Treatment of adenomyosis quite long and complicated process. In the treatment of internal endometriosis used two ways: surgical removal of endometriosis and the appointment of hormonal drugs. Before you choose one or another method of treatment, the woman should be examined in order to establish an accurate diagnosis and the severity of the disease. Hormone treatment of adenomyosis is conducted for all patients, regardless of their age and lack of evidence or for surgery. In addition to the appointment of hormonal drugs for adenomyosis, held immunokorrigirujushchaja and symptomatic therapy.

Hormonal treatment of the disease in each case carried out individually and depends on many factors (the patient's age, marital status, interest in the pregnancy, the severity of adenomyosis and endometrial foci sensitivity to hormonal drugs).

Apply these hormones when adenomyosis:

• Estrogen-progestin oral contraceptives

The mechanism of action of estrogen-progestin drugs (for the treatment of adenomyosis Adenomyosis - treatment should be individualized   monophasic contraceptive use) associated with the suppression of the formation of gonadotropin-releasing factor. The resulting cyclic inhibited secretion of FSH (follicle stimulating hormone) and LH (luteinising hormone). Thus formed anovulatory cycles. While taking estrogen-progestin preparations ovaries decrease in size, contain more atrezirovannyh follicles and characterized by changes inherent to premenopausal Premenopausal women - one step in a woman's life .

• Derivatives of 19-nortestosterone

Derivatives 19 nortestesterona or progestins are associated with estrogen Estrogen - the key to bone health - And progesterogenovymi receptors in target tissues, and thus free to androgen receptors, i.e. have antiprogesteronovoe and antiestrogenic action. Progestogen dose depends on the severity and the type adenomyosis medicament. Didrogesteron, lynestrenol, norethisterone acetate administered at 5-10 mg per day from the fifth to the twenty-fifth day of the menstrual cycle The days of the menstrual cycle: Four phases   within three to six months.

• Antiprogestins

A relatively new drug that is used for the treatment of adenomyosis is Gestrinone. The drug has anti-estrogenic and androgenic effects, suppresses the growth of follicles, leading to inhibition of estrogen production. Gestrinone administered in a dose of 2, 5-5 mg twice a week.

• Antiestrogens

For drugs group antiestrogens include tamoxifen. Tamoxifen - a non-steroidal compound that has agonistic and antigonisticheskim actions in relation to estrogens. The drug blocks estrogen-dependent receptors in target cells and inhibits the synthesis of prostaglandins, which are responsible for the growth and maturation of follicles. Assigned Tamoxifen at a dose of 10 mg twice a day for six months.

• Inhibitors of gonadotropins

Drugs in this group is Danazol. Danazol is a synthetic steroid, has an active gonadotropin action and deprived of estrogen and progestogen properties, and has a moderate androgenic influence. The mechanism of action of the drug associated with the suppression of secretion of LH and FSH from the pituitary gland, resulting in inhibited secretion of ovarian hormones. Furthermore, Danazol affects the immune system of patients with adenomyosis, reduces the concentration of autoantibodies. Effective therapeutic doses are in the range of 200 - 800 mg per day. Adenomyosis recommended to begin treatment with 400 mg a day, and then, depending on the results of the dose or increase or decrease. Side effects caused by androgen danazol influence.

• Agonists of gonadotropin-releasing hormone

The use of drugs of this group (Zoladex, Dekapetil, Sinarel) leads to the development of drug "castration." In the treatment of relatively high frequency of side effects. These include weight gain, hot flashes, loss of libido and vaginal dryness. Zoladex available in capsules. One capsule, containing 3, 6 mg of material injected subcutaneously one time in 28 days.

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Diflucan can be taken with food or on their own, at any time of the day. Typically, for a full treatment of fungal infection takes a few days - even though symptoms of fungal disease may disappear in the first twenty-four hours after taking Diflucan, to ensure successful treatment may require prolonged drug.

Diflucan (active ingredient - fluconazole) - antifungal agent from the group of synthetic triazole. The main indications for the reception of the drug:

• Genital candidiasis (yeast infection of the vagina caused by a fungus Candida, women and balanitis, an inflammation of the glans penis in men).
• Oropharyngeal and esophageal candidiasis (a fungal colonies esophagus and pharynx), as well as fungal infections of the urinary tract, abdomen.
• Systemic candidiasis (including candidemia, disseminated candidiasis).
• Cryptococcal meningitis Meningitis - an inflammation of the meninges .

Furthermore, Diflucan can be used for preventing fungal diseases where the immune system has been weakened by some treatments (such as chemotherapy Chemotherapy - it always falls the hair?   or radiotherapy), and there is a risk of the disease return.

Possible side effects of Diflucan

Stop taking the drug is necessary for detecting the first signs of an allergic reaction - skin rash, difficulty breathing, swelling of the face, lips, tongue and throat. When the following side effects of Diflucan need to seek medical help:

• Nausea, abdominal pain, fever, loss of appetite, change in urine color to a darker, jaundice (yellowing of the skin or eyes);
• Fever, chills, body aches, symptoms of a cold / flu;
• Red, scaly skin rash on the skin;
• Atypical weakness, constant bruising, poor blood clotting

The dosage of the drug for adults

• One dose

Vaginal candidiasis (thrush)

The recommended dose for the treatment of thrush Diflucan Treating Thrush: how to get rid of bad fungus   - One hundred and fifty milligrams of the drug once orally.

• Multiple doses

Because Diflucan absorption after oral administration is very fast, the daily dose is the same for any of its forms (tablets, suspension). As a rule, on the first day of treatment is recommended to double the dose for the rapid achievement of maximum concentration of the active ingredients of Diflucan in the plasma.

Oropharyngeal candidiasis

The recommended dose of Diflucan for the treatment of oropharyngeal candidiasis - two hundred milligrams of the drug on the first day of treatment, and one hundred milligrams of the drug daily for the subsequent treatment. As a rule, all the symptoms of oropharyngeal candidiasis in the treatment diflyukanom disappear after a few days, but the duration of treatment should be at least two weeks to prevent recurrence of the disease.

Oesophageal candidiasis

The recommended dose of Diflucan for the treatment of esophageal candidiasis - two hundred milligrams of the drug on the first day of treatment, and one hundred milligrams of the drug daily for the subsequent treatment. Depending on the response to therapy, daily dose may be increased to four hundred milligrams. The minimum duration of treatment in the esophageal candidiasis diflyukanom - three weeks (two weeks after the disappearance of symptoms).

Systemic candidiasis form

For the treatment of any form of systemic candidiasis (disseminated candidiasis, candidemia, and so on) the optimal dosage of the drug and duration of treatment is determined in each case (a daily dose of Diflucan can be up to four hundred milligrams).

Fungal urinary tract infections: For the treatment of urinary tract diseases caused by fungal microorganisms of the genus Candida, the recommended dosage of the drug is fifty-two hundred milligrams daily Diflucan.

Cryptococcal meningitis

The recommended dose of Diflucan for the treatment of acute cryptococcal meningitis Cryptococcal meningitis - a serious illness   - Four hundred milligrams of the drug on the first day of treatment, and two hundred milligrams of the drug daily throughout the course of treatment. Depending on the reaction body Diflucan daily dosage may be increased to four hundred milligrams. The recommended duration of treatment for cryptococcal meningitis - ten to twelve weeks.