Nise - a drug which is the generic Nimesulide Nimesulide - promising Analgesic drug   - The first original drug, the Swiss pharmaceutical company released Helsinn Healthcare SA in the eighties of the last century (generics have the right to make any farmfirmy after the end on the original drug patent). Nise their properties do not differ from the original drug, the only difference in the price (Nise is quite inexpensive).

At the time, the Swiss pharmaceutical company Helsinn Healthcare SA has made a real revolution in the production of drugs belonging to the group of non-steroidal anti-inflammatory drugs (NSAIDs), releasing the first drug nimesulide, which selectively inhibits the activity of the enzyme cyclooxygenase-2 (COX-2).

The problem was that the enzyme cyclooxygenase (COX) in the body exists in two forms: COX-1 and COX-2. COX-1 has a protective effect, in particular, protects the gastric mucosa from irritation by various substances. While COX-2 activates the formation of prostaglandins - substances that are directly involved in the inflammatory process.

Traditional NSAIDs inhibited both types of COX. These drugs include aspirin, indomethacin, ibuprofen, diclofenac Diclofenac - relieve inflammation and pain   and many other drugs. Since many patients (eg, chronic diseases of joints and spine, which are accompanied by severe pain) had to take them a long time, they often develop erosive and ulcerative processes in the stomach.

The first drug that has a selective (selective) effects on COX-2 (nimesulide), significantly reduced (according to some researchers twice) the number of complications in the gastrointestinal tract. But do not think that nimesulide and other drugs that selectively inhibit COX-2, does not affect the function of COX-1. Some overwhelming influence is still there, because the COX - a single enzyme. Therefore conscientious manufacturers in this case always point in the instruction possibility of side effects from the gastrointestinal tract.

The mechanism of action Naiza

Generic Nise (nimesulide international nonproprietary name) produced an Indian pharmaceutical company Dr. Reddy's Laboratories Ltd tablets. This drug is no worse than the original drug.

Besides inhibiting the function of COX-2 also has nize antithrombotic action by inhibiting the function of the blood coagulation system and reducing blood platelet count. This leads to increased bleeding and prolonged bleeding. With prolonged use of the drug can cause anemia and reduced immunity. Negative properties Naiza is also toxic to the liver, and therefore it is not recommended for children under 12 years.

A new and promising field of application can be Naiza treatment of cancer, as selective COX-2 inhibitors have antitumor activity. They inhibit the growth of tumor cells and tumor invasion eat the blood vessels.

Still, the main advantage Naiza as other drugs from the group of selective inhibitors of COX-2 is a much smaller risk of developing serious complications from the gastrointestinal tract as compared to conventional NSAIDs.

Various NSAIDs are used for various purposes since they have both their individual properties. For example, Nise used as anti-inflammatory and analgesic, antipyretic properties had less pronounced. Assign Nise mostly patients with long flowing inflammatory and metabolic diseases of the joints (arthritis, arthrosis) and spine (eg, ankylosing spondylitis Ankylosing spondylitis - a lot of patience is required , Scoliosis), which are accompanied by severe pain. It is used for a long time as part of combination therapy. Helps Nise and in pain at other sites - dental, ear, head, pain during menstruation.

Contraindications for receiving Naiza

Nise has many contraindications - mainly diseases of the organs to which it has a negative effect: stomach ulcers and gastritis, severe liver disease in violation of its function, increased bleeding. It is not recommended to use it also at individual intolerance, pregnancy, during lactation and children under 12 years.

At the same target organs extends side effects of the drug. In some patients, it causes nausea, vomiting, abdominal pain Abdominal pain: Types and Symptoms , Abnormal liver function, bleeding, anemia, decreased immunity.

Nise - attorney time a drug that causes far fewer complications than traditional NSAIDs.

Galina Romanenko

Breast sciatica - a condition that affects the roots of the spinal cord in the thoracic spine. This kind of sciatica occurs much less frequently than sciatica lumbar and cervical spine.

The causes of this disorder are:

• Age-related changes, which resulted in a slow destruction of cartilage and bone tissue;
• Hernia;
• Osteoarthritis;
• Damage to the spine;
• Spinal stenosis;
• Diabetes, especially in the elderly.

Symptoms of breast sciatica

Typical symptoms of sciatica are breast-radiating pain and parasthesia - violation of the sensitivity in which the patient feels a slight tingling or numbness in certain parts of the body. Pain, the source of which is in the thoracic spine, it may be given to other areas of the body, depending on where it is struck by the spine cord. For example, if it is in the area of ​​vertebra T4, the pain may be felt in the chest at the level of the nipple, if it is located at a vertebra T10 - at the level of the navel, and the defeat of the spinal cord in the vicinity of the first vertebra of the thoracic - T1, often causes pain in the hands and forearms. These symptoms often cause trouble for patients and somewhat difficult to diagnose because they resemble symptoms of several other disorders such as angina Angina: When the heart needs help , Dyspepsia, or diverticulitis.

Diagnostics

Sciatica thoracic usually diagnosed using radiography, computed tomography or magnetic resonance imaging. In the differential diagnosis is necessary to exclude violations such as postherpetic neuralgia Neuralgia - the scourge of the elderly , Malignant tumors, compression of the intervertebral disc. Some experts suggest that a significant portion of cases of sciatica Sciatica - ask for help in a timely manner   thoracic remains undetected both because of the fact that patients do not always seek medical help if symptoms of this disorder and due to errors in diagnosis.

Treatment of breast sciatica

Most patients diagnosed sciatica thoracic spine, primarily prescribe conservative treatment. It is effective in about one-third of all cases.

Acute symptoms of breast relieve sciatica as well as in the cases of cervical and lumbar radiculitis Lumbar sciatica: how to get rid of pain : Appointed by the use of nonsteroidal anti-inflammatory drugs, it is recommended to reduce physical exertion and sometimes - to comply with bed rest for several days. With a very strong pain doctor may prescribe steroids and opioid analgesics.

However, in some cases, the above methods of treatment fail, and to alleviate the symptoms of breast sciatica and prevent further damage, which can lead to serious problems with the spine can be used:

• Epidural steroid injections - a procedure used to reduce inflammation and relieve pain caused by inflammation. Local injection allow to stop the inflammation minimum dose steroids, and sweep to minimize the impact of these drugs in other parts of the body;
• Percutaneous disc decompression may be imposed in cases where the cause of sciatica was the thoracic intervertebral hernia. This new minimally invasive procedure allows you to quickly and with little risk to the health of the patient to cope with this disorder;
• Percutaneous vertebroplasty - a minimally invasive procedure is one that can be used in the treatment of breast sciatica .  It lasts from an hour to two hours and is usually performed under local anesthesia .  To ensure patient comfort during the procedure, they may also be administered a mild sedative .  During the procedure, the body of the damaged vertebra injected polymethyl methacrylate - a special cementing substance .  Over the next few days, the patient may be required analgesics or muscle relaxants to relieve pain and muscle spasms after surgery .  However, after a few weeks, a large part of the patients completely pain persists or becomes very weak and makes itself felt only occasionally .  Serious complications (infection, severe allergic reaction, severe bleeding) after this procedure are found in less than 1% of patients .

Whether used to treat sciatica thoracic surgical or conservative methods, patients are also encouraged to undergo physical therapy, and use a variety of additional ways to alleviate the symptoms of this disorder - hot and cold compresses, massage, electrical, and so on.