Although normally present in the female body male sex hormones, or androgens, their excess can lead to numerous problems, such as acne, weight gain, hyperandrogenism and hirsutism, menstrual disorders and infertility.
Hirsutism - a disorder in which women because of the increased level of male sex hormones in the body start to grow as dark and coarse hair, both men for a long time was considered a key feature of hyperandrogenism. At the same time, it was difficult to diagnose hyperandrogenism, hirsutism, as may be caused by other diseases. Not all women with hirsutism increased androgen levels, and increase the level of male sex hormones in the female body does not always lead to the development of hirsutism.
Choosing an effective method of treatment is also a challenge. For a long time, most of the patients suffering from hyperandrogenism assigned to treatment in some hormone (usually synthetic estrogen analogues). It was assumed that the combination therapy may be more effective, but studies that could confirm it would be utilized only in small groups of patients.
An important study
Several years ago, it ended a long investigation - perhaps the most extensive of all the studies in which studied the problem of hyperandrogenism
. Scientists are working to identify the most common causes of androgen excess in women and compared the different types of treatment of this disorder
. The findings are cause for optimism for women suffering from various manifestations of hyperandrogenism
. At the same time, scientists conducted the study say that doctors who are treating hyperandrogenism, should better inform patients about the benefits of long-term therapy
. More than 80% of patients who adhered to the accuracy of the treatment plan, comes improvement; in particular, it becomes much less pronounced signs of hyperandrogenism, such as hirsutism, menstrual disorders and acne
. However, many patients drop out of treatment or inadequate faithfully follow the doctor's recommendations
. They, of course, no improvement
. Therefore, one of the conclusions of the study, it was recognition of the need to develop a specific strategy to help improve understanding by patients of the importance of their role in the treatment of
The study lasted from 1987 to 2002, during which time the patient was examined in 1281 with symptoms typical of hyperandrogenism. 873 of them have become participants of the study. After its completion some time spent on the analysis of the results and conclusions.
Two-thirds of the subjects were under 30 years, and 20% of them were under 20 years old when I first went to a doctor complaining of certain symptoms of hirsutism. Since in most cases an excess of androgens makes itself felt even in the period of puberty, it is clear that many patients seek treatment until several years after the occurrence of a problem. After completion of the study, the researchers concluded that about 80% of women diagnosed with hyperandrogenism through quite a long time after her first symptoms appear, and so ill do not receive timely treatment.
Although hyperandrogenism is currently recognized as the most common disorder among women of reproductive age, identifying its causes - not an easy task at all. Among the participants of the study in question, only 59 patients (6.75% of total participants) were identified certain major diseases. Among these diseases are: classical and nonclassical form hyperplasia
Hyperplasia - do not be afraid
adrenal cortex, some types of cancer and other disorders.
In 93.24% of patients hyperandrogenism was diagnosed on the basis of existing symptoms, and using the method of differential diagnosis. Almost 82% of the subjects in addition to hyperandrogenism was found such a violation, as polycystic ovary syndrome (PCOS), at 4.47% of the patients had idiopathic hirsutism - that is, to establish its cause could not, and in 6.75% of cases in women, and increased levels of male sex hormones and hirsutism
Hirsutism - when femininity leaves
ovulation took place perfectly normal. A considerable part of the test was found insulin resistance - a disorder in which insulin levels in the blood increased, due to which increases the likelihood of developing type 2 diabetes, hypertension and heart disease.
More than 75% of patients with hyperandrogenism suffered from hirsutism, 14% had some form of acne, and in 30% of subjects developed infertility.
Approximately 88% of women who participated in the study, ovulation
Ovulation - How to determine as accurately as possible?
there are fewer rules, and in 86% of subjects noted the menstrual dysfunction. In addition, it was found that women with an excess of androgens in the body likely to be obese at twice the rate.
When using medicines for combined hormone therapy, which suppresses androgen production and / or block their activity, improvement was observed in 86% of women suffering from hirsutism. When menstrual dysfunction improvement occurred in 80% of cases, acne - in 81% of cases.
Hair loss - a less common sign of hyperandrogenism - stopped in 33% of patients who were prescribed combined hormone therapy.
More than 60% of the patients there were side effects such as irregular vaginal bleeding, nausea and headaches. Such symptoms can not be attributed to the severe side effects, but it is possible that they are the reason that many of the patients discontinued treatment. Hormone therapy has been assigned to the patient 501, and about half of them are either completely abandoned the treatment or inaccurate followed the treatment plan.
Experts note that, since approximately 25% of women with hyperandrogenism
Hyperandrogenism - if the female body behaves as a male
does not develop hirsutism, it is especially difficult to get adequate treatment. They may suffer from acne, they can be infertility or overweight, which did not manage to get rid of, but doctors do not always prescribe him tests to determine the level of male hormones. Scientists believe that such analyzes need to appoint more women - including those who have no signs of hirsutism. In many cases, this measure can help women improve the quality of life and avoid some of the serious health problems.