The mechanism of action JUnidoks Solutab

JUnidoks soljutab (INN - doxycycline) - a broad spectrum antibiotic tetracycline. The drug stops the livelihoods of pathogens by inhibiting the formation of protein in bacterial cells. It is active against many gram-positive and gram-negative microorganisms, including some types of streptococci, staphylococci, E. coli, chlamydia Chlamydia: insidious and widespread disease , Mycoplasma, ureaplasma, and others.

For all of the tetracycline group is characterized by cross-resistance of pathogens to them, that is, if such a resistance to tetracycline was formed, the infectious agent is not sensitive to Boden JUnidoks soljutab.

JUnidoks soljutab rapidly and completely absorbed in the gastrointestinal tract (eating on its absorption almost no impact). Its maximum concentration in blood two hours after administration. In the blood JUnidoks soljutab bound to plasma proteins, into the organs and tissue (cerebrospinal fluid penetrates poorly), through the placental barrier, enters the breast milk accumulates in bone and dentin of the teeth. He then decomposed in the liver and excreted in the urine and feces.

JUnidoks soljutab applied for the treatment of various diseases caused by susceptible to the pathogens: infections of the respiratory and digestive system, pyogenic infections of the skin and subcutaneous tissue, urinary infections, and some infectious diseases.

Indications and contraindications for use

JUnidoks soljutab used to treat diseases caused by microorganisms sensitive to it:

• infections of the upper and lower respiratory tract infections (inflammations pharynx, larynx, bronchus, lung);
• inflammatory diseases of the organ of hearing;
• inflammation of the gallbladder and biliary tract;
• inflammation of the mucous membrane of the rectum (proctitis);
• purulent infections of the skin and soft tissues, including acne Acne: facial trouble ;
• gonorrhea, including complicated;
• infections, sexually transmitted infections: chlamydia; mycoplasma, ureaplasma, venereal granuloma, primary and secondary syphilis Secondary syphilis - can proceed unnoticed for several years   in patients unresponsive or allergic to other groups of antibiotics;
• inflammatory diseases of the kidney and urinary tract;
• inflammatory diseases of the male and female reproductive organs;
• Infectious diseases: typhus, trachoma, borreliosis;
• osteomyelitis (inflammation of bone tissue).

JUnidoks soljutab is contraindicated in:

• increased sensitivity to tetracyclines;
• Pregnancy and lactation Breast-feeding: feed - and no nails!   Child;
• children up to 8 years;
• Serious liver and kidney;
• porphyria (an inherited disorder of pigment metabolism, manifested photodermatosis, hemolytic crisis, gastrointestinal and neuropsychiatric disorders).

Side effects that may occur while taking JUnidoks Solutab

When receiving JUnidoks Solutab may experience the following side effects:

• on the part of the gastrointestinal tract: violation of appetite, nausea, vomiting, diarrhea, inflammation of the mucous membrane of the tongue, small and large intestine, liver damage during prolonged ingestion or in patients with impaired renal and hepatic function, candidiasis;
• central nervous system disorders, reversible: increased intracranial pressure, dizziness, gait and coordination of movements;
• with a side of blood: reducing the number of platelets in the blood (increased bleeding), certain white blood cells (immune system decreases, there is an allergic disposition), hemolytic anemia (occurs by gluing red blood cells);
• From the urinary system: renal failure;
• on the part of the musculoskeletal system: disturbed the formation of bone tissue and the normal development of the teeth (irreversibly change the color of teeth, broken teeth enamel structure);
• and allergic skin reactions: skin rash, urticaria, angioedema, anaphylactic reactions, photosensitivity (allergy to sunlight), exacerbation of systemic lupus erythematosus.

In overdose JUnidoks Solutab may increase the side effects of vomiting, fever, abnormal liver function and kidney function.

What is clindamycin

Clindamycin - a semisynthetic antibiotic lincosamides group, this group is called the group of lincomycin. It has a fairly narrow range of antimicrobial activity. It is active against gram-positive cocci (mainly as a second-line drugs, that is, when other antibiotics can not for any reason apply) and nonsporeforming anaerobic (without air-paced) microflora. Clindamycin suspends intracellular bacterial protein biosynthesis, providing thus bacteriostatic (suspending bacterial growth) effect. At high concentrations of highly sensitive against microorganisms it may be bactericidal (bacteria-killing) effect.

At pathogens, especially staphylococci, quickly develop resistance to clindamycin.

Under what conditions apply

Treatment of clindamycin is effective for infectious diseases caused by bacteria sensitive to it, mainly streptococci, pneumococci, and staphylococci, causing:

• respiratory tract infections (bronchitis, pneumonia, lung abscess Lung abscess - severe consequences of serious illness   and etc.);
• nasopharyngeal infections (tonsillitis, pharyngitis, sinusitis Sinusitis - difficult to cope alone , Otitis media);
• infections of skin and soft tissue (boils, abscesses, cellulitis, infected wounds, erysipelas);
• bone and joint infections (bone inflammation - osteomyelitis, joint inflammation - arthritis);
• septicemia and endocarditis (inflammation of the lining of the heart);
• urogenital infection (infection of the cervix, endometrium, abscesses fallopian tubes and ovaries, chlamydia, etc);
• abdominal infections (peritonitis, abscess Abscess - why it is so dangerous ulcers?   peritoneal cavity);
• oral infections (e.g., abscess, against disease caused on teeth);
• for preventing infection after surgery, including gynecological;
• as an antibiotic reserve.

Contraindications

Clindamycin is contraindicated in:

• if you are hypersensitive to it or to lincomycin;
• with heavy human liver and kidneys;
• under the age of one month;
• If the patient has previously suffered colitis (inflammation of the colon) associated with the use of antibiotics;
• Pregnancy, breast-feeding Breast-feeding: feed - and no nails! .

The dosage forms of clindamycin

Clindamycin is available as a solution for injection, capsules, granules for making syrup in a bottle, vaginal cream, a gel for topical application.

Various firms farmvtsevticheskimi clindamycin is available under the trade names: dalatsin, dalatsin C phosphate klindafer, klindatsin.

What side effects may occur while taking clindamycin

Clindamycin may cause a number of side effects are:

• from the gastrointestinal tract and liver: abdominal pain, nausea, vomiting and diarrhea (in severe diarrhea requires removal of the drug or the continuation of his admission under strict medical supervision); the appointment of the drug inside the possible effects of irritation of the esophagus; there have been cases of jaundice; may develop colitis (both during treatment and 2-3 weeks after the end), which is particularly severe in the elderly and debilitated patients;
• an allergic reaction: hives, itching, in rare cases - expressed dermatitis; also described cases of anaphylactic shock;
• From hemopoiesis system: decrease in blood leukocyte count, neutrophils (decrease defenses), and platelets (possible bleeding);
• with the cardiovascular and respiratory systems: with too rapid intravenous administration of the drug are rare cases of respiratory arrest and cardiac activity, a sharp drop in blood pressure, dizziness, weakness;
• With the genitourinary system: vaginitis, irritation of the external genitalia;
• Local reactions: when administered intramuscularly possible local irritation, pain and abscess formation in the area of ​​administration; It may be the phenomenon of thrombophlebitis;
• in rare cases possible violation of neuromuscular conduction;
• described cases of superinfection, in particular fungal and dysbiosis.

With prolonged use of clindamycin requires systematic monitoring of liver and kidney function, blood composition. With care prescribe clindamycin elderly patients and patients with gastrointestinal diseases, especially those who suffered from colitis. With care prescribe clindamycin in patients with allergic reactions in the past.

Clindamycin - an antibiotic, so it should be administered only by a physician.

  Galina Romanenko