Duspatalin available in capsules prolonged (longer) acts for ingestion. A feature of this formulation is the gradual release of the active principle and its long-term effect on the body. In order to ensure a constant therapeutic effect dyufastalin sufficiently taken twice a day (morning and evening).

Structure and mechanism of action of the capsules dyufastalina

The composition of the capsules depot dyufastalin includes active substance (mebeverine) and adjuvants - magnesium stearate, methyl methacrylate-ethyl acrylate copolymer, talc, hypromellose, methacrylic acid-ethacrylate, triacetin. The composition of the capsule shell comprises gelatin, and titanium dioxide.

Each capsule contains 200 mg Duspatalin mebeverina. After absorption in the gastrointestinal tract mebeverin the bloodstream to the liver, where it is first decomposed into metabolites (products of metabolism) to veratric mebeverinovogo acid and alcohol. Further mebeverina decomposition also occurs in the liver. Once in the blood and effects on the smooth muscles of the digestive system mebeverina metabolites excreted in the urine. A number of metabolites mebeverina is also displayed in the bile.

This gradual expansion of the liver mebeverina provides long-term supply of active substances in the blood and their effect on the smooth muscles of the digestive system. The duration of action of the drug is 16 hours, so taking two capsules a day (morning and evening) provide its continuous therapeutic effect.

Therapeutic effect Duspatalin is that it removes quickly and effectively for a long time, a spasm of smooth muscles of the digestive system. But it does not inhibit the normal intestinal peristalsis, bile ducts, and pancreatic ducts Diabetes and pancreas - the things you need to know That allows these organs to function normally. Duspatalin non-toxic drug, it has almost no contraindications for the appointment, and side effects.

In some cases, prescribe Duspatalin

Indications for use Duspatalin is any disease of the digestive system, accompanied by spasms and pain. First of all, it cramps and pain in the gastrointestinal tract, which develop in various diseases and conditions of the stomach and intestine: chronic gastritis, gastro, gastric ulcer and duodenal ulcers, various poisoning, intoxications, intestinal infections, and so on.

In all these diseases, as well as goiter, which is accompanied by digestive problems and intestinal colic, Duspatalin relieve cramps, pain and restore normal blood circulation in the walls of the gastrointestinal tract. He did not suppress intestinal motility and passage of stool will break through the intestines.

Very frequent in recent years has become intestinal dysbiosis Intestinal dysbiosis - how dangerous it is?   (violation of the relationship between the normal and the pathogenic microflora of the intestine), which is largely due to the uncontrolled use of antibiotics Antibiotics - whether they will help you in the foreseeable future? . The suppression of normal intestinal microflora leads to the wrong digestion. In the process of digestion formed many gases and toxic substances, which leads to intestinal colic. Duspatalin helps to relieve intestinal colic, without inhibiting the process of removing feces and toxins from the body.

In diseases of the liver and biliary tract Duspatalin helps relieve cramps, colic and restore normal excretion of bile into the duodenum. This allows you to use this medication at the intra- and extrahepatic bile stasis, inflammatory processes in the bile ducts and gall bladder.

In diseases of the pancreas Duspatalin is of particular importance, as it helps rid the ductal pancreatic juice. This prevents the development of severe disease such as acute pancreatitis and pankreanekroz - autodigestion pancreatic tissue using its own enzymes contained in pancreatic juice.

Side effects and contraindications

Duspatalin virtually no side effects but allergic reactions Allergic reactions: how to understand why you tickle in the throat Which require discontinuation.

Duspatalin contraindicated if you are hypersensitive components of the drug by the body of the patient, at the age of 18 years (not conducted clinical trials in children) and lactation (no reliable data on the allocation of the drug to human milk). With caution and only life Duspatalin indications prescribed during pregnancy.

Galina Romanenko

Kvamatel - a drug that has anti-ulcer action as suppresses gastric acid secretion. It is widely used for stomach ulcers and duodenal ulcers, as well as some other diseases of the digestive system.

As kvamatel acts on the stomach

Peptic ulcer and duodenal ulcer develops under the influence of increased acidity of gastric juice. A large amount of hydrochloric acid in gastric juice causes gastritis, esophagitis (inflammation of the esophagus that occurs due to the abandonment into the esophagus acidic stomach contents), duodenitis (inflammation of the duodenum), and a negative impact on the state of the liver and pancreas Diabetes and pancreas - the things you need to know .

It stimulates the secretion of gastric juice, including hydrochloric acid, a biologically active substance histamine: on the surface of secreting cells of the stomach have molecules - receptors, having an affinity for the histamine called H2 histamine receptors (H1 receptors are located in the bronchi and blood vessels and are responsible for the development of allergic reactions).

In order to prevent the increased secretion of gastric acid, drugs are used, which are called histamine H2-receptor blockers. One such drug is kvamatel.

Kvamatel peculiarity is that it not only blocks histamine H2 receptors, but also has an active effect on gastric mucus, increasing its number and its content of different protective substances. Such protective substances are, e.g., prostaglandins, which are always contained in the gastric mucosa and protect it from any external influences. For example, when administration of nonsteroidal anti-inflammatory drugs (NSAIDs, such as diclofenac) inhibited the activity of prostaglandins, which could lead to the formation of stomach ulcers. Prostaglandins also promote rapid scarring.

This shows the use of

Apply kvamatel only on prescription after a preliminary examination, and further diagnosis. The main indication for the use of this drug is a gastric ulcer and duodenal ulcer. This eliminates the annoying kvamatel mucosa factor that increases its defense and promotes rapid scarring ulcers. It will kvamalel and erosive and ulcerative lesions of the stomach and duodenum caused by stress and NSAIDS.

In some cases, ulceration of the gastric mucosa yet, but inflammation in the stomach irritation constantly maintained its walls gastric juice acidity. This disease is called giperatsidnym gastritis and also requires the suppression of gastric acid secretion.

The acidic contents of the stomach may be bombarded with the esophagus, causing irritation of its walls (reflux esophagitis). May enter the gastric juice into the duodenum, causing its damage, and inflammation. In all these cases kvamatel will bring significant relief to patients.

The stomach and duodenum may suffer and adenoma (a benign tumor of glandular tissue) of the pancreas. In the pancreatic juice contains a large amount of gastrin hormone which stimulates gastric acid secretion. As a result, developing Zollinger-Ellison syndrome - ulcerative lesion of the gastric mucosa and duodenal ulcers. Kvamatel prevents the development of this syndrome.

Finally, kvamatel prescribed as part of a complex of anti-treatment for the prevention of any exacerbation of digestive diseases associated with increased gastric secretion. Cancel kvamatel gradually, as the sudden interruption of its reception may develop withdrawal symptoms.

When kvamalel contraindicated, and whether he has side effects

Kvamatel has few contraindications. It can not be used during pregnancy and nursing Breastfeeding - a personal choice   feeding, in children and patients are hypersensitive to the components of the drug. Precautions kvamatel prescribed for severe liver and kidney diseases in violation of their functions.

Kvamatel has a number of side effects that occur relatively seldom, however, need to know about them. This loss of appetite, dry mouth, nausea, vomiting, stomach pain, bloating, constipation, diarrhea, transient liver dysfunction, acute pancreatitis. Changes in the blood can cause a decrease in immunity and the threat of bleeding, and on the part of the cardiovascular system - heart rate arrhythmia, cardiac blockade and reduction in blood pressure. May worry as headache, dizziness, lethargy, drowsiness, hallucinations, confusion, decreased vision and hearing, hormonal disorders (male of female type changes in women - menstrual disorders), pain in joints Joint pain - how to understand what is going on?   and muscles, acne Acne: facial trouble , Alopecia, allergic reactions.

Kvamatel - quality medicines, which produces well-known pharmaceutical company Gedeon Richter (Hungary).

Galina Romanenko