Buserelin spray - a medicament for intranasal (in the nasal cavity) application. It is widely used for the treatment of hormone-dependent diseases such as endometrial hyperplasia of the uterus and endometriosis. These diseases develop when excess levels of female sex hormones estrogen. Buserelin spray suppresses ovarian function, which contributes to the spread of the suspension of the pathological process.

Buserelin spray - especially actions

Buserelin nasal spray belongs to the group of agonists (analogues) of gonadotropin-releasing hormone from the hypothalamus (GnRH). Under the influence of this hormone in the blood increases the content of the beginning of the pituitary gonadotropins (TG), the latter also stimulates the synthesis of hormones. But after some time (about two weeks) begins a backlash: a large number of sex hormone inhibits the secretion of TG, and the absence of TG completely inhibits the function of the ovaries. Thus, there comes the state of medical castration. This state has a positive effect on the course of any hormone-dependent diseases of the reproductive organs.

When endonasal application buserelin spray almost completely absorbed through the nasal mucosa and into the bloodstream. Besides the main active ingredient in the spray composition includes adjuvants - benzalkonium chloride and water for injection. Each vial contained 17 ml of 5 spray, 1 ml of which contains a metered dose of 0, 15 mg of active principle.

Buserelin in dosage form of a nasal spray is used mainly for the treatment of hormone-dependent diseases and benign tumors of the reproductive system. For the treatment of malignant tumors of different formulation applied buserelin - buserelin-depot.

To whom and how administered buserelin spray

Buserelin spray is used only on prescription in the hormone-dependent diseases and benign tumors of the female genital organs, resulting in an excess in women estrogen female sex hormones: endometriosis, endometrial hyperplasia of the uterus, uterine fibroids. In these diseases, the daily dose of buserelin spray 900 mcg. The daily dose is divided into three and applied at 300 micrograms three times a day at intervals of 6-8 hours. Thus injecting into one nostril to 150 micrograms in two nostrils - 300 micrograms. Initiation of treatment should be the first day of the menstrual cycle The days of the menstrual cycle: Four phases   (ie the first day of menstruation).

Buserelin spray applied as in vitro fertilization (IVF). In this case it is administered in multiple smaller doses - 600 .mu.g or one injection four times per day. This allows you to slow down ovarian function, but does not disable it completely to the ovaries could "respond to" the production of hormones in response to their artificial stimulation of the pituitary THG. This creates a controlled menstrual cycle, allowing to remove ripe egg from the ovary, fertilizing her husband's sperm in a test tube, and after some time to introduce the embryo into the uterus of a woman.

Contraindications and possible overdose

Application buserelin spray is contraindicated during pregnancy, infant feeding Breastfeeding - a personal choice   breasts and hypersensitive to the components prepvrata woman's body.

An overdose of this medication is not seen, because without a doctor it does not apply.

Side effects

The worst side effect of this drug may be changes in the central nervous system in the form of headaches, sleep disorders Dreams: how to understand our dreams   and changeable moods, sometimes rolling in depression Depression - a little more than a bad mood . Depression - a dangerous mental condition which requires constant medical supervision.

At the beginning of the treatment under the influence of a large number of sex hormones may develop ovarian cysts. Therefore, if a woman, for whatever reason, need a second course of treatment, should first take her full inspection. Sometimes early treatment can occur menstrualnopodobnye bleeding. When secretion of female hormones to be completely suppressed, there is the development of osteoporosis - calcium deficiency in the bone (this is derived from the lack of estrogen), which leads to bone fragility and fractures frequently. Therefore, long-term treatment with GnRH analogues are usually not carried out.

The lack of female sex hormones also leads to vaginal dryness, decreased libido, sweating, typical appearance of "menopausal catches" sketch to the face and upper body.

It is also possible occurrence of allergic reactions such as urticaria or angioedema.

Burselerin spray is never used without a doctor's prescription.

Galina Romanenko

Hormone-dependent tumors of the reproductive system today is often treated using analogs of hormones of the hypothalamus. The group of these drugs include domestic product buserelin. Action buserelin associated with complete suppression of ovarian function - it stopped producing sex hormones and hence stimulate tumor growth.

How to regulate the function of the human reproductive system

Jobs sexual organs and reproductive (fertility) function is controlled by the neurohormonal system, which consists of: the hypothalamus (a brain region responsible for the operation of the whole endocrine system), the pituitary gland (the main endocrine glands, responsible for the regulation of secretion of all other glands) and gonads (ovaries in women and testes in men).

The secretion of pituitary gonadotropins (TG) is regulated by the hypothalamic releasing hormones, such as stimulating the secretion of gonadotropin-TG is carried Riesling-hormone (GnRH). In turn, the State Tretyakov Gallery, the pituitary regulates the secretion of hormones by the ovaries or testes. This is a direct effect of neurohormonal system regulating reproductive function. There is also the opposite effect: increased blood levels of sex hormones inhibits the secretion of pituitary THG.

These properties of the neurohormonal system based action of modern hormonal drugs - agonists (analogues) Riesling-gonadotropin-releasing hormone (GnRH). The group of these drugs include buserelin.

Buserelin - gormonozavivimyh effect in diseases of the reproductive system of women

Buserelin used in diseases and tumors of female reproductive system, are associated with increased blood levels of female sex hormones. These are some types of cancer, breast cancer, uterine fibroids, endometrial hyperplasia Hyperplasia endometrial cancer - requires timely detection and treatment   uterus, endometriosis.

When breast cancer hormone-suppression buserelin Buserelin - helps cancer   secretion of female hormones (mainly estrogen) often results in tumor growth arrest. Therefore, buserelin is often used after surgery, chemotherapy replacing.

Uterine endometrial hyperplasia (excessive growth of the inner mucosal layer of the uterus) is also associated with increased secretion of estrogen. The suppression of estrogen secretion stops the process of proliferation of the mucous membrane.

Since the disease is closely related to other disease - endometriosis, when the background of mucosal hyperplasia its rejection mucous particles fall into other organs and tissues, proliferate there, and also undergo cyclic changes under the action of hormones. Introduction buserelina before and after surgery can permanently stop the spread endometriorza.

In benign tumors of the uterus - uterine growth is also closely associated with the female sex hormones, buserelin almost always include in the comprehensive treatment of this disease.

Buserelin is used as in vitro fertilization (IVF) to suppress ovarian function and create a managed menstrual cycle.

Women on treatment with buserelin often have headaches, mood disorders (up to depression), sometimes - nausea, vomiting and diarrhea.

Buserelin - effect in hormone-dependent diseases of the male reproductive system

Buserelin used in the treatment of prostate cancer, the growth of which is closely associated with excess hormones. Inhibition of secretion of sex hormones not only stops the growth of tumors, but also causes an improvement of the patient because it reduces the swelling of the prostate gland, which led to compression of the surrounding tissue, in particular to compression of the urinary tract and urinary disorders.

But in the first two weeks after the start of treatment patient's condition may deteriorate due to the fact that the first buserelin stimulates the secretion of hormones that leads to swelling of the prostate tissue and bladder significantly disturbed. Just two weeks after the start of treatment starts feedback and secretion of sex hormones is completely suppressed and the patient's condition improved significantly. But almost completely disappears libido.

Against the background of the introduction of buserelin in men can also occur headaches and depression Depression - a little more than a bad mood But these side effects are they less often than women.

When buserelin can not be used

Buserelin - is an effective and non-toxic drug, it gives few side effects and has few contraindications for use. Do not use buserelin only if you are hypersensitive to the components of this drug during pregnancy and nursing Breastfeeding - a personal choice   feeding. Be wary of this drug is indicated for severe depression.

Galina Romanenko