Pancreatin - a drug, which comprises pancreatic enzymes involved in the digestion of food. It also stimulates the secretion of their digestive enzymes of the gastrointestinal tract, which allows the use of this drug in many diseases of the digestive organs, and also at reception of a fat and indigestible food healthy people.
The mechanism of action of pancreatin
Pancreatin is obtained from the pancreas of pigs and cattle. It consists of the enzymes amylase (digests carbohydrates) lipase (digests fats), proteases (digested carbohydrates). Various pharmaceutical companies Pancreatinum issued in the form of tablets, capsules and pills under the names: bios, Vestal, gastenorm, Zimet, Creon
Creon - medicine to help digestion
, Likreaza, mezim, mikrazim, pangrol, Panzi, panzinorm, pankreazim, pankrealipaza, pankreal, pankrenorm, pankreon, pantsitrat, penzital, prolipaza, triferment, festal, enzistal, ermital.
All these preparations may contain both pure pancreatin, and various additives as cholic acid, a choleretic agent and so on.
Moreover, formulations containing pancreatin may be divided according to particle size active principle to conventional tablets, pills or capsules, enteric coated, which allows the drug to dissolve in duodenum (in the acidic environment of the stomach pancreatin loses its properties) and mini granule form. Microgranular form (e.g., Creon) are gelatin capsules inside of which are acid-balls with a diameter of less than 2 mm - it provides for the simultaneous delivery of the drug with food into the duodenum.
The instructions to the drug, containing pancreatin, must indicate the activity of its constituent enzymes - amylase, lipase and protease (it can be different).
The mechanism of action of pancreatin based on the fact that its constituent pancreatic enzymes (lipase, alpha-amylase, trypsin, chymotrypsin) degrade proteins into amino acids, fats - to glycerol
Glycerine: a miracle ingredient for skin and hair
fatty acids, carbohydrates - to simple sugars. It uluchaet digestion process as a whole (including the digestion of food), removes the burden from the gastrointestinal tract and improves their functional condition. In various diseases of the pancreas dysfunction of preparations containing pancreatin, compensates for the lack of secretion of digestive juices and stimulate the secretion of pancreatic enzymes own. In addition, they stimulate the secretion of enzymes of the stomach, small intestine and bile.
Indications and contraindications
Pancreatin is used in many diseases of the digestive organs, which are accompanied by a violation of the process of digestion:
- in cases involving a decrease in the secretion of digestive enzymes of the pancreas - cystic fibrosis and chronic pancreatitis;
- in cases involving a decrease in the secretion of digestive enzymes of the stomach, intestines, liver;
- to improve food digestion in people with normal function of the digestive system in the use of fat, indigestible food, abuse of the process of chewing or with a long stay in a forced position when disturbed motor activity of the intestine;
- to reduce gas formation in preparation for X-ray and ultrasonography of the stomach, intestines and other abdominal organs.
The use of pancreatin contraindicated if you are hypersensitive its components, as well as in acute diseases of the digestive system - acute pancreatitis, exacerbation of chronic pancreatitis, acute hepatitis
Acute hepatitis - always seriously
and intestinal obstruction.
Pancreatin has no teratogenic (fetal anomalies) action, however, it is recommended that pregnant women be used with caution, as the full clinical trials in pregnant women the drug have been conducted. With care it is used and during breast
Breastfeeding - a personal choice
Pancreatin very rarely has side effects, however, they need to know, because this drug, patients often take their own without a doctor's prescription. So, from the gastrointestinal tract pancreatin may cause constipation (often) or diarrhea, nausea, discomfort in the stomach. In children with prolonged use of pancreatin possible skin irritation around the anus.
From a metabolism during long-term use at high doses may increase the levels of uric acid in the blood.
Possible allergic reactions such as skin rash, hives, sneezing and watery eyes.