By means of modern anti-ulcer is omeprazole. Description omeprazole reveals the mechanism of action of proton pump inhibitors (pump). Drugs of this series of actions at the cellular level, so were synthesized relatively recently - in the mid-70s of the last century.
What is a proton pump (or pump) and how it works
Hydrochloric acid is produced by cells in the stomach glands located in the mucosa. In each cell, "is" proton pump opening into the gastric lumen. This name received enzyme hydrogen- potassium adenosinetriphosphatase (abbreviated - H + / K + -ATPase), as it is using the energy derived from the decomposition of ATP forcibly bypassing normal ion transport channels of the cell and into the cell, transports the hydrogen ions out of the cell into the gastric lumen, taking out the potassium ions. Potassium from the cell then exits too, but not one, but with chloride ions and through the usual transport routes. Thus, in the lumen of the stomach appear hydrogen ions and chlorine, which combine to form hydrochloric acid.
How does Omeprazole
The first omeprazole (the original drug) was synthesized in the Swedish pharmaceutical company AstraZeneca about forty years ago, and sold under the trade name losek. Today, omeprazole produced many drug companies under their own brand names - such drugs are called generics. Many generics in its quality as the original drug loseku, but are much cheaper.
The mechanism of action of omeprazole is associated with an inhibition (suppression) of the enzyme H + / K + -ATPase (proton pump) - it loses its ability to transport the desired acid to produce the salt ions, which leads to a suppression of gastric acid secretion and reduce gastric acidity.
In addition, omeprazole inhibits the vital functions of the infectious agent responsible for the development of gastric ulcer and duodenal ulcers (Helicobacter pylori). This occurs due to the fact that gastric acidity drastically lowered, and in such a medium Helicobacter pylori can not exist.
When making omeprazole into tablets or capsules quickly and adequately absorbed into the blood and into the stomach tissue. Its action comes after about an hour, two hours later, the peak of the action, within days the secretion of gastric juice is suppressed by half. The drug works best if it is taken as a course of treatment - it increases efficiency and is maximized by the fourth day. After treatment the therapeutic effect lasts for 3-5 days. When you remove the drug stimulating the secretion of hydrochloric acid does not occur.
Displayed omeprazole primarily through the kidneys, a much smaller part - in the bile and feces. Before Withdrawal decomposed in the liver to neutral metabolic products (metabolites). When violations of the kidneys and liver, as well as in the elderly absorption of omeprazole can be increased, but at the same time removing it from the body slows down.
In some cases, appointed
Omeprazole administered in the complex treatment and prevention of relapse in many diseases of the gastrointestinal tract that are accompanied by increased acidity of gastric juice.
Such diseases especially true gastric ulcer and duodenal ulcer. Omeprazole is especially effective in detecting the infectious agent such as Helicobacter pylori. Rapid and significant increase in the stomach Ph (ie decrease in acidity) contributes to the suppression of life, and Helicobacter pylori creates an environment favorable to the action of antibiotics. Assign omeprazole well as erosive and ulcerative processes in the stomach caused by stress and certain medications (aspirin, ibuprofen
Ibuprofen: anti-inflammatory drug
In inflammatory processes in the esophagus associated with throwing it acidic gastric contents, as well to omeprazole. Description of the beneficial effects of this drug when reflux esophagitis is found in the works of many domestic and foreign researchers.
Apply omeprazole as diseases of other digestive organs, which are accompanied by high acidity of gastric juice, such as Zollinger-Ellison syndrome - a benign tumor
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Who should not take omeprazole
Omeprazole is a non-toxic drug, it is usually well tolerated by patients, so has few contraindications. Do not take omeprazole hypersensitivity to him the body of the patient, as a child, when feeding the baby
Breastfeeding - a personal choice
breast and liver dysfunction.
But omeprazole has a number of side effects, take into account possible effects on the patient's doctor can only. With extreme caution, and only on the testimony of omeprazole are encouraged to nominate during pregnancy, impaired renal function and in the elderly.