Dekaris - instructions to the drug's manufacturer, reflects only its anthelmintic properties. However, dekaris is also an immunostimulant, which some time ago was actively used for the correction of immunodeficiency states. Today, as the use of decaris immunostimulant limited.
The mechanism of action decaris
Dekaris (active substance - levamisole) produces the Hungarian pharmaceutical company Gedeon Richter in tablets of 50 and 150 mg. Excipients are corn starch, sodium saccharin, talcum, povidone, apricot flavor, magnesium stearate, sunset yellow dye.
In accordance with the instruction is dekaris anthelmintic drug. He actively affects the nervous system of roundworms (nematodes), causing paralysis of the neuromuscular system. Furthermore, blocking the action of certain enzymes (succinate dehydrogenase and fumaratdegidrogenazy), he breaks the cellular metabolism
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nematodes. Paralyzed worms are removed from the body with feces as a result of intestinal motility within days after taking decaris
Dekaris - with anthelmintic drug and immunostimulatory effects
As immunostimulant enhances the activity of T-lymphocytes (stimulate cell-mediated immunity) for the production of antibodies (humoral immunity) is not affected. But the immunostimulatory effect of this drug is negligible. Given the presence of a large number of side effects such as an immune stimulant used today dekaris rare.
When administered dekaris rapidly absorbed from the gastrointestinal tract and into the bloodstream where it is determined by the maximum concentration two hours after ingestion. Later active substance decaris levamisole decomposed in the liver and then excreted as metabolites in the urine. In unaltered dekaris released in small amounts in the urine and feces.
Indications and contraindications for use decaris
Dekaris used to treat helminth infections caused by roundworms (nematodes): ascariasis, necatoriasis, strongyloidiasis, trihostrongiloidoza, hookworm, toxocariasis.
Dekaris contraindicated in case of hypersensitivity of the body to the components of the drug, previously develops due to medication agranulocytosis (a sharp decrease or even complete absence of granular white blood cells responsible for cell-mediated immunity), while feeding the baby
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feeding. Tablets 50 mg are not indicated for children up to three years, and the tablets of 150 mg - the children of any age.
With caution and only the testimony of life dekaris used during pregnancy, as well as in severe liver and kidney diseases and disorders of hematopoiesis.
Caution should be observed during the application decaris with drugs affecting blood, with some types of anticoagulants (lowering of blood clotting) and drugs such as chloroform or ether, as its toxicity may increase.
When a single application decaris in recommended doses side effects usually do not happen. But long-term use or use at high doses may cause headaches, dizziness, sleep disturbances
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, Palpitations, cramps, nausea, vomiting, diarrhea, abdominal pain.
Sometimes side effects occur in the central nervous system in the form of encephalopathy approximately one month after receiving decaris. Perhaps the emergence of allergic reactions and exacerbation of chronic skin diseases (eg psoriasis).
It is also possible negative effects on hematopoietic system decaris up to agranulocytosis.
During and after taking the drug during the day can not drink alcohol: development disulfiramopodobnyh reactions in the form of facial flushing, abdominal cramping and stomach, nausea, vomiting, headache, a sharp decline in blood pressure, etc. This reaction develops due to the fact that dekaris (as well as disulfiram or teturam) inhibits the decomposition and excretion of alcohol.
Do not sit behind the wheel of a car after taking decaris as one of the side effects of this drug can be dizziness.
Is it possible to overdose decaris?
Overdosing is possible when receiving decaris adult four or more tablets of 150 mg. At the same time a person has nausea, vomiting, diarrhea, headache, dizziness, sleepiness, convulsions, confusion.
First aid in case of overdose: gastric lavage. It should also immediately call an ambulance.