How to take fluconazole with antibiotics? First of all, on doctor's orders. Fluconazole along with the antibiotics used for the treatment of mixed bacterial and fungal infections, as well as for the prevention of fungal infections developing in patients receiving antibiotics.

How to take fluconazole with antibiotics for bacterial and fungal infections

Mixed bacterial and fungal infections are very common today. Most often found in mixed infections gynecological and urological practice, which were obliterated and difficult to treat. Of bacterial-fungal infections in women are most often yeast-like fungi of the genus Candida and aerobic microbial associations of opportunistic bacteria, such as non-hemolytic Escherichia coli, Staphylococcus epidermidis, and non-hemolytic streptococcus in the background of almost complete absence of normal vaginal microflora The microflora of the vagina: purity   (lactobacilli).

Very often, cutaneous fungal infections are complicated by additional bacterial infections, chronic and often recurrent bacterial infections of internal organs (eg, lung and bronchus) - fungal accession.

The treatment of mixed bacterial and fungal infections Fungal infection: to prevent and defeat   always associated with difficulties. It is carried out only after the detection of infectious agents and their sensitivity to antibiotics and antifungal drugs.

In identifying the fungal pathogen sensitivity to fluconazole at the same time he was appointed to the antibiotic, which is sensitive bacterial pathogen infection.

So with severe systemic candidiasis in combination with a bacterial infection fluconazole appointed concurrently with antibiotic Antibiotics - whether they will help you in the foreseeable future?   on the first day to 400 mg per day, followed by 200 mg. The duration of treatment depends on the patient's condition. In the mixed bacterial and Candida vaginitis Candida vaginitis - a sign of impaired immunity   treatment with antibacterial drugs combined with a single dose of 150 mg fluconazole.

Fluconazole prophylaxis of fungal infections during treatment with antibiotics

The natural microflora that inhabit the skin and mucous membranes of humans in contact with the external environment, is divided into normal or useful and opportunistic. Last, under certain conditions may become pathogenic. Normal microflora hinders the spread of opportunistic, not allowing it to multiply in excess of certain amounts.

For the treatment of infectious and inflammatory processes today are very often used antibiotics. This leads to the destruction of not only the pathogenic microorganisms that caused the disease, but also reduces the amount of normal microflora. But antibiotics do not suppress the vital activity of fungi of the genus Candida, who constantly live on the covers of the human body as part of pathogenic microflora.

The reduction in the amount of normal microflora allows Candida fungi to multiply uncontrollably, penetrate the skin and mucous membranes, causing inflammation - candidiasis. As blood and lymphatic vessels penetrate pathogens fungal infection in the internal organs, causing systemic failure of the body - or generalized systemic candidiasis.

Typically, in such cases, fluconazole is prescribed in the second - the fifth day of the application of antibiotic therapy. The dose of fluconazole and duration of its application depends on the massiveness of antibiotic therapy and the patient's general condition.

Almost always antibiotic treatment of patients with reduced immunity (AIDS, cancer patients after chemotherapy and radiotherapy, and so on) is accompanied by the appointment of fluconazole from the first to the use of antibiotics as reduced immunity is a favorable factor for the development of the fungal infection.

Things to consider

And antibiotics, and fluconazole are effective drugs, which tend to have a lot of side effects. For example, fluconazole have side effects such as liver toxicity. This means that it is impossible to simultaneously apply antibiotics that have similar adverse effects.

Such nuances in the appointment of some drugs there are many, and the doctor must take into account all of them. That is why an independent, non-prescription, the use of drugs can bring a lot of troubles.

Galina Romanenko

Dexamethasone tablets is usually used in short courses for chronic inflammatory and allergic diseases. Take these pills can only be prescribed by a doctor, since prolonged or promiscuous reception dexamethasone Dexamethasone - one of the most effective glucocorticosteroids   may produce significant side effects.

How does dexamethasone tablets

Dexamethasone is a synthetic analogue of the hormones of the adrenal cortex glucocorticosteroid (GCS). Tablets dexamethasone produced a dosage of 0, 5 mg. It is very effective, is by a powerful impact on all types of metabolism has both positive and negative effects on the body of the sick person.

Dexamethasone contributes to the rapid disintegration of proteins using the proteins and their degradation products to produce glucose Glucose: The energy source . A large number of energetic material (glucose) activates the synthesis and decomposition of fat tissue, when it prevails over the synthesis decay.

Decreasing the amount of proteins in blood plasma reduces immunity (for the synthesis of immune cells require protein) and growth inhibition in children. Increased blood glucose creates prerequisites for the development of steroid diabetes, and increased production of fat - obesity.

The positive effect of dexamethasone is that it inhibits the development of inflammatory and allergic reactions by blocking the biologically active substances that cause them. As a result, it reduces swelling, pain, itching, and other symptoms characteristic of inflammatory and allergic processes.

Immunosuppression may also have a beneficial effect, e.g., autoimmune processes, when the tissue of various organs damaged due to too high activity of the immune system.

A positive feature is the ability of dexamethasone to inhibit cell proliferation (cell division) tissues. As is known, most likely fall into tumor cells, so dexamethasone used in oncology. The ability to prevent the proliferation of connective tissue and can be regarded as a positive quality (for example, in the treatment of systemic diseases of connective tissue), and a negative (for example, in patients with myocardial infarction dexamethasone prevents the formation of post-infarction scarring).

Which diseases prescribed

Tablets of dexamethasone administered in the following cases:

• in chronic adrenal insufficiency - as replacement therapy;
• chronic allergic diseases - asthma, atopic dermatitis, eczema, allergic rhinitis and conjunctivitis - short courses to relieve severe symptoms that can not be resolved by other means;
• chronic infectious and allergic diseases, including autoimmune (allergic to its own tissues) - rheumatoid arthritis, ankylosing spondylitis, glomerulonephritis, and so on;
• in systemic connective tissue diseases - systemic lupus erythematosus, scleroderma, and so on;
• oncological diseases;
• congenital adrenogenital syndrome - when the adrenal cortex produces little Valium, which leads to increased amounts in the blood of male sex hormones and menstrual disorders in women.

Contraindications

The use of dexamethasone tablets short courses for health contraindicated only if you are hypersensitive to the components of the drug by the body of the patient. If you need a longer course of treatment, it is contraindicated in gastric ulcer and duodenal ulcers, diabetes, expression of the degree of obesity, osteoporosis, glaucoma, purulent bacterial infection, viral or fungal infection, active tuberculosis, before and after vaccination, during breast Breastfeeding - a personal choice   feeding.

During pregnancy, dexamethasone is used only for health reasons.

Side effect

All the side effects of dexamethasone are manifested in its long-term use. Short courses of treatment with this drug is generally well tolerated.

If we apply dexamethasone prolonged, it is possible to suppress pituitary function and secretion of their GCS adrenal glands, leading to the development of the syndrome Cushing's obesity with the distribution of fat in the upper part of the body, crescent-shaped face, increased body hair, high blood pressure, menstrual irregularities and infertility women impotontsii men.

In addition, dexamethasone inhibits the growth and sexual development in children and adolescents, diabetes Diabetes - threatening and incurable disease , Erosive and ulcerative lesions of the stomach and intestines, a persistent increase in blood pressure, cardiac arrhythmias and heart failure, edema, the occurrence of thrombosis in the blood vessels, osteoporosis, excitement until psychosis and seizures, glaucoma, cataracts, optic nerve damage, and many others side effects.

Galina Romanenko