very strong reaction with alcohol during treatment with antibiotics. And this reaction is, however, not always.

Why not combine with alcohol intake amoksiklava

Alcohol - a toxic substance, which can actively intervene in the metabolic processes that occur in cells, especially in the liver and brain, to which it has a direct toxic effect.

Amoxiclav penetrates the tissue and is competing with alcohol "for a place under the sun." This is not the fact that he will win and replace alcohol. And if that does not happen, the treatment Amoksiklava will be hit, the force of which will depend on the strength of alcoholic drinks and the duration of its use. Of course, if it is a glass of dry wine, it's okay, it is not likely to happen. But spirits can really hurt.

Furthermore, amoksiklav Amoxiclav - an effective tool against infections   decomposed in the liver and may cause hepatotoxicity (liver cells are destroyed) action. The action is slightly and rarely cause even transient liver function abnormalities, but who knows, perhaps a combination of small effects from the direct toxic effect on the liver cells of alcohol would be "the last straw" which will launch the mechanism of liver damage.

But the most unpleasant that in recent years, frequent cases of antabusopodobnyh reactions while taking alcohol and certain antibiotics.

What is the reaction of antabusopodobnaya

Antabuse (teturam, disulfiram) - a substance that is used in industry to produce rubber. Incidentally, it was observed that the workers employed in this production, receiving liquor is avoided due to their appearance thereafter discomfort. So disulfiram has been applied for the treatment of patients with chronic alcoholism.

The mechanism of action of disulfiram is simple: it destroys the body's enzyme (aldehyde dehydrogenase), which normally inactivates the toxic breakdown product of alcohol (acetaldehyde). That toxic acetaldehyde and causes the most unpleasant (and sometimes life-threatening) experience. There are other enzymes which decompose acetaldehyde, but disulfiram and destroys them. Such a reaction is called Antabuse-alcohol.

Today found that this reaction may cause other substances that block the acetaldehyde decomposition - is metronidazole Metronidazole - what is it?   (Trichopolum) furozolidon and some antibiotics. The reaction occurs at the same time, called antabusopodobnoy or disulfiramopodobnyh.

How is the reaction antabusopodobnaya

Upon receipt of any substance capable of inactivating aldehyde dehydrogenase, together with alcohol, the patient feels a sudden rush of blood to the head and upper body, a feeling of tightness in the chest, shortness of breath, tinnitus, sudden drop in blood pressure Blood pressure - dangerous if his swing? , Palpitation. There are also nausea, vomiting, anxiety and a feeling of "impending death". Duration and severity of this reaction depends on the dose of the drug and the amount of alcohol taken. With a very strong antabusopodobnyh reactions can develop collapse and loss of consciousness.

Especially dangerous antabusopodobnaya response for patients suffering from diseases of the cardiovascular system, pulmonary failure, impaired hepatic and renal function.

Can there be antabusopodobnaya reaction when taking alcohol during treatment Amoksiklava

Today, great importance is attached to the hereditary characteristics of the human body, especially of its enzyme system. The absence of a particular enzyme or of its insufficient formation gives rise to various inherited diseases.

But there enzymes to insufficient or excessive content of which can be found in the body only after inspection. How to behave these enzymes when ingested combination of these or other substances with alcohol is difficult to predict.

Regarding amoxiclav, one of its components is amoxicillin - antibiotic Antibiotics - whether they will help you in the foreseeable future?   penicillin. All antibiotics penicillin called beta-lactam, because their chemical structure is the so-called beta-lactam ring. Some types of bacteria produce beta-lactamase enzymes which destroy the ring, so penicillins they do not operate. To increase the effectiveness of penicillins combined with other substances that block the action of beta-lactamase. In this role Amoksiklava clavulanic acid.

The closest "relatives" penicillin antibiotics are cephalosporins, which are also contained in the structure of beta-lactam ring. Today, it is well established that when taking alcohol during treatment with cephalosporins antabusopodobnaya reaction occurs. So is it worth the risk?

Galina Romanenko

The dosage regimen and the duration of application amoksiklava set individually depending on the severity and localization of the infection susceptibility, as well as the age, weight and health of the patient, in particular its state of kidneys. When receiving amoksiklava need to exactly follow the instructions of the doctor, as well as instructions on the packaging of the drug.

How to calculate the dose

Amoxiclav usually taken three times a day (every eight hours), but the exact dosage prescribed by the doctor. It is necessary to evenly distribute amoksiklava reception throughout the day. Children under the age of twelve amoxiclav administered as a suspension, syrup or drops for the oral administration. A single dose is determined depending on age: children up to three months - 30 mg / kg / day in two divided doses; three months or older - infections mild - 25 mg / kg / day in 2 divided doses, or 20 mg / kg / day in 3 divided doses, severe infections - 45 mg / kg / day in 2 divided doses, or 40 mg / kg / day in 3 divided doses.

The maximum daily dose of amoxicillin for adults and children over 12 years is 6 grams, for children up to 12 years - 45 mg per 1 kg of body weight. The maximum daily dose of clavulanic acid for adults and children over 12 years - 600 mg for children up to 12 years - 10 mg per kilogram of body weight.

Medical forms

With difficulty swallowing in adults recommended suspension. When preparing the suspension, syrup and drops as the solvent, use water.

To prevent postoperative infection during operations lasting less than one hour, during induction of anesthesia is administered at a dose of 1 g intravenous. At longer operation - 1g every 6 hours during the day. With the high risk of infection, administration may be continued for several days.

The tablets should be taken with a little water. Vials with powder for suspension should shake before use. When cooking, use only suspension dosing spoon that is included with the drug, not a regular table or a teaspoon.

It is necessary to complete a full course of treatment Amoksiklava even after signs of improvement. Interrupting treatment can lead to the development of immunity to bacteria amoksiklav.

Cautions

In exchange treatment is necessary to control the state functions of blood, liver and kidneys.

• If you forget to take amoksiklav Amoxiclav - an effective tool against infections   at a specified time, take the drug at the first opportunity. Amoksiklava next dose should be taken in four hours. Do not take two doses in one to two hours.
• If there is no improvement after treatment Amoksiklava should consult a doctor.
• Perhaps the development of superinfection due to growth insensitive to it microflora, which requires a corresponding change in antibiotic therapy.
• Amoxiclav can give false-positive results in the determination of glucose Glucose: The energy source   in urine. In this case, use glyukozoksidantny method of determining the concentration of glucose in the urine.
• After dilution amoxiclav suspension should be kept not more than 7 days at refrigerator temperature (2 - 8 ° C), but not frozen.
• In patients with increased sensitivity to penicillin, may be cross-allergic reaction with cephalosporin antibiotics.
• There were cases of necrotizing colitis in infants, pregnant women with premature rupture of membranes.

Since tablets contain the same amount of clavulanic acid (125 mg), should be considered that two tablets of 250 mg (as amoxicillin) are not equivalent to one tablet of 500 mg (as amoxicillin).

With intravenous administration of large doses of amoksiklava should increase fluid intake to reduce the risk of crystals in the urine. If the patient is hospitalized, additional liquid can be administered through a drip.

Broad-spectrum antibiotics can cause inflammation of the intestines (colitis). Therefore, the appearance of diarrhea after taking amoksiklava, especially containing blood or mucus, you should immediately consult a doctor.

In rare cases, it causes amoksiklav cholestatic jaundice, so the duration of the treatment medication without medical supervision should not exceed fourteen days. If yellowing of the eyes or skin, immediately see a doctor. This side effect is most common in men over 65 years.

Amoxiclav should be used with caution in the following cases:

• renal insufficiency;
• hepatic impairment;
• allergic reactions;
• increased sensitivity to antibiotics Antibiotics - whether they will help you in the foreseeable future?   the group of penicillins, cephalosporins and other beta-lactam antibiotics (in history);
• pseudomembranous colitis in history;
• acute or chronic lymphoid leukemia or cytomegalovirus Cytomegalovirus - what is its danger?   (reception amoxiclav may cause a skin rash).

Pregnancy and breast-feeding

Amoxicillin and clavulanic acid penetrate in small amounts into breast milk and may harm a child's health. Amoxiclav can be used in pregnancy if the expected benefit to the mother outweighs the potential risk to the fetus. Be sure to tell your doctor you are expecting a child ate or planning a pregnancy.

Overdose

No information on the occurrence of fatal or life-threatening side effects due to an overdose amoksiklava.

Application of porphyria

Amoxiclav can be taken when porphyria.

Application for the treatment of the elderly

Amoxiclav no restrictions applied to the treatment of the elderly.