Asparkam - a drug, which is composed of potassium and magnesium. These minerals are essential for the functioning of the cells of various tissues, primarily for muscle tissue and particularly the heart muscle (myocardium). But an overdose of potassium hardest impact on the functioning of the heart muscle.
Side effects asparkama on the cardiovascular system
Intracellular mineral potassium helps to restore the functioning of the cells of the myocardium, which leads primarily to normalize heart rhythm. Under the influence of potassium slows down the process of transmission of nerve impulses in the conduction system of the heart, decrease heart rate and myocardial contractility better. Such action asparkama is in tune with the action of cardiac glycosides - drugs that are used to enhance myocardial contractility in heart failure
Heart failure - when the heart is unable to cope with the work
. Cardiac glycosides - it is quite toxic drugs, they can cause, including, and cardiac arrhythmias. Asparkam in this case reduces the side effects of cardiac glycosides and allows to apply them to a lesser dosage.
But property asparkama to slow the nerve impulses on the cardiac conduction system can play a negative role, particularly if their conduct and so breached. Especially dangerous is the use asparkama with significant violations of the conductivity of nerve impulses from the atria to the ventricles - atrioventricular blockade II-III degree. It is also possible decrease in blood pressure and increased heart rhythm disorders.
Side effects asparkama in the gastrointestinal tract
On the part of the gastrointestinal tract in patients receiving asparkama may cause dry mouth, nausea, vomiting, diarrhea, abdominal pain, bloating.
This happens due to the fact that when the body is elevated potassium include adjustment mechanisms to facilitate on the one hand its assimilation by cells, and the other - the removal from the body. Thus, it may increase the amount of urine (which leads to a certain dehydration and dry mouth) and potassium excretion through the gastrointestinal tract, which is manifested by symptoms such as nausea, vomiting and diarrhea, as well as their accompanying symptoms of bloating
Bloating - if you are bursting inside
and pain along the intestine.
What other side effects may have asparkam
On the part of the central nervous system in the application may cause dizziness asparkama
Dizziness - if the ground is slipping from under his feet
. It is also possible the appearance of muscle weakness, constant fatigue and reduced performance - a consequence of slowing of nerve impulses in the nerve-muscle fibers.
But the most serious side effects occur with intravenous asparkama, particularly if the drug is injected rapidly enough. In this case, there is a risk of severe hyperkalemia and hypermagnesemia a sudden reddening of the face, thirst, muscle weakness and fatigue, until the complete temporary immobilisation, seizure, sudden drop in blood pressure
Blood pressure - dangerous if his swing?
, Respiratory disorders. It is also possible the emergence of such paradoxical features, like an increase in heart rhythm disorders. Against the backdrop of all these changes, the patient may fall into a coma.
Moreover, when administered intravenously asparkama thrombosis may develop - an inflammation of the vein walls, which is accompanied by an increased thrombosis.
When receiving asparkama inside an overdose is extremely rare, whereas when it is administered intravenously, it is quite possible. The main sign of overdose is heart block - a violation of the conduction of nerve impulses in the myocardium. Especially dangerous are such complications if the patient has had any cardiac conduction.
When overdose patient intravenously administered drugs that could adjust his state of water and electrolyte balance. And as an antagonist of potassium in the body is sodium, the solutions are usually used to contain it. Are introduced and solutions with calcium, which is also able to restore the water and electrolyte balance in excess of potassium in the blood.
Which combination of drugs may increase the effects of asparkama
Action asparkama (and thus the risk of hyperkalemia) can enhance certain drugs that reduce blood pressure (eg, beta-blockers, ACE inhibitors), nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics, which have potassium-sparing effect (triamterene, veroshpiron), salt substitutes, having in its composition of potassium.
Asparkam - a non-toxic drug, but its action can cause serious complications, especially with parenteral (bypassing the gastrointestinal tract) administration.