Fluconazole - an antibiotic with antifungal effect, used to treat various types of infections caused by fungal organisms and affecting the mouth, throat, esophagus, lungs, bladder, Urinary bladder - structure and function , Genitals and the blood. Furthermore, Fluconazole is used for preventing fungal infections in the case of immunosuppressed provoked anti-cancer therapy, bone marrow transplantation or diseases such as AIDS.

Fluconazole is not recommended for use if you are allergic to the drug or similar drugs - including clotrimazole, econazole, ketoconazole, miconazole, sertaconazole terconazole, tioconazole and voriconazole. Fluconazole is contraindicated while cisapride treatment. The drug is not used to treat viral infections - such as the common cold or flu. Take fluconazole is necessary throughout the due date, even if the effect of the drug suppresses the symptoms within a few days after the start of treatment.

The recommended dose of fluconazole depends on the type of infection, which is used to treat drug. In the case of vaginal infections, usually required only one dose in the case of other infections may be advised by a double dose of fluconazole.

Use for the treatment of fungal infections in adults

The recommended dosing regimen for the treatment of infections triggered by fungal pathogens in adults are:

• For treatment of vaginal candidiasis Vaginal candidiasis - Treatment: in the fight against the fungus A hundred and fifty milligrams of fluconazole once orally.
• For the treatment of thrush Treating Thrush: how to get rid of bad fungus   oral: Two hundred milligrams of fluconazole in the first day of treatment, then - hundred milligrams of the drug orally or intravenously every day. The duration of treatment is at least two weeks to prevent re-infection.
• For the treatment of candidemia: four hundred milligrams of fluconazole in the first day of treatment, then - two hundred milligrams of the drug either intravenously or orally once a day. Duration of treatment is at least four weeks.
• For treating mycotic pneumonia four hundred milligrams of fluconazole in the first day of treatment, then - two hundred milligrams of the drug either intravenously or orally once a day.
• For the treatment of esophageal candidiasis two hundred milligrams of fluconazole in the first day of treatment, then - hundred milligrams of the drug orally or intravenously every day. Dosage can be increased to four hundred milligrams per day depending on the response of the patient to treatment. Duration of treatment is at least three weeks.
• For treatment of fungal infections of the urinary tract and fungal peritonitis from fifty to two hundred milligrams of fluconazole orally or intravenously every day.

Use for the treatment of fungal infections in children

The recommended dosage of fluconazole for children under the age of two weeks (gestational age from twenty-six to twenty-nine weeks) is calculated based on the ratio of three to twelve milligrams per kilogram of body weight of the child. The drug is taken orally or intravenously every seventy-two hours.

For children older than two weeks fluconazole applied at a rate of six milligrams of drug per kilogram of body weight on the first day, then - three fluconazole milligram per kilogram of body weight per day of the child. The duration of treatment with fluconazole Fluconazole - used with caution   usually at least three weeks.

Flemoksin soljutab - broad-spectrum antibiotic that is widely used in the treatment of infectious and inflammatory diseases caused by susceptible to the pathogens. This infection of the upper and lower respiratory tract, kidney and urinary tract, gynecological diseases.

The mechanism of action flemoksin Solutab

Flemoksin soljutab (INN - amoxicillin) is a semisynthetic antibiotic penicillin group. Dutch drug produced by the pharmaceutical company "Astellas Pharma Europe BV" in tablets for oral administration.

Semisynthetic penicillins produced from natural penicillin (penicillin and was obtained from fungi), slightly changing its chemical structure. Drugs that kill a number of pathogens (bactericidal action), blocking the synthesis of components of cell membranes.

Flemoksin soljutab is sufficiently robust antibiotic with a broad spectrum of action. Sensitivity to exhibit various types of staphylococcus, streptococcus, E. coli, as well as agents of dysentery, salmonellosis, gonorrhea, meningococcal infection, chlamydia, gastric ulcer and duodenal ulcers (Helicobacter pylori) and other infectious agents.

But flemoksin soljutab has one characteristic feature common to all the antibiotics penicillin: it is destroyed by the enzyme penicillinase (beta-lactamase) that produce certain types of microorganisms. Therefore infectious agents that produce penicillinase to flemoksin soljutab insensitive.

Flemoxin Solutab not destroyed in the stomach by the action of acid, so its release tablets for oral administration. Upon receiving the tablets it is rapidly absorbed in the gastrointestinal tract, it enters the bloodstream and is distributed in tissues and body fluids. Substantial concentrations of drug are in broncho-pulmonary system, the kidneys and the urinary tract in the abdominal cavity. Then flemoksin soljutab decomposed in the liver and excreted by the kidneys as metabolites.

Indications and contraindications for use

Flemoksin soljutab prescribed for infectious and inflammatory diseases caused by microorganisms sensitive to it:

• bronchopulmonary system - acute and chronic bronchitis, pneumonia, pleurisy;
• Otolaryngology - angina, exacerbation of chronic tonsillitis Chronic tonsillitis - inflammation of the tonsils , Adenoiditis, acute and chronic sinusitis (inflammation of the sinuses), pharyngitis, otitis;
• kidney and urinary tract infections - acute and chronic pyelonephritis, cystitis, urethritis;
• genitals - adnexitis Adnexitis as a consequence of frequent change of partners , Prostatitis, orchitis, endometritis, including those caused by gonococcal infection;
• gastrointestinal tract - stomach ulcer and duodenal ulcer (must be laboratory confirmation of the presence of gastric contents bacteria Helicobacter pylori), typhoid, paratyphoid, salmonellosis Salmonellosis - features of the disease Dysentery;
• Biliary - cholangitis, cholecystitis;
• skin and subcutaneous tissue;
• brain caused by bacterial infection, including meningococcal;
• infectious diseases such as borreliosis;
• before surgery to prevent the bacterial complications;
• when endocarditis - infection of the inner lining of the heart.

Admission flemoksin Solutab ® is contraindicated in the following conditions:

• hypersensitive to the components of the drug;
• infectious mononucleosis, and some types of leukemia;
• serious infectious diseases of the digestive system, accompanied by persistent vomiting, diarrhea and dehydration, as well as in ulcerative colitis;
• viral diseases;
• severe kidney disease in violation of their functions.

During pregnancy and nursing Breastfeeding - a personal choice   breast flemoksin soljutab administered only if the expected positive effects from its use outweigh the risks of side effects. Precautions flemoksin salyutab also nominated for allergic diseases.

Side effects

Side effects that occur while taking flemoksin Solutab:

• from the gastrointestinal tract - a violation of appetite, nausea, vomiting, diarrhea, flatulence, colitis;
• from the liver - a violation of its functions;
• by the kidneys and urinary tract - the development of the inflammatory process in the kidneys infectious nature;
• from the blood - reducing the number of leukocytes, platelets and red blood cells;
• allergic reactions - different types of rashes, angioedema.
• Overdosing causes increased side effects.
• Flemoksin soljutab - an effective antibiotic penicillin.

Galina Romanenko