Pancreatin - a drug, which comprises pancreatic enzymes involved in the digestion of food. It also stimulates the secretion of their digestive enzymes of the gastrointestinal tract, which allows the use of this drug in many diseases of the digestive organs, and also at reception of a fat and indigestible food healthy people.

The mechanism of action of pancreatin

Pancreatin is obtained from the pancreas of pigs and cattle. It consists of the enzymes amylase (digests carbohydrates) lipase (digests fats), proteases (digested carbohydrates). Various pharmaceutical companies Pancreatinum issued in the form of tablets, capsules and pills under the names: bios, Vestal, gastenorm, Zimet, Creon Creon - medicine to help digestion , Likreaza, mezim, mikrazim, pangrol, Panzi, panzinorm, pankreazim, pankrealipaza, pankreal, pankrenorm, pankreon, pantsitrat, penzital, prolipaza, triferment, festal, enzistal, ermital.

All these preparations may contain both pure pancreatin, and various additives as cholic acid, a choleretic agent and so on.

Moreover, formulations containing pancreatin may be divided according to particle size active principle to conventional tablets, pills or capsules, enteric coated, which allows the drug to dissolve in duodenum (in the acidic environment of the stomach pancreatin loses its properties) and mini granule form. Microgranular form (e.g., Creon) are gelatin capsules inside of which are acid-balls with a diameter of less than 2 mm - it provides for the simultaneous delivery of the drug with food into the duodenum.

The instructions to the drug, containing pancreatin, must indicate the activity of its constituent enzymes - amylase, lipase and protease (it can be different).

The mechanism of action of pancreatin based on the fact that its constituent pancreatic enzymes (lipase, alpha-amylase, trypsin, chymotrypsin) degrade proteins into amino acids, fats - to glycerol Glycerine: a miracle ingredient for skin and hair   fatty acids, carbohydrates - to simple sugars. It uluchaet digestion process as a whole (including the digestion of food), removes the burden from the gastrointestinal tract and improves their functional condition. In various diseases of the pancreas dysfunction of preparations containing pancreatin, compensates for the lack of secretion of digestive juices and stimulate the secretion of pancreatic enzymes own. In addition, they stimulate the secretion of enzymes of the stomach, small intestine and bile.

Indications and contraindications

Pancreatin is used in many diseases of the digestive organs, which are accompanied by a violation of the process of digestion:

• in cases involving a decrease in the secretion of digestive enzymes of the pancreas - cystic fibrosis and chronic pancreatitis;
• in cases involving a decrease in the secretion of digestive enzymes of the stomach, intestines, liver;
• to improve food digestion in people with normal function of the digestive system in the use of fat, indigestible food, abuse of the process of chewing or with a long stay in a forced position when disturbed motor activity of the intestine;
• to reduce gas formation in preparation for X-ray and ultrasonography of the stomach, intestines and other abdominal organs.

The use of pancreatin contraindicated if you are hypersensitive its components, as well as in acute diseases of the digestive system - acute pancreatitis, exacerbation of chronic pancreatitis, acute hepatitis Acute hepatitis - always seriously   and intestinal obstruction.

Pancreatin has no teratogenic (fetal anomalies) action, however, it is recommended that pregnant women be used with caution, as the full clinical trials in pregnant women the drug have been conducted. With care it is used and during breast Breastfeeding - a personal choice   feeding.

Side effects

Pancreatin very rarely has side effects, however, they need to know, because this drug, patients often take their own without a doctor's prescription. So, from the gastrointestinal tract pancreatin may cause constipation (often) or diarrhea, nausea, discomfort in the stomach. In children with prolonged use of pancreatin possible skin irritation around the anus.

From a metabolism during long-term use at high doses may increase the levels of uric acid in the blood.

Possible allergic reactions such as skin rash, hives, sneezing and watery eyes.

Galina Romanenko

Phosphogliv tablets (correctly, in capsules) for oral administration often administered after treatment phosphogliv Phosphogliv - advanced analogue esseniale   by intravenous injection and can last for a long time without any adverse effects. Apply this drug for many diseases of the liver, as well as other diseases of the digestive system, skin, atherosclerosis Atherosclerosis - a chronic disease of the arteries   and so on.

How do the pills phosphogliv

Phosphogliv available in capsules, each capsule in the composition consists of 65 mg of phospholipids and 35 mg of sodium glycyrrhizinate. Together, these two substances are mutually reinforce and complement each other's action.

The main active ingredient is the phospholipid phosphatidylcholine, it is up to 73-79% of all members of the capsules of phospholipids. This substance is a natural component of membranes and intracellular inclusions of some liver cells (hepatocytes). Liver cells can suffer in various viral infections, metabolic and allergic processes, poisoning by toxic substances.

Additionally, entering the body of the patient in capsules restores phosphatidylcholine (stabilizes cell membranes, and they do not allow certain enzymes and other active substances to leave the liver cells. This allows you to save normal metabolism Improves metabolism and losing weight without dieting   cells (protein, fat reserves energetic material - carbohydrates in the form of glycogen) and to maintain their normal function, particularly, disintoxication (cleansing the blood of toxins). The phospholipids also suppress the growth of connective tissue in the liver, thereby preventing the development of cirrhosis and reduced liver function.

Another component phosphogliv capsules - sodium glycyrrhizinate (glitsirat) complements the action of phospholipid-inflammatory, anti-allergic and anti-viral action. Anti-inflammatory and anti-allergic effect glitsirata due to the intensification of action of glucocorticosteroids (GCS), produced by the adrenal glands (which SCS is the most potent anti-inflammatory and antiallergic).

Antiviral action glycerate stimulation occurs when the child's education in hepatocytes interferon antiviral agents, as well as stimulation of phagocytosis - the entrainment and dissolution of immune cells viruses. Glycerate also enhances the inhibitory effect of phospholipids on proliferation of connective tissue.

The combined effects of components phosphogliv reduces atherosclerosis manifestations: it reduces its concentration in the blood and deposition of atherosclerotic plaque in blood vessels.

Phosphogliv a positive effect on the skin and in chronic inflammatory and allergic processes. It stabilizes the membranes of skin cells, suppresses inflammatory and allergic processes, prevents the spread of the process.

Which diseases appoint phosphogliv

Capsules phosphogliv prescribed for any liver disease. The only exceptions are diseases that are accompanied by increased pressure in the veins of the liver - portal hypertension Hypertension - Control your blood pressure .

In acute inflammatory processes of viral origin (hepatitis A) phosphogliv are beginning to be used in the form of an intravenous injection, and later move on to maintenance therapy - ingesting capsules phosphogliv. The duration of the total course of treatment is usually from one to three months, depending on the patient's general condition. In acute hepatitis, such treatments contribute to a more rapid removal from the body of pathogens, accelerate the process of stabilization of the patient, recovery of liver function and prevent the development of cirrhosis with extensive necrosis of hepatocytes.

In chronic inflammation of the liver (chronic hepatitis B, C, D) phosphogliv appointed a longer course of treatment - not less than six months. Such treatments stop the recurrence of the disease, contribute to a more long-term remission and prevent the gradual widening of the connective tissue with the formation of cirrhosis.

Apply phosphogliv capsules and when exchange, allergic diseases and intoxications that inhibit the function of hepatocytes.

In addition, this drug is used in the complex treatment of allergic and chronic inflammatory (including autoimmune, allergic to its own tissues) skin diseases - eczema, neurodermatitis, psoriasis and so forth.

Recently phosphogliv increasingly include in the comprehensive treatment of atherosclerosis and diseases that develop on the background - coronary heart disease, stroke, impaired patency of peripheral blood vessels.

Phosphogliv capsules for oral administration - a non-toxic drug that almost no side effects, and has very few contraindications for use.

Galina Romanenko