Ascorutin - is a combined medication that helps strengthen the walls of blood vessels. It also inhibits the action of free radicals, preventing their toxic effects on the body. Assign Ascorutinum in various diseases, which are characterized by high permeability and capillary fragility.

The mechanism of action Ascorutinum

The composition of the combined preparation contains two vitamin Ascorutinum: ascorbic acid (vitamin C), rutin (vitamin P). Available Ascorutinum Ascorutin - strengthen capillary walls and warn toxic effects svob   tablets, one tablet contains 50 mg of ascorbic acid and rutin.

The mechanism of action consists of Ascorutinum properties of its individual components, which are enhanced when used together.

Ascorutin has a strong antioxidant effect, is involved in redox reactions, carbohydrate, fat (the synthesis of steroid hormones) and protein (the synthesis of connective tissue) exchange, promotes tissue repair, reduces the activity of the enzyme hyaluronidase (which breaks down hyaluronic acid, which is the basis of the intercellular substance) It increases immunity.

Ascorbic acid is the main component that determines the properties of Ascorutinum. It has significant antioxidant properties, is involved in the formation of collagen, strengthens the walls of capillaries, bones, teeth enamel. Participates in the metabolism of carbohydrates, thyroid hormones Thyroid hormones: mechanism of action and physiological effects , Folic acid, improves the absorption of iron by the body. As a result, activation under the influence of ascorbic acid metabolism in tissues reduces the need for vitamins A, E, group B can significantly improve the body's resistance to infections.

Rutin belongs to the group angioprotectors, that is, drugs that have a beneficial effect on blood vessel walls. It helps to relieve swelling, inflammation of the walls of blood vessels, reducing their permeability. Rutin also has antiplatelet properties, ie prevents the grouping of platelets, which prevents blood clots and improves blood circulation in the capillaries. Angioprotective action routine helps to prevent serious complications of vascular organ of diabetes. Rutin helps transport ascorbic acid in the tissue.

Indications and contraindications

Indications for use Ascorutinum are:

• deficiency of vitamin P and C;
• disorders of the capillaries caused by taking medicines that reduce blood clotting (indirect coagulants);
• hemorrhagic diathesis - diseases that are accompanied by bleeding disorders; especially those related to violation of capillary permeability (eg kapillyarotoksikoz or Henoch's disease), and with a decrease in the number of platelets in the blood (eg, idiopathic thrombocytopenic purpura - thrombocytopenic purpura);
• hemorrhages in the retina of the eye;
• damage blood vessel walls in radiation sickness;
• infectious and infectious-allergic diseases of the heart (bacterial endocarditis, rheumatic fever);
• infectious and allergic diseases of the kidneys - glomerulonephritis;
• arachnoiditis - inflammation of the arachnoid membrane of the brain;
• Any allergic diseases;
• infectious diseases, which are characterized by lesions of the capillaries - measles Measles in children - may cause serious complications , Scarlet fever, typhus, influenza.

Application Ascorutinum contraindicated in case of hypersensitivity to it of the patient, in the first trimester (first 12 weeks) of pregnancy before the age of three years. C care Ascorutinum prescribed to patients with increased blood clotting and a tendency to thrombosis, including thrombophlebitis, as well as diabetes, gout and kidney stones.

Side effects

Ascorutinum rarely have side effects, however, they occur:

• allergic reactions such as urticaria, angioedema, and so forth;
• the part of the digestive system - nausea, vomiting, abdominal pain Abdominal pain: Types and Symptoms ;
• on the part of the cardiovascular system - high blood pressure (chronic administration);
• the central nervous system - headache, insomnia (chronic administration);
• by the kidneys and urinary tract - the formation of calcium oxalate stones.

During the reception Ascorutinum should not drink alkaline mineral water, freshly-squeezed fruit and vegetable juices - it violates the absorption of ascorbic acid. Suction its broken well for diarrhea.

Galina Romanenko

The structure Ascorutinum includes two types of vitamins that combine well with each other and have beneficial effects on blood vessel walls. And Ascorutinum Ascorutin - strengthen capillary walls and warn toxic effects svob   has strong antioxidant properties - inhibits the action of toxic free radicals, which are formed as a result of redox reactions.

The principle of operation Ascorutinum

Part of the Ascorutinum ascorbic acid (vitamin C) is involved in all types of metabolism Metabolism: The basis of life of all living things In the intracellular formation of collagen, it is necessary to strengthen the bone, tooth enamel, the capillary walls. Taking part in redox reactions, ascorbic acid inhibits the action thus formed free radicals, thus preventing premature cell destruction. Active influence on all kinds of metabolism reduces the need for vitamins A, E, B1, B2, folic acid, pantothenic acid. Ascorbic acid strengthens the immune system - increases the body's resistance to infections, improves the absorption of iron.

Rutin (vitamin P) promotes rapid delivery of ascorbic acid in the cell, reducing the increased capillary permeability, strengthens the walls of blood vessels, reduces their swelling and inflammation. It has antiplatelet properties - inhibits the ability of platelets to gather in groups, improves blood circulation in the capillaries.

And ascorbic acid, rutin and promote the formation of the intercellular matter and reduce the activity of the enzyme hyaluronidase (which breaks down hyaluronic acid, which is the main component of the intercellular substance), decrease permeability and capillary fragility.

Absolute contraindications for use Ascorutinum - hypersensitivity to its components

Hypersensitivity to the components Ascorutinum can cause allergic or non-allergic reactions are hypersensitive to this drug.

With the development of an allergic reaction occurs first sensitization of the organism -education antibodies (immunoglobulin proteins that destroy the allergens, which in this case is called antigens). During the initial ingestion of antigen does not develop any signs of an allergy, but with repeated contact with an allergic reaction develops.

Non-allergic reactions are hypersensitive to occur at the first contact with a substance to which you are hypersensitivity. At the same time in the body without the participation of the immune processes can be formed mediators (bioactive substances produced during an allergic reaction) and develop non-allergic (also called pseudoallergic) reaction.

According to clinical manifestations of these reactions can not be discerned. They can manifest as urticaria, angioedema, itchy skin rash, anaphylactic shock, and so on.

Relative contraindications for use Ascorutinum

Ascorutin not recommended for use in high doses and long courses at an elevated blood clotting ability and propensity to thrombosis (for example, physiotherapists).

It is not necessary to appoint Ascorutinum as diabetes mellitus Diabetes - threatening and incurable disease   (ascorbic acid has a mild diabetogenic effect), gout and kidney stones Kidney stones - why women tolerate it harder?   (Ascorutinum can enhance metabolic disorder). Also appointed Ascorutinum caution in renal impairment.

Since ascorbic acid increases the digestibility of iron by the body, Ascorutinum should not be administered in hemochromatosis - elevated levels of iron in the blood. The use of ascorbic acid may exacerbate certain types of anemia (sickle cell). Ascorutinum wary appoint patients with deficiency of glucose-6-phosphate dehydrogenase.

Patients with fast-growing and giving metastases of malignant tumors Ascorutinum, which includes ascorbic acid, can weight the course of the disease.

Not recommended Ascorutinum children up to three years, as its efficacy and safety in this age is not confirmed by clinical trials.

In the first 12 weeks of pregnancy (I trimester) Ascorutinum does not apply because of the possible negative effects on the fetus during the Bookmarks organs and tissues. The action of any drug in the fetus during pregnancy and individually predicted with difficulty.

Everyone, even the most innocuous medications, there are contraindications to take into account that only a doctor can.

Galina Romanenko