Nise - a drug which is the generic Nimesulide
Nimesulide - promising Analgesic drug
- The first original drug, the Swiss pharmaceutical company released Helsinn Healthcare SA in the eighties of the last century (generics have the right to make any farmfirmy after the end on the original drug patent). Nise their properties do not differ from the original drug, the only difference in the price (Nise is quite inexpensive).
At the time, the Swiss pharmaceutical company Helsinn Healthcare SA has made a real revolution in the production of drugs belonging to the group of non-steroidal anti-inflammatory drugs (NSAIDs), releasing the first drug nimesulide, which selectively inhibits the activity of the enzyme cyclooxygenase-2 (COX-2).
The problem was that the enzyme cyclooxygenase (COX) in the body exists in two forms: COX-1 and COX-2. COX-1 has a protective effect, in particular, protects the gastric mucosa from irritation by various substances. While COX-2 activates the formation of prostaglandins - substances that are directly involved in the inflammatory process.
Traditional NSAIDs inhibited both types of COX. These drugs include aspirin, indomethacin, ibuprofen, diclofenac
Diclofenac - relieve inflammation and pain
and many other drugs. Since many patients (eg, chronic diseases of joints and spine, which are accompanied by severe pain) had to take them a long time, they often develop erosive and ulcerative processes in the stomach.
The first drug that has a selective (selective) effects on COX-2 (nimesulide), significantly reduced (according to some researchers twice) the number of complications in the gastrointestinal tract. But do not think that nimesulide and other drugs that selectively inhibit COX-2, does not affect the function of COX-1. Some overwhelming influence is still there, because the COX - a single enzyme. Therefore conscientious manufacturers in this case always point in the instruction possibility of side effects from the gastrointestinal tract.
The mechanism of action Naiza
Generic Nise (nimesulide international nonproprietary name) produced an Indian pharmaceutical company Dr. Reddy's Laboratories Ltd tablets. This drug is no worse than the original drug.
Besides inhibiting the function of COX-2 also has nize antithrombotic action by inhibiting the function of the blood coagulation system and reducing blood platelet count. This leads to increased bleeding and prolonged bleeding. With prolonged use of the drug can cause anemia and reduced immunity. Negative properties Naiza is also toxic to the liver, and therefore it is not recommended for children under 12 years.
A new and promising field of application can be Naiza treatment of cancer, as selective COX-2 inhibitors have antitumor activity. They inhibit the growth of tumor cells and tumor invasion eat the blood vessels.
Still, the main advantage Naiza as other drugs from the group of selective inhibitors of COX-2 is a much smaller risk of developing serious complications from the gastrointestinal tract as compared to conventional NSAIDs.
Various NSAIDs are used for various purposes since they have both their individual properties. For example, Nise used as anti-inflammatory and analgesic, antipyretic properties had less pronounced. Assign Nise mostly patients with long flowing inflammatory and metabolic diseases of the joints (arthritis, arthrosis) and spine (eg, ankylosing spondylitis
Ankylosing spondylitis - a lot of patience is required
, Scoliosis), which are accompanied by severe pain. It is used for a long time as part of combination therapy. Helps Nise and in pain at other sites - dental, ear, head, pain during menstruation.
Contraindications for receiving Naiza
Nise has many contraindications - mainly diseases of the organs to which it has a negative effect: stomach ulcers and gastritis, severe liver disease in violation of its function, increased bleeding. It is not recommended to use it also at individual intolerance, pregnancy, during lactation and children under 12 years.
At the same target organs extends side effects of the drug. In some patients, it causes nausea, vomiting, abdominal pain
Abdominal pain: Types and Symptoms
, Abnormal liver function, bleeding, anemia, decreased immunity.
Nise - attorney time a drug that causes far fewer complications than traditional NSAIDs.