Urticaria vasculitis may be a distinct disease associated with allergic processes in the body, and a secondary, developing on the background of some other. Therefore, if the patient showed signs of urticaria vasculitis, it must be fully examined.
What is urticarial vasculitis and how it develops
Urticaria vasculitis - is inflammation of the walls of the small veins of the skin, which is manifested by recurrent urticaria rashes. Urticaria rashes are blisters or papules coalescing with each other. Histological examination of the tissue can be seen limited swelling of the papillary layer of the skin, transcending the collagen fibers due to increased permeability of small veins.
Urticaria vasculitis may be one of the manifestations of vasculitis of the skin, which almost always has an allergic basis. The cause of urticaria vasculitis are various infections (including chronic foci of infection), drugs, food allergies are allergic to any substance. In the body under the influence of these factors change the properties of the immune system and in the walls of small veins occur allergic skin reaction initially increases vascular permeability, and subsequently destroy them.
Vasculitis - when blood vessels refuse to work
It may be primary (only the affected skin) or secondary, for example, systemic lupus erythematosus or systemic vasculitis
Systemic vasculitis: the disease may be different
When skin rash is just one of the symptoms of the disease. Secondary urticarial vasculitis develops against the background of some infectious diseases (Lyme disease, mononucleosis, hepatitis B and C), glomerulonephritis, cancer, and during treatment with nonsteroidal anti-inflammatory drugs.
The disease is characterized by a rash of blisters, which in contrast to the hives, more dense, more intensely colored and stay more than a day. Furthermore, when urticarial vasculitis may receive tissue swelling, redness long continuing tissue nodules and some other elements. But sometimes when the rash urticaria vasculitis indistinguishable from lesions in normal hives. And in some cases, the same patient alternate rash, urticaria vasculitis characteristic, typical urticaria.
There are in these patients and the general manifestations of the disease: fever (usually small), malaise, muscle pain and joint pain, inflammation of the joints
Inflammation of the joints - how to relieve the pain?
. There may be a violation of the internal organs: kidneys (glomerulonephritis, renal failure), gastrointestinal tract (nausea, vomiting, diarrhea), eyes (conjunctivitis), airways (laryngeal edema, bronchospasm), nervous system (headache against the backdrop of a small increase in intracranial pressure, paresis and paralysis of the cranial nerves), cardiovascular (cardiac arrhythmia, myocardial infarction).
Diagnosis and treatment
Urticaria vasculitis may be a separate skin disease and a manifestation of some other disease. To assign the correct treatment of the patient, you must first establish the correct diagnosis. Patients with urticaria vasculitis fully examined in order to identify chronic foci of infection, after which they were being treated.
Confirm the diagnosis of urticaria vasculitis is possible only by means of histological examination. In tissue from lesions in, one can see the characteristic vascular changes: swollen and damaged cells in the inner layers of the vein walls, going beyond the blood vessel erythrocytes, fibrin deposition (blood protein) around vessels and so on. Immunological investigation reveals deposition of immunoglobulins (antibodies are composed of them), fibrin around the small veins of the skin.
Urticarial vasculitis Treatment is carried out by suppression of the inflammatory process in the walls of the veins. For this purpose, administered antihistamines, nonsteroidal antiinflammatory drugs. If this treatment fails, use glucocorticoid drugs.
In addition, patients administered plasmapheresis - the blood is cleansed of immune complexes that destroy the walls of blood vessels, phototherapy
Phototherapy - restores vitality
. As a rule, the primary urticarial vasculitis skin respond well to treatment. If this is a secondary disease that is being treated underlying disease that caused it, which leads to improvement of the skin.
Urticaria vasculitis is often a signal of distress in the body, it requires further thorough examination of the patient.