Aerius (active substance - desloratadine) - antihistamine drug group, belonging to the class of so-called H1-antagonists. If an allergic reaction the body produces a special chemical compound - histamine, provoking the appearance of the characteristic symptoms of allergy (skin rashes, runny nose, itching, watery eyes). Desloratadine, part of Erius, and other H1-antagonists neutralize the histamine release in the body.
In general, Aerius is used to suppress the symptoms of seasonal and chronic allergies - including nasal congestion, runny nose, feeling the sinuses and palate, coughing, watery eyes. In addition, Aerius suppresses the symptoms of allergic skin diseases (eg, chronic idiopathic urticaria, or hives) - such as the appearance of skin rashes and itching. Desloratadine usually begins to act within the first seventy-five minutes after dosing. Effect of the drug lasts for an average of twenty-four hours.
Aerius belongs to antihistamine drugs - blockers H1-histamine receptors. Blocking connectivity histamine with its specific receptors (H1), erius not allow contact with the blood of a large amount of histamine and other biologically active substances produced during allergic reactions
How does Aerius
Aerius (active substance - desloratadine) - a highly modern antihistamine that does not have a depressing effect on the central nervous system. Produces erius pharmaceutical company Schering-Plough (USA) in the form of coated tablets for oral administration of 5 mg in 1 ml of syrup which contains 500 mg active principle.
Excipients in tablets are calcium hydrogen phosphate dihydrate, microcrystalline cellulose, corn starch, talc. The structure of the shell consists of: carnauba wax, white wax, lactose monohydrate, hypromellose, titanium dioxide, macrogol, aluminum blue lacquer.
Auxiliaries are propylene syrup, liquid, non-crystallizable sorbitol, anhydrous citric acid, sodium citrate, sodium benzoate, disodium edetate, sucrose, flavors, colorants, purified water.
Aerius has an excellent therapeutic effect and is thus a minimum of side effects. It prevents the development and facilitates the allergic reactions, well relieves itching and swelling of the tissues, reduces the permeability of capillaries, prevents spasms of smooth muscles of internal organs and blood vessels. He misses the brain tissue, so does not cause sedation (sedative) action.
Active ingredient Erius - Desloratadine is the active product of metabolism of loratadine (Claritin active principle). At the same time as the antihistamine desloratadine ten times superior to loratadine, as it has a higher affinity for the H1-histamine receptors.
We have Erius and additional antiallergic effects not related to the blockade of H1-histamine receptors. Thus, it was found that suppresses erius entire chain of reactions which underlie the development of allergic and inflammatory processes.
Such a complex effect on the allergic and inflammatory processes can be successfully applied erius, for relief of acute allergic reactions, as well as for the treatment of chronic allergic diseases.
After ingestion of pills or syrup erius rapidly absorbed and is determined in the blood in half an hour, starting exert antiallergic action. The maximum therapeutic effect is achieved in 1-2 hours and lasts for days.
Types of medication
- Aerius is available in tablet form and syrup for children.
- Erius tablets - round tablets film coated cyan containing five milligrams of desloratadine. Besides desloratadine in the composition in minor amounts tablets include dibasic calcium phosphate dihydrate, hydroxypropyl methylcellulose (dye shell tablet), lactose monohydrate, microcrystalline cellulose, polyethylene glycol, titanium dioxide.
- Erius in the form of a syrup is a clear, orange liquid with a sweet taste and a content proportion of desloratadine in half a milligram per milligram liquid. The syrup composition includes, in addition desloratadine, some adjuvants - including anhydrous citric acid, disodium edetate (ethylenediaminetetraacetic acid disodium salt is used as the excipient), sodium benzoate, sodium citrate dihydrate.
Aerius is not recommended to receive allergy to desloratadine or any other ingredients of the product.
Indications for use
Aerius is widely used for allergic rhinitis (both seasonal and year-round), it effectively suppresses swelling (relieves nasal congestion) and increased exudation (runny nose), which can not be removed by other sovremennymipreparatami this series. He copes with other symptoms that arise in allergic rhinitis - itching and redness of the eye
Red eyes - an occasion consult an ophthalmologist
, Lacrimation, and itching sore throat, cough, and so forth.
When combined with allergic rhinitis with asthma Aerius is also effective. This erius suppresses allergic rhinitis symptoms and positively affect the course of asthma due to improvements in respiratory function and reduce the need to use drugs with bronchodilators (dilate bronchi) action.
Increasingly, Aerius is indicated for the relief of acute urticaria and treatment of chronic urticaria. Chronic urticaria - a disease that is difficult to treat. According to experts, erius cope with this task. Under its influence significantly reduced itching, number and size of lesions, improves sleep
Dreams: how to understand our dreams
. This erius not possess sedative or hypnotic effect - sleep is improved by the fact that are worried sick symptoms.
Aerius is used for other allergic diseases and conditions. For example, in contact allergic dermatitis, atopic dermatitis, neurodermatitis and so on.
How to take Aerius
Aerius tablets: the standard recommended dosage for adults and children aged twelve years and older - five milligrams per day (one tablet) with food or by itself.
Aerius syrup in the form of: the standard recommended dosage for adults and children aged twelve years and older - ten milliliters of syrup (five milligrams of desloratadine) once a day. For children aged between six and eleven years the recommended dose is five milliliters of syrup (two and a half milligrams of desloratadine) once a day. For children aged from two to five years - two and a half milliliters of syrup once a day. Syrup can be taken together with a meal, or separately. Children from two to twelve years is not recommended to welcome Erius for more than two weeks.
In some cases, Aerius is contraindicated
Contraindications for use Erius not so much, because along with high efficiency, he has at least a high security. Nevertheless, it can not be used during pregnancy (no experience of its use in pregnant women) and nursing
Breastfeeding - a personal choice
feeding (excreted in human milk), as well as increased sensitivity to its components of the patient. Aerius tablets is not recommended for children under 12 years, and syrup - up to a year (the effectiveness and safety Erius infant has not been tested). Syrup is not administered to patients suffering from hereditary fermentopathy (carbohydrate malabsorption due to lack of certain digestive enzymes).
Be wary appoint erius severe kidney disease with severe violation of their functions. In addition, the effectiveness of the therapeutic effect at a cold Erius infectious origin has not been tested, so it is impossible to say exactly how it will be effective in this case. This is especially true of young children who are difficult to distinguish allergic rhinitis from infection. Therefore, to apply or not apply in such cases erius, solves a doctor.
Do Erius side effects?
No side effects not do, but they Erius minimized. Thus, clinical trials revealed the following side effects from the tablets erius: fatigue, dry mouth, headache, dizziness, tachycardia (very rare), transient liver function abnormalities in the form of changes in laboratory parameters, allergic reactions - rarely in the form of urticaria and very rarely - in the form of anaphylactic shock.
Side effects may occur with ingestion Aerius syrup. For children aged up to two years while taking this drug sometimes appear the following symptoms: diarrhea, fever, insomnia. In children aged between two and 11 years in the application of Erius similar side effects are much rarer. In adults and children older than 12 years in the application of Erius sometimes appeared fatigue, drowsiness, dry mouth, headache, dizziness. Perhaps also cause nausea, vomiting, transient liver dysfunction and allergic reactions such as urticaria, angioedema, anaphylactic shock.
The manufacturer's recommended dose of Aerius does not affect the ability to drive vehicles or operate machinery.
Is it possible to overdose Erius?
In overdose Erius theoretically may increase side effects. However, during clinical trials in adults and adolescents administered doses far exceeding the therapeutic (5-9 times) over a period of 10 to 14 days, and it did not cause any adverse changes in the organism. In clinical practice hitherto unknown as well overdoses of the drug.
However, the manufacturer recommends an accidental ingestion of large amounts of Erius (regardless of the dosage form of the drug) to call an ambulance, stomach wash and take a few tablets of activated charcoal
Activated carbon - old but indispensable
(activated charcoal tablets grind better and take the form of a powder). When side effects of symptomatic treatment.
Aerius can be taken while eating (or independently of it) and with other medicines, including affects the central nervous system. Unlike other antihistamines erius does not increase negative impact on the central nervous system of alcohol.
Aerius - a modern, highly effective and safe drug for the treatment of allergies.