The problem of the treatment of endocrine diseases is very relevant, as they are quite widespread. Thyroid pathology is in need of medical correction of hormonal disorders, taking into account the initial hormone levels. Treatment of thyroid hyperplasia possible preparations containing iodine or thyroid hormone, as well as by other means, including the means of non-pharmacological treatment.

Appointment of thyroid hormones in prostate hyperplasia

In identifying hyperplasia Hyperplasia - do not be afraid   against the backdrop of endemic goitre, when iodine deficiency is noted, and it enters the body in an amount that is insufficient for the full functioning of the prostate, a patient receives drugs containing thyroid hormones. They should be used for therapeutic purposes under the following conditions:

• gland hyperplasia of the third degree and more
• hyperplasia of the second degree with euthyroid state, when there is a tendency to progression of the process and to further increase the size of the prostate

Conduct thyroid hormone therapy is possible only after a comprehensive examination of the patient and diagnosis, the degree of increase in cancer. The leading role in the diagnosis belongs ultrasound scan. The most common drug is thyroxine. It is to be introduced gradually, starting with a minimum maintenance dose. The greatest effect can be achieved with the early onset of therapy, so it is important to consult a doctor for examination when the first complaints or early signs of trouble in the body. The dose should be increased depending on the survey results until a euthyroid state. For thyroxine Thyroxine - the main thyroid hormone   50 mg dose should be initial and optimal dose is between 100 mg and 200 mg. When there is a decrease in prostate size during treatment, decreases the severity of clinical manifestations, it is possible to reduce the dose received and leave it as a prophylactic. It is necessary to conduct patient follow-up visit every three months. An objective examination can estimate the size of the prostate, which should be measured the circumference of the neck over time. The most accurate information enables the measurement of the size and scope of the body by means of ultrasound scanning.

In the case of a marked increase in the size of normal prostate and in the event of symptoms squeezing or compression of the surrounding tissues, blood vessels, nerve endings need to raise the question of the operational methods of treatment. During the operation, the amount is determined, in this case can be removed only part of the prostate or share.

Only unexpressed degree gland hyperplasia without effects of hormonal disorders is not an indication for drug therapy. If the functional activity of the gland is not broken, the patient is compensated, it should be actively observed in the appropriate specialist and undergo regular inspection.

The efficacy of traditional medicine

According to the research it has proved sufficiently high efficiency of plant assets, which in large quantities can be found in the recipes of traditional medicine. It is widely used for medicinal purposes in thyroid hyperplasia Thyroid hyperplasia - prevalence of endocrine pathology   the root of cinquefoil white .  From it is prepared alcoholate, which should be crushed root of the plant and pour 100 grams of raw materials with one liter of vodka .  Such infusion stored in a dark place for three weeks, after which it can be eaten by dropwise .  It is better to drink brandy before eating, after dissolving drops in a little water .  Within a month, you need to drink the infusion of cinquefoil, and then take a break for a few weeks .  After the break, you can repeat the cure .  Potentilla drink in the form of infusion of herbs .  Grass must first crush, take two tablespoons of raw materials and fill a thermos with boiled water (just two cups of water) .  To get the infusion should leave the grass at night in a thermos, then strain and drink several times a day for half a cup of infusion .  By its healing properties can be called bloodroot plant with unique healing properties due to the content of a large number of important trace elements, including elemental iodine .  This explains the positive result of the application of this plant in the treatment of thyroid disease .  The largest number of useful minerals is at the root of the plant, therefore, is not recommended for the treatment leaves only .

Another plant, an infusion of which can be recommended for the treatment of hyperplasia is thyme. Grass pour boiling water (it should take one spoonful of raw materials and a glass of water) and insist half an hour. In this medical glass infusion should drink twice a day, you can expect a positive result after a few weeks. Also apply Pulmonaria officinalis, oak bark, grass cocklebur. Fresh oak bark or bark powder can wipe the neck area, which will help reduce the size of the prostate. Some wear the bark of oak as a necklace around the neck, which is also a healing factor in the treatment of hyperplasia.

An integral part of the course of treatment is proper diet Proper nutrition - the basic precepts of healthy food   patient. It is recommended to prepare a "mess" or a mixture of the main ingredients of which are walnuts, buckwheat honey. Nuts are very useful, they must be included in your diet for therapeutic purposes in prostate hyperplasia. Buckwheat and nuts to grind in a coffee grinder, add honey to the mixture. All the constituent components of cereals are taken in equal proportions of 200 grams. During the day eat the recommended therapeutic mixture, then make a break for three days and then repeat the course. The effect can be expected after three months, so during this period of time health food should not be stopped.

Marina Solovyov

Wilson's disease - an inherited disorder of copper metabolism leading to excessive deposition of the latter in the internal organs (liver, cornea, brain). The basis of the disease is a violation of the separation of copper in the bile. Due to the excessive accumulation of copper increases the production of free radicals and damaged tissue.

Wilson's disease is suffering one of the 30 000 people in the world. The main role in the pathogenesis of metabolic plays copper, its accumulation in the nervous, renal, hepatic tissue and cornea, as well as damage to copper toxicity of these bodies. Metabolic disorder is expressed in violation of synthesis and decrease in the blood concentration of ceruloplasmin. Ceruloplasmin is involved in the elimination of copper from the body. The liver is formed by SKD or mixed cirrhosis. In the kidney primarily affects proximal tubules. In the brain, are affected to a greater extent the basal ganglia, cerebellum and the toothed core substantia nigra.

Wilson's disease - a hereditary disease; its symptoms often occur between the ages of 6-20 years. However, cirrhosis of the liver can be detected already in children under five years of age. On the other hand, Wilson's disease may develop in elderly patients (over 40 years), accompanied by signs of severe liver injury, but without neurological symptoms or without Kayser-Fleischer rings.

Kayser-Fleischer ring - deposition on the periphery of the cornea containing copper greenish-brown pigment - a typical symptom of Wilson's disease, the most pronounced in advanced forms of the disease. Sometimes there yellowish-brown pigmentation of the skin of the trunk and face, frequent hemorrhagic phenomena (bleeding gums, nosebleeds, positive test harness), marbling of the skin, as well as the typical nervous system.

Causes

Wilson's disease is associated with a mutation that leads to a decrease in blood concentrations of copper transporter belka- - tserruloplazmina. As a result, violated the normal distribution of copper - it accumulates in the body too much, and it's more likely to suffer liver and midbrain (the so-called lenticular nucleus).

Two variants debut Wilson's disease: liver (cirrhosis of the liver) and neurological (mainly affecting the basal ganglia, cerebral cortex and cerebellum, neurological manifestations presented tremor, choreiform movements of the limbs, grimacing, can develop epileptic seizures). In the first embodiment, the disease usually begins at age 11, the second embodiment 19, but the disease may occur occasionally and 6 decade of life. Hepatic and neurological disorders occur with approximately equal frequency, and in the absence of treatment, patients develops over time, both types of pathology. The disease is in the initial stages can occur only mental disorders - patients can be long and unsuccessfully treated by a psychiatrist. The debut of the disease as possible with joint disorders, fever, hemolytic anemia.

It will be appreciated that an excessive concentration of copper in the body of the patient leads to cirrhosis of the liver, impaired glucose tolerance (diabetes), abnormal enlargement in one or another vessel (aneurysm), rahitopodobnyh development of the disease, accelerated atherosclerosis.

The disease is transmitted in an autosomal recessive manner, due to the low or abnormal synthesis of ceruloplasmin - a protein transporting copper. The gene ATP7B, mutations that cause the disease, located on the thirteenth chromosome.

In a number of cases in isolated liver disease for diagnosis requires various laboratory parameters. Acute hepatitis Hepatitis - the scourge of our time   Wilson's disease is indistinguishable from other acute diseases of the liver, and it is necessary to exclude young patients with a picture of acute hepatitis Acute hepatitis - always seriously   neither A nor E. In the absence of timely treatment of Wilson's disease can cause severe brain damage, kidney failure or death.

Diagnostics

An important diagnostic feature is the detection of brown ophthalmologist bilateral corneal rings, whose origin is associated with the deposition of copper. This so-called Kayser-Fleischer symptom - it is found in almost all patients with Wilson's disease.

Histological examination of liver fibrosis determined. The disease can progress rapidly, resembling fulminant hepatic failure. A large amount of copper released from the dead cells of the liver and contributes to the development of deep hemolytic anemia complicating acute liver damage. A combination of symptoms, such as anemia, severe jaundice and relatively low activity of aminotransferases, should guard against acute course of Wilson's disease.

Excessive deposition of copper in the body caused by a genetic defect caused by a spontaneous gene mutation ATP7V. Wilson's disease can be "inherited" only if the child receives the gene from both parents. At this point it was discovered more than thirty different mutations ATP7V, so it is very difficult to develop a uniform procedure of genetic testing for the diagnosis of Wilson's disease.

However, if the family found a specific gene mutation, genetic prognosis can be made that will help to identify family members who have no symptoms, and thus begin treatment before they can be seriously affected. Timely diagnosis and prescription of treatment in patients with Wilson's Syndrome - is the key to a long and fruitful life.

Symptoms and signs

Wilson's disease manifests various symptoms. The most frequently detected signs of liver disease, hemolytic anemia and neuropsychiatric disorders, such as suicidal tendencies, depression Depression - a little more than a bad mood   and bouts of unwarranted aggression. Women have also been irregular menstruation, amenorrhea, infertility, or the inability to tolerate pregnancy.

In most patients, irrespective of the type of disease and the initial state before the development of symptoms, it has liver varying severity. Liver damage occurs by the type of chronic hepatitis B Chronic hepatitis - a diagnosis for life   or cirrhosis and clinically characterized by hepatomegaly, hemolytic anemia, thrombocytopenia, leukopenia. Also, there is damage to the nervous system (hyperkinesia, increased muscle tone, and \ or paralysis, athetosis, seizures, drooling, dysarthria, behavioral disorders, speech).

As already mentioned, the most characteristic feature of Wilson's disease are Kayser-Fleischer ring - brownish rings on the cornea of ​​the eye that can detect only an ophthalmologist at the examination.

Treatment of Wilson's disease

Many years have passed after the discovery of the disease before it has been found a means to deal with this disease - a drug that reduces the concentration of copper in the body - D-penicillamine (kuprenil), which is effective in 90% of cases. Treatment penicillamine accompanied by a marked improvement in the condition of patients, or even lead to the complete elimination of symptoms. Take penicillamine should be kept at 1, 5-2 g orally daily.

It is also recommended that a diet high in vitamin B6, copper restriction to 1 mg per day - the exception of chocolate, nuts, dried fruits, cancers, liver, whole wheat.

If medsnizhayuschaya therapy is started early in the disease with minor manifestations of neurological deficit, the condition of patients is completely normal; in advanced cases, unfortunately this is not happening.

Monitoring of the concentration of ceruloplasmin, copper and zinc in the blood of the patient should be carried out several times a year. Constant reception penicillamine ensure normal, healthy standard of living in most patients. Most people continue to work, to lead an active life. Externally, such a person does not differ from healthy.