Aescusan - a herbal medicinal products, which tones vein walls and reduces their permeability, that is, removes the tissue edema and venous stasis. Apply Aescusan venous insufficiency - it removes the feeling of tiredness in the legs, cramps in the calf muscles, pain and itching of hemorrhoids Hemorrhoids - a shameful disease .

The mechanism of action Aescusan

Aescusan - a drug of plant origin, which is used as a drug for the symptomatic treatment (withdrawal symptoms) in violation of venous circulation. Produced Aescusan as an alcoholic solution for oral administration in vials (1 ml contains 10 mg escin and 5 mg thiamine chloride) in the form of tablets Aescusan 20 coated oral (each tablet contains 250 mg dry extract of horse chestnut in including 20 mg of escin).

Active substances are Aescusan extract of horse chestnut and thiamine. The composition of the horse chestnut extract contains several biologically active substances, including flavonoids, which reduces the permeability of blood vessels.

But the main active ingredient of horse chestnut extract is escin - triterpene glycoside having the ability to tone up the walls of veins and eliminate venous congestion. Mechanism venotonic escin associated with stimulation of release of adrenal hormones (primarily norepinephrine) that contribute to the narrowing of blood vessels.

Escin is also capillary protector, that is, it beneficially affects the capillaries: normalizes their vascular wall, increases the resistance of the capillaries with respect to the various adverse effects, protects against the action of toxic substances, and decreases the brittleness. Escin also inhibits the action of the enzyme hyaluronidase breaks down hyaluronic acid, which gives the elastic walls of the veins, attracting the liquid.

Escin well reduces swelling of tissues, since under its influence reduced permeability of capillaries, facilitates emptying of varicose veins, improves limfootok. In addition, escin has anti-inflammatory, analgesic and antioksidantnoe (inhibit the toxic effects of free radicals) effect, improves blood flow in the capillaries, reduces the risk of blood clots, restores normal organs and tissues. With already established venous insufficiency Aescusan reduces symptoms, but does not eliminate the disease process itself.

Indications and contraindications for appointment

Aescusan used in chronic venous insufficiency Venous insufficiency - rapidly Youthful disease   against the background of varicose veins Varicose veins - the operation is inevitable?   lower limbs and post-thrombotic syndrome (post-thrombotic syndrome develops after suffering a thrombosis). Aescusan helps relieve symptoms such as swelling of the lower limbs, cramps in the calf muscles, feeling of heaviness in the legs, feet on the appearance of varicose veins and nets trophic disorders (eg, pruritus, venous ulcers) and in the rectal area - hemorrhoids.

Aescusan also applied to reduce inflammation and swelling occurring after injuries and operations.

Take Aescusan in a solution of 12-15 drops three times daily before meals, washed down with a small amount of liquid. The solution was agitated thoroughly before taking. Tablets Aescusan 20 taken after meals three times a day, the dose may be increased to two tablets three times a day. The course of treatment lasting at least three months.

Aescusan only contraindicated in case of hypersensitivity to it, and the body of the patient with chronic renal failure. Do not take alcohol solution Aescusan and tablets to pregnant women and nursing mothers.

Side effects and possible overdose

Aescusan drug is nontoxic and practically no side effects other than allergic reactions which may occur in the form of various types of itchy, inflammation and edema.

It is very rare when taking Aescusan Aescusan - help with venous insufficiency   mucosal irritations of the gastro-intestinal tract as pain in the upper abdomen, nausea and vomiting. In this case, it is recommended to take Aescusan only during meals.

No cases of overdose Aescusan has not yet met, but we can assume that in this case any symptoms of irritation of the gastrointestinal tract.

Aescusan - a drug for the symptomatic treatment of varicose veins, post-thrombotic syndrome and hemorrhoids. In these diseases, it contributes to a significant reduction of swelling, heaviness and fatigue in the legs, tension, itching, pain.

Galina Romanenko

Dicynonum as a solution in ampoules is most often used in cases of emergency, when an urgent need to stop or prevent bleeding. This dosage form Dicynonum used in the treatment of hemorrhagic diathesis, hemorrhages, heavy uterine bleeding Uterine bleeding outside of menstruation - a sign of a serious breach Including in labor.

How does Dicynonum ampoules

Dicynonum - a drug that helps stop bleeding and reduce excessive bleeding by increasing the clotting ability of the blood, increase in blood platelets, strengthening the vascular wall and reduce its permeability, as well as the improvement of blood - her movement in the small blood vessels - capillaries. Dicynonum does not affect the normal levels of blood clotting. One vial contains 2 ml of solution (125 mg in 1 ml) for intravenous or intramuscular administration.

When intravenously Dicynonum therapeutic effect is achieved after 10 minutes, the maximum effect is achieved after two hours and the effect lasts for six hours. Dicynonum distributed in the body, penetrate into the brain tissue, it overcomes the placental barrier and into the fetal tissues, is excreted in human milk. In intramuscular Dicynonum its therapeutic effect is somewhat slower. More than 70% of the injected intravenously or intramuscularly Dicynonum displayed throughout the day with urine in unchanged form.

Indications for use

Dicynonum as a solution in the ampoule is applied:

• for the prevention and treatment of bleeding during surgery, especially if the surgery is performed on fabrics with advanced capillary circulation; Dicynonum often used in operations in gynecology, urology, otolaryngology, ophthalmology and plastic surgery;
• for the prophylaxis and treatment of internal and external bleeding after injury;
• for the treatment of internal bleeding in various diseases of internal organs, such as stomach or intestinal bleeding against the backdrop of gastric ulcer and duodenal ulcer;
• with significant uterine bleeding, developed on the background of gynecological diseases such as endometriosis, uterine fibroids, hormonal disorders with severe menstrual irregularities and heavy menstrual or intermenstrual bleeding;
• when medicinal bleeding, for example, on the background of indirect anticoagulants, or ascorbic acid;
• diseases of the blood system, that manifest hemorrhagic syndrome arising in light of changes in blood vessels;
• with hemorrhages in the retina of the eye and its prevention in patients with diabetes;
• due to birth injury Birth injuries - than they threaten your child?   in newborns, which are accompanied by intracranial hemorrhages;
• Topical: Dicynonum moistened with a solution of sterile cloth or swab How to use sanitary pad - basic precautions   and applied to a wound (for example, after extraction).

This use is contraindicated in ampoules Dicynonum

Contraindications for the purpose Dicynonum ampoules are:

• tendency to thrombosis, thrombophlebitis and thrombosis and embolism (blood clot separation) in the past;
• certain types of leukemia (lymphocytic and myeloid) and bone sarcoma in children;
• acute porphyria - severe violations of pigment metabolism;
• breast-feeding Breastfeeding - a personal choice   breast;
• individual intolerance of components.

With caution, taking into account the indications and contraindications Dicynonum administered during pregnancy. Dicynonum ampoules are applied only in a medical institution. If the solution in the vial has changed its color, it is not used. Dicynonum is not compatible with other drugs - it can not be administered to them in the same syringe.

Side effects

Dicynonum - a drug that is very well tolerated and rarely has side effects. Yet side effects are:

• of the central and peripheral nervous system - headache, dizziness, various types of sensory disturbances of the lower extremities;
• from the gastrointestinal tract - nausea, vomiting (rare), heartburn, discomfort in the stomach;
• allergic reactions - urticaria, angioedema, sometimes (very rarely) - anaphylactic shock;
• further adverse effects - redness of skin, reduction of the upper (systolic) arterial pressure.

Data on overdose Dicynonum manufacturers were not provided, but obviously they are manifested in the form of increased side effects.

Dicynonum ampoules - a formulation that is used in an emergency or in the treatment of critically ill patients in the hospital or clinic.

Galina Romanenko