Flemoksin soljutab - broad-spectrum antibiotic that is widely used in the treatment of infectious and inflammatory diseases caused by susceptible to the pathogens. This infection of the upper and lower respiratory tract, kidney and urinary tract, gynecological diseases.

The mechanism of action flemoksin Solutab

Flemoksin soljutab (INN - amoxicillin) is a semisynthetic antibiotic penicillin group. Dutch drug produced by the pharmaceutical company "Astellas Pharma Europe BV" in tablets for oral administration.

Semisynthetic penicillins produced from natural penicillin (penicillin and was obtained from fungi), slightly changing its chemical structure. Drugs that kill a number of pathogens (bactericidal action), blocking the synthesis of components of cell membranes.

Sensitivity to exhibit various types of staphylococcus, streptococcus, E. coli, as well as agents of dysentery, salmonellosis, gonorrhea, meningococcal infection, chlamydia, gastric ulcer and duodenal ulcers (Helicobacter pylori) and other infectious agents.

But flemoksin soljutab has one characteristic feature common to all the antibiotics penicillin: it is destroyed by the enzyme penicillinase (beta-lactamase) that produce certain types of microorganisms. Therefore infectious agents that produce penicillinase to flemoksin soljutab insensitive.

Flemoxin Solutab not destroyed in the stomach by the action of acid, so its release tablets for oral administration. Upon receiving the tablets it is rapidly absorbed in the gastrointestinal tract, it enters the bloodstream and is distributed in tissues and body fluids. Substantial concentrations of drug are in broncho-pulmonary system, the kidneys and the urinary tract in the abdominal cavity. Then flemoksin soljutab decomposed in the liver and excreted by the kidneys as metabolites.

Indications and contraindications for use flemoksin Solutab

Flemoksin soljutab prescribed for infectious and inflammatory diseases caused by microorganisms sensitive to it:

• bronchopulmonary system - acute and chronic bronchitis, pneumonia, pleurisy;
• Otolaryngology - angina, exacerbation of chronic tonsillitis Chronic tonsillitis - inflammation of the tonsils , Adenoiditis, acute and chronic sinusitis (inflammation of the sinuses), pharyngitis, otitis;
• kidney and urinary tract infections - acute and chronic pyelonephritis, cystitis, urethritis;
• genitals - adnexitis Adnexitis as a consequence of frequent change of partners , Prostatitis, orchitis, endometritis, including those caused by gonococcal infection;
• gastrointestinal tract - stomach ulcer and duodenal ulcer (must be laboratory confirmation of the presence of gastric contents bacteria Helicobacter pylori), typhoid, paratyphoid, salmonellosis Salmonellosis - features of the disease Dysentery;
• Biliary - cholangitis, cholecystitis;
• skin and subcutaneous tissue;
• brain caused by bacterial infection, including meningococcal;
• infectious diseases such as borreliosis;
• before surgery to prevent the bacterial complications;
• when endocarditis - infection of the inner lining of the heart.

Admission flemoksin Solutab ® is contraindicated in the following conditions:

• hypersensitive to the components of the drug;
• infectious mononucleosis, and some types of leukemia;
• serious infectious diseases of the digestive system, accompanied by persistent vomiting, diarrhea and dehydration, as well as in ulcerative colitis;
• viral diseases;
• severe kidney disease in violation of their functions.

During pregnancy and nursing Breastfeeding - a personal choice   breast flemoksin soljutab administered only if the expected positive effects from its use outweigh the risks of side effects. Precautions flemoksin salyutab also nominated for allergic diseases.

Side effects that may occur while taking flemoksin Solutab and possible overdose

Side effects that occur while taking flemoksin Solutab:

• from the gastrointestinal tract - a violation of appetite, nausea, vomiting, diarrhea, flatulence, colitis;
• from the liver - a violation of its functions;
• by the kidneys and urinary tract - the development of the inflammatory process in the kidneys infectious nature;
• from the blood - reducing the number of leukocytes, platelets and red blood cells;
• allergic reactions - different types of rashes, angioedema.

Overdosing causes increased side effects.

Flemoksin soljutab - an effective antibiotic penicillin.

Galina Romanenko

Orungal - tablets (more correctly - the capsule) are used to treat the most common fungal diseases of the mucous membranes, skin, and systemic (affecting the entire body) fungal infections. Only a few species are quite rare pathogens fungal infections show no sensitivity to this drug.

Orungal - tablets (capsules) of fungal infection

Orungal - is an antifungal drug that produces a Belgian pharmaceutical company Janssen Pharmaceutica in dosage forms for oral administration. One such dosage form is a capsule, but as with all drugs, which are taken inside the capsule is often called pills.

The composition of each capsule includes a main active ingredient - itraconazole (100 mg) and adjuvants - sucrose, hypromellose, macrogol. The capsule composition includes titanium dioxide, indigotine, azorubin gelatin.

Active ingredient orungala Orungal - antifungal broad spectrum   itraconazole suppresses the formation of ergosterol in fungal cell membranes, which leads to death of these cells. When taking capsules orungala they are rapidly absorbed in the gut, but absorption may be impaired with reduced gastric acidity. Therefore, patients with low acidity gastric juice is better to take orungal Coke. After absorption, the blood enters the orungal tissue (skin, mucous membranes, and nails), which accumulates at concentrations several times greater than in the blood. Slightly lower concentrations orungal accumulates in internal organs. After the decomposition products of metabolism in the liver orungal excreted in the urine and feces.

Sensitivity to tablets orungal show most pathogens fungal infections caused by fungal infections of the skin, mucous membranes and internal organs, including the brain (systemic mycosis). Insensitive to tablets orungal only some pathogens is quite rare fungal infections, including tropical.

Which diseases can be used tablets orungal

The tablets are used for the following orungal mycosis (fungal infections) caused by susceptible pathogens to the drug:

• when vulvovaginal candidiasis (thrush genitals);
• candidiasis of the gastrointestinal tract - Thrush Stomatitis - to breath fresh   and candidiasis of the esophagus, stomach and intestines;
• fungal lesions of the organs of vision - fungal keratitis;
• fungal skin lesions, including the otrubevidnom (multicolored) lichen;
• fungal nail infections - onihomikozah;
• in systemic fungal diseases that affect internal organs, including the brain - aspergillosis, candidiasis, cryptococcosis, histoplasmosis, sporotrichosis, paracoccidioidomycosis, blastomycosis;
• for the prevention of systemic fungal infections in patients with AIDS, cancer, and in patients after transplantation of organs or bone marrow.

To tablets are contraindicated orungal

Tablets orungal contraindicated if you are hypersensitive their components by the body of the patient during pregnancy, infant feeding Breastfeeding - a personal choice   breast, and while taking certain drugs that are degraded in the liver, with the participation of the same enzyme that orgunal, - CYP3A4 - terfenadine, astemizole, mizolastine, cisapride, dofetilide, quinidine, pimozide, sertindole, Levo, triazolam, midazolam, simvastatin, lovastatin. It does not take orungal simultaneously with the reception of ergot alkaloids such as dihydroergotamine, ergometrine, ergotamine and metilergometrin.

Precautions taken orungal in the human liver, kidney, and cardiovascular disease. Special care is required the appointment of the drug to children and elderly patients.

Orungal tablets - if they have any side effects?

Orungal tablets may cause a decrease in the force of contraction of the heart muscle (negative inotropic effect), and this in turn will lead to stagnation in the large and small circles of blood circulation - the appearance of edema, shortness of breath and so on. That is why it is not trying to prescribe to patients with cardiovascular insufficiency and elderly patients.

Sometimes pill orungal may experience headaches, dizziness, neuritis of peripheral nerves, nausea, vomiting, abdominal pain Abdominal pain: Types and Symptoms , Transient liver dysfunction (very seldom - toxic hepatitis), in women - menstrual disorders, hair loss. Allergic reactions are also possible.

Tablets orungal help get rid of the majority of the most common fungal infections.

Galina Romanenko