The instructions to the drug says that it is contraindicated in pregnancy, as clinical studies in this group of patients have not been conducted. Manufacturer (Latvian pharmaceutical company Grindeks) insists on its recommendations. However, the currently available data on the clinical trials for use in obstetrics mildronata.
Mildronat for the treatment of placental insufficiency
One major problem in obstetrics is a violation of the fetoplacental circulation, ie the circulation in the mother - placenta - fetus. This state has been called placental insufficiency
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(FPN). At the same time the fruit receives less nutrients and oxygen, it is lagging behind in weight and development. First of all from lack of oxygen suffered central nervous system tissue as nerve cells (neurons) are very sensitive to his shortcomings. Consequences of FPI to the fetus can be severe: from stunted physical and psychological development before his death.
For the treatment of FPI there are a variety of treatment regimens, but this condition does not always respond well to treatment. So, for the prevention of FPI in pregnant women at risk for restoration of tissue metabolism and redox processes in cells have traditionally used antioxidants
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(vitamin E, ascorbic acid), drugs that positively affect the liver cells (Essentiale, ho-phytol). For the normalization of the central nervous system is too excitable to pregnant women with a high level of anxiety
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prescribe nootropics (piracetam) and glycine. For the treatment of insomnia drugs prescribed herbal (valerian, lemon balm, motherwort, new passes, Persia).
But this is not always enough, so obstetricians are trying to come up with new ways of applying the treatment of new drugs. Mildronat on the structure and mechanism of action for this purpose, as its primary effect is to protect nerve cells from any external influence, including the lack of oxygen (hypoxia). It also has a positive effect too excitable and anxious patients, normalizing the status of the central nervous system and sleep
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. Antioxidant action of mildronate (i.e., prevention of toxic effects on the cells of free radicals, which are formed as a result of metabolism) is not inferior to the main action used in obstetrics for the purpose of preparations. That is why it started to be used in experimental conditions to protect the cells of the nervous system of the fetus from the toxic effects under the conditions of FPN.
Such use mildronata today experimentally carried out in some clinics in the hospital, for example, printing is evidence that the drug is used in the treatment of FPI in the Institute of Obstetrics and Gynecology named Ott in St. Petersburg. But the use of the drug in a clinical trial to the mass of its application should take a long time. Medicine - a conservative science, all the medicines used to treat patients (and especially pregnant women) should be applied in accordance with the instructions or with the methodological guidelines approved by the Ministry of Health.
In this regard, the majority of obstetricians antenatal mildronat not apply. And rightly so, because the only evidence of clinical trials can confirm the safety of this drug for a pregnant woman and the fetus.
Mildronat to impaired regulation of labor
Another application mildronat found during childbirth. In some cases, during labor is a violation of the coordination of labor, contractions become irregular, their strength is growing, it decreases. Frequently such a condition associated with the condition of the central nervous system, which is the main regulator of all processes in the human body.
Under the experimental conditions under discoordination labor in a combination therapy is administered mildronat, which restores the central nervous system of women and contributes to the restoration of normal labor.
In addition, mildronat in this case has a positive effect on the central nervous system of the fetus, which is suffering in protracted birth from lack of oxygen, as occurs during labor squeezing blood vessels. Mildronat also reduces the oxygen demand of fetal nerve cells, protecting them from destruction.
Thus, mildronat all are used in obstetric practice, but so far only as an experiment. And certainly on their own, without a prescription, women can not use it.
Galina Romanenko
