Systemic vasculitis - a very different diseases affecting different organs and different from manifesting symptoms. Nevertheless, they clearly share one attribute: the defeat of the walls of blood vessels, resulting in disturbed function of internal organs.

The main symptoms of systemic vasculitis

Despite the variety of individual forms of systemic vasculitis, they have a common clinical signs and symptoms. One of these features is the rise in temperature, the peaks of which comes at a time of fresh outbreaks of vascular lesions. At the same time almost all patients appear malaise, weakness, loss of appetite and body weight, a gradual depletion.

Common to all of systemic vasculitis are also skin-hemorrhagic and musculo-articular syndrome, and frequent involvement in the pathological process of the peripheral nervous system.

Skin-hemorrhagic syndrome, systemic vasculitis appears different kinds of hemorrhagic (bleeding a) rash, which is often accompanied by tissue necrosis, followed by the formation of ulcers. Muscle and joint pain syndrome occurs in muscles, joints, and inflammation of the joints.

Pathological processes in the peripheral nervous system manifest neuritis and polyneuritis. Internal organ involvement characterized by multiple and manifest stroke, angina and myocardial infarction, renal, lung (with the development of bronchospasm), liver, spleen, gastrointestinal tract, eyes, and so on.

The disease is mainly long-term, progressive or recurrent (with frequent exacerbations).

Symptoms of temporal giant cell arteritis

When the disease affects the large vessels that carry blood to the skull and brain - carotid, temporal, of vertebrates. Disease begins acutely, with fever, headache, muscle pain, weakness, malaise, pain when chewing. Headache often localized in the temporal region, but may extend to the temporal and parietal region. She has a burning, throbbing character and worse at night. There are also heightened sensitivity and swelling of the skin in the temporal region.

On the scalp nodules appear, artery dense and painful at a palpation on the affected side may be no pulse. It affects eyesight: reduced visual acuity, there is double vision, can develop blindness. Often develop paralysis of the cranial nerves, especially the oculomotor palsy often develop. It is also possible lesions of the brain stem and cerebellum, as well as the organ of hearing with the development of a full or partial deafness.

Rapid detection of disease and the appointment of adequate treatment lead to regression of symptoms of transient visual disturbances. But if there was complete blindness, these changes are usually irreversible.

Symptoms periarteritis nodosa

This disease affects the small and medium-sized blood vessels of the kidneys, heart, gastrointestinal tract, pancreas, liver, skeletal muscle, the peripheral nervous system, the testes. There inflammatory infiltration of all layers of vascular walls to form nodules and small blood vessels to dilate.

Persistent disease manifested fever, exhaustion, pain in muscles and joints, neuritis and polyneuritis. Because of circulatory disorders can appear foci of necrosis (necrosis) in the kidneys (in violation of the functions of this body, the development of malignant hypertension, and glomerulonephritis), heart (myocardial infarction), gastrointestinal tract (with the formation of ulcers).

In the interior of the pancreas Diabetes and pancreas - the things you need to know   and the spleen may appear hematoma (blood) due to violation of the integrity of the vascular wall. Most dangerous is thrombosis Thrombosis - the cause of heart attack and stroke   mesenteric arteries that carry blood to the intestines. This leads to necrosis of the intestinal wall, perforation and peritonitis.

The disease most often acute, subacute but occurs continuously or frequently relapsing progressive. The timely appointment of adequate treatment can stop the progression of the disease process.

Identify systemic vasculitis Vasculitis - when blood vessels refuse to work   sometimes can not afford even the doctor as the disease is rare. Treat it as difficult and certainly not worth doing it yourself. If you suspect a systemic vasculitis Systemic vasculitis: the disease may be different   should seek help from a rheumatologist - the specialist knows how to manifest systemic vasculitis that needs to be done to confirm the diagnosis and how to treat the patient.

Galina Romanenko

Nimesil - a drug that, for all its high efficacy and safety still has a number of side effects of all nonsteroidal anti-inflammatory drugs (NSAIDs). Some of these side effects can be avoided if the drug is used strictly on prescription correctly.

Why is it so important to the correct application nimesil

All NSAIDs, including the latest generation, which relates nemisil, have a negative effect on the gastrointestinal tract and liver. This should be considered first in his appointment (doctor will consider all the indications and contraindications to the drug), and then at his reception.

Wrong taking it can cause complications in a few days of admission. And the side effects of the liver, and allergic reactions may occur after a single dose.

Nimesil has considerably less side-effects on the gastrointestinal tract than drugs such as aspirin, indomethacin, diclofenac Diclofenac - relieve inflammation and pain . But the toxic effects on the liver have nimesil remains, so it is in any case can not be combined with taking other medicines that have an adverse effect on the liver, such as paracetamol. Nimesil can not be combined with alcohol, which has a direct toxic effect (kills) in the liver cells.

All NSAIDs (nimesil no exception) lower rolling capacity of the blood, prolonged uncontrolled use of it can cause bleeding - from the gastrointestinal tract and urinary tract. Increased bleeding threatens hemorrhagic stroke Stroke - a serious brain injury   and other complications associated with the rupture of blood vessels, which is particularly high risk for high blood pressure Blood pressure - dangerous if his swing? . So welcome nimesil not be combined with taking anticoagulants - drugs that reduce blood clotting (eg heparin).

In diabetes there is a change of blood vessel walls, which at elevated bleeding caused nimesilom, can lead to bleeding, so if diabetes nemisil prescribed when absolutely necessary and with caution. Similar problems may occur in the elderly.

Side effects are not allowed to use nimesil children under 12 years of age, pregnant women and nursing mothers.

How to take nimesil

Nimesil take on sachet (it contains 100 mg nimesil) twice a day. Take nimesil fasting is not recommended, only half an hour after eating. Opened bag of pellets, pour them into a glass, add a little less than half a cup of water (100 ml), thoroughly mixed, seeking the dissolution of the granules, and immediately take the (diluted nimesil can not be stored). When severe pain may be a one-off increase in the dose of the drug.

Teenagers aged 12 to 18 years of age and older people without comorbidities are assigned the same dose as adults. But if elderly patients have concomitant diseases of the cardiovascular system, including high blood pressure, increased bleeding, gastric and duodenal ulcers, severe renal impairment, it is recommended to reduce the dose of Nimes. Dose adjustment is needed and in the case when simultaneously being treated with anticoagulants (drugs which reduce blood clotting).

If nimesil given to patients with diabetes Diabetes - threatening and incurable disease It is necessary to take into account the fact that it contains sucrose.

It is not necessary to apply nimesil performing simultaneously work requiring high concentration and coordination of movements, as this drug has side effects such as central nervous system depression and lethargy.

Nimesil avidly binds to plasma proteins, which should be considered in its simultaneous administration with other drugs since it can potentiate (increase efficiency) and increases the toxicity of certain drugs, taking their place in conjunction with plasma proteins (e.g., while taking nimesil and sulfonamides). Nimesil must appoint a physician, picking up with the lowest effective dose as short as possible treatment.

Nimesil is the drug of choice for many diseases involving pain mild to moderate.

Galina Romanenko