Vilprafen - a modern macrolide antibiotic. He has an active antibacterial action and almost no side effects and contraindications. Vilprafen is considered the drug of choice for the treatment of bacterial, Chlamydia and Mycoplasma infections in pregnant women.

The mechanism of action Wilprafen

Vilprafen (INN - josamycin) - a macrolide antibiotic that is produced by different pharmaceutical companies in the following dosage forms:

• in the form of tablets for oral use, coated tablets - each tablet contains 500 mg of josamycin;
• as a suspension for oral administration in bottles of 100 ml with a measured glass - 10 ml of the suspension contains 300 mg of josamycin;
• soljutab in pill form (dispersible - fast) - Each tablet contains 1000 mg of josamycin.

The mechanism of action Wilprafen associated with inhibition of protein synthesis of bacteria cells. In normal concentrations it has a bacteriostatic effect (suppress the vital activity of infectious agents), and high - bactericidal (killing them).

Wilprafen peculiarity is that it shows high activity against intracellular pathogens infections - chlamydia, mycoplasma, ureaplasma, legionella. Sensitivity to vilprafenu also exhibit gram (staphylococcus, streptococcus, diphtheria bacillus), Gram-negative bacteria (pathogens of meningitis, gonorrhea, Haemophilus influenzae) and certain anaerobic (developing without air) bacteria.

Vilprafen also hardly suppresses the natural gut flora and in recommended doses does not cause dysbiosis. It is also active against the infectious agents resistant (refractory) to erythromycin - the first representative of the macrolide.

When administered vilprafen rapidly absorbed in the intestine and enters first into the bloodstream, and then in the tissue mainly in the tissues and organs of upper airway. In the tissues of these organs it is in much higher concentrations than in the blood. Then vilprafen decomposed in the liver and excreted in the bile and feces, some of it is excreted in the urine.

When pregnancy vilprafen crosses the placenta to the fetus, and during breast Breastfeeding - a personal choice   breast - in mother's milk.

Indications and contraindications

Vilprafen is prescribed for treatment of the following infectious and inflammatory processes caused by susceptible to infectious agents:

• in the upper respiratory tract and upper respiratory tract - acute purulent tonsillitis, chronic tonsillitis, pharyngitis, laryngitis, tracheitis, otitis, sinusitis, sinusitis;
• in the lower equipment Respiratory acute and chronic bronchitis, pneumonia, including those caused by atypical pathogens infection - mycoplasma, chlamydia Chlamydia: insidious and widespread disease , Legionella, viruses;
• in the oral cavity and in periodontal tissue - gingivitis, periodontitis, stomatitis;
• in the field of eye - blepharitis (inflammation of the eyelid margins), and dacryocystitis (inflammation of the nasolacrimal duct);
• in the field of skin and soft tissue - pustular, including acne, rashes, boils, inflammation of the walls of the lymphatic vessels and lymph nodes, erysipelas skin;
• Infectious diseases - diphtheria, pertussis This pest, pest whooping ... , Scarlet fever, anthrax;
• Psittacosis some species (such as psittacosis, or parrot disease, which is caused by a type of chlamydia) - diseases transmitted by birds;
• Some sexually transmitted diseases (gonorrhea, syphilis, lymphogranuloma venereum) and infections, sexually transmitted infections (chlamydia, mycoplasma, ureaplasma);
• urinary tract infections - urethritis, cystitis, pyelonephritis.

Contraindications reception Wilprafen are hypersensitive to its components, the body of the patient and in severe liver disease with impaired function of the body. With caution and under the supervision of laboratory parameters vilprafen Vilprafen - modern highly effective and non-toxic antibiotic   prescribed for violations of renal function.

Side effects and overdose Wilprafen

Vilprafen usually very well tolerated, but may cause side effects and:

• the part of the digestive system - disturbances of appetite, heartburn, nausea, vomiting, diarrhea, dysbiosis (including intestinal candidiasis, very rarely - pseudomembranous colitis), liver dysfunction (in the form of changes in laboratory parameters of liver function and jaundice);
• on the part of the organ of hearing - hearing loss when taking high doses of the drug, which comes in the wake of its cancellation;
• Allergic reactions are rare and are manifested as urticaria.

Overdose Wilprafen rare and appears increasing side effects.

Galina Romanenko

Betadine Ointment - broad-spectrum antiseptic for external use only recommended for use for the prevention of infections in areas of shallow cuts, minor injuries and skin burns. Additionally, Betadine solution for treating fungal and bacterial infections of the skin and pyoderma (gnoynichnokoy skin disease).

Betadine contains povidone iodine - iodine complex that preserves the bactericidal activity and broad spectrum of activity normal iodine, but is characterized by the absence of its inherent flaws.

How to apply betadine

Betadine Ointment is for external use only. For the treatment of infections must be treated with Betadine affected skin once or twice a day for no more than fourteen days. The prevention of infection ointment should be applied on the affected area of ​​skin once or twice a week for as long as required. Prior to treatment with betadine skin should be clean and dry. After applying the ointment-treated area of ​​the skin can be closed with a bandage or plaster or leave open. The ointment is not recommended for children under two years.

In some cases, it is not recommended to apply betadine?

Betadine is contraindicated for use in cases of confirmed or suspected hypersensitivity to iodine. Also, do not recommend regular use of Betadine in the case of thyroid disease (especially when gnarled colloid goiter, endemic goitre Endemic goiter - if not enough iodine , Hashimoto's thyroiditis (autoimmune thyroiditis). Particular attention is required for a regular treatment of damaged skin with betadine in the case of kidney failure. Not recommended for regular use betadine with simultaneous lithium therapy.

Regular application of Betadine is not recommended for pregnant or lactating women as absorbed iodine can enter the body through the placenta and breast milk, thus affecting the thyroid function of the child.

Povidone-iodine can cause local irritation of the skin, although the skin has far less irritating than conventional iodine. Processing betadine skin areas with deep cuts or burns a large area can cause a number of systemic side effects - including metabolic acidosis, hypernatremia, renal malfunction. Excess iodine can cause goiter, hypothyroidism or hyperthyroidism Hyperthyroidism: increased secretion of thyroid hormone . In addition, in some cases, there may be side effects such as a metallic taste in the mouth, excessive salivation Profuse salivation - find out the cause Pain or burning sensation in the throat or mouth, skin reactions, a disorder of the gastrointestinal tract and diarrhea.

Shelf life of thirty-six months. Keep betadine Betadine - use correctly   must be in a cool, dry and dark place at a temperature of air in the twenty-five degrees Celsius or below.