Aktovegin - biological product derived from a natural source. In fact, it is freed from protein (deproteinized) extract of calf blood. Its medicinal properties attributed to a number of pharmacodynamic effects, aimed at improving the metabolic processes in cells. Due to the presence in its composition phosphorus-oligosaccharides inositol aktovegin
Aktovegin - without fear of negative consequences
It has insulin-like effect.
Aktovegin demonstrated high efficacy in the treatment of cerebrovascular insufficiency, ischemic stroke, peripheral circulatory disorders (arterial, venous); angiopathy (disturbance of vascular tone); and trophic disorders (eating disorders of the skin) with varicose veins and ulcers of different origin. This article focuses on the pharmacodynamic action gemidializata calf blood and its use in different clinical situations.
In recent times, you can hear about aktovegin, especially after the hype surrounding Tiger Woods, who took this drug is prescribed by a doctor and found himself at the center of a doping scandal. As mentioned above, aktovegin - is deproteinized extract of calf blood, which is widely used in medicine for the treatment of circulatory insufficiency, senile dementia and peripheral vascular resistance. Manufacturer aktovegina - Austrian pharmaceutical company Nycomed.
Studies have physiological effects aktovegina show that aktovegin activates cell metabolism by increasing the transport and accumulation of glucose and oxygen, increasing their intracellular recycling. These processes lead to an acceleration of the metabolism of adenosine triphosphate and increase energy cells, so that the drug is widely used in sports medicine.
Improved glucose metabolism
In 1996, scientists demonstrated that the main component of aktovegina, phosphorus inositol-oligosaccharides to stimulate glucose utilization in adipocytes. According to scientists, the phosphorus-oligosaccharides inositol have insulin-like effect by regulating the activity of glucose transporter. Increased glucose tolerance occurs, without affecting the levels of endogenous serum insulin
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. This effect is observed in patients with diabetes, but not in people with normal metabolism of carbohydrates.
Improvement of peripheral blood flow
Disorders of the peripheral circulation due to occlusive arterial disease results in pain in the muscles during exercise, and at the hour of rest. The research aimed to study the impact of aktovegina on occlusive arterial disease with intravenous and intra-arterial administration of the drug during exercise, gave the following results: four weeks, patients treated with aktovegin intraarterially, could no pain to go farther than those to whom the drug was administered intravenously ( 44, 37 and 9%, 8%, respectively).
Hypoxic conditions and senile dementia
The function of the parietal lobe of the cerebral cortex - the processing of visual and spatial cues; reduction in parietal lobe atrophy and lead to senile dementia. Aktovegin improve cognitive processing of signals in the parietal lobe of the cerebral cortex in the elderly. In 1995, scientists have demonstrated improved social behavior and cognitive function in patients with organic brain syndrome (acute reversible condition developing cognitive impairment) when administered intravenously aktovegina.
Aktovegin activates the energy metabolism
Improves metabolism and losing weight without dieting
in cells by increasing the transport and accumulation of glucose and oxygen, increasing their intracellular deposit.
Admission aktovegina significantly reduces the recovery period after the injury in athletes. Local injection aktovegina substantially reduce the period of recovery after muscle damage compared to placebo
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Aktovegin and autologous serum
Autologous serum - Serum is the person to whom it is administered. It is obtained by physical and chemical stimulation of blood to increase the specific growth factors, particularly FGF-2, TGF-beta1 and HGF. In the process of muscle regeneration of a number of growth factors involved in the process of muscle recovery, but FGF-2, TGF-beta 1 and HGF - basic controls activation of muscle satellite cells. In 2004, a comparative study of the effect of autologous serum and aktovegina tensile muscles. If local administration of autologous serum reduces the period of muscle recovery (based on MRI), but shows an almost complete return to its original state after 14 days (with edema and hemorrhage), while the control group receiving aktovegin observed only minor side effects .
Aktovegin - one of the most common drugs used to improve cerebral circulation, the treatment of various disorders of blood circulation in the tissues and a number of serious diseases, including the circulatory disorders, as suffering from nutrition of tissues, such as the defeat of the arteries (atherosclerosis) and veins (thrombophlebitis) . The high efficiency of the drug due to its properties to restore the functionality of organs and systems.
Aktovegin improves the transport and accumulation of glucose and oxygen, increasing their intracellular deposit and thereby activates cellular metabolism. These processes lead to an acceleration of the metabolism of adenosine triphosphate and increase energy cells. In addition, aktovegin stimulates energy processes functional metabolism (the process of metabolism in the body) and anabolism (the process of assimilation of substances by the body).
Medicinal properties aktovegina:
- Aktovegin improves anaerobic respiration tissues that lack oxygen.
- Components aktovegina have insulin-like effect in people with insulin-dependent diabetes.
- Aktovegin significantly slows the development of diabetic angiopathy.
- Aktovegin activates the metabolic processes in cells.
- Aktovegin helps with peripheral cerebrovascular diseases (improves vascularization and increases blood flow).
- Aktovegin has immunomodulatory effects.
- Aktovegin improves the transport of oxygen and reduces ischemic tissue damage and thereby indirectly contributes to the formation of cell protein.
All of the above properties aktovegina very interested rheumatologists. The drug is widely used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, systemic scleroderma and other rheumatic diseases. Aktovegin significantly improves the quality of life in patients with abnormalities of the heart and chronic heart failure. During the ten years of its existence in the pharmaceutical market aktovegin proved its high efficiency and safety.
Aktovegina main pharmacological effect is to improve the transport of glucose into tissues and enhancing glucose metabolism. This activates the process of anaerobic oxidation and increases the energy potential of the cells.
- Aktovegin speeds up the metabolism of adenosine triphosphate.
- Aktovegin activates enzymes of oxidative phosphorylation.
- Aktovegin increases the activity of the lysosomal acid phosphatase activity of the cells.
- Aktovegin increases the amount of potassium ions in the cells, which leads to activation of the potassium-dependent enzymes: catalase, sucrase, glucose oxidase.