The choice of treatment depends on what form of acute pancreatitis is diagnosed in the patient. What are the treatments used?
A mild form of acute pancreatitis
When treating patients with mild forms of acute pancreatitis, usually fairly standard therapy.
The patient can not eat as long as the pancreas stops the inflammatory press - it usually takes about five days. The need to digest solid food during this period lead to an excessive load on the pancreas.
Since pancreatitis possible lung damage and disruption of normal pulmonary function, oxygen is injected into the body by a tube inserted into the patient's nose. Tube removed after a few days, as soon as it becomes apparent that the patient went to the amendment.
In addition, through a tube into the vein introduce special liquids - otherwise, during his stay in hospital the patient will suffer from dehydration.
Even with mild forms of acute pancreatitis, the patient may suffer from very severe pain, so he may be assigned to the reception of powerful analgesics contain opioids, causing drowsiness. If you visit in the hospital a man who was diagnosed with acute pancreatitis, it inactive scattered state should not bother you - this is a normal reaction to analgesics.
Treatment of the main causes mild forms of acute pancreatitis
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If in the course of diagnostic procedures, it was found that developed acute pancreatitis due to gallstone formation in most recommended surgically remove them. This can be done while the patient is in the hospital, and it is possible to perform the surgery in a few weeks after discharge. Removal of the gallbladder should not have a significant impact on the health of the patient - except that it will be difficult to digest certain foods, such as fatty and spicy foods.
All patients who were diagnosed with acute pancreatitis, six months is necessary to completely abstain from alcohol consumption. This is due to the fact that alcohol can lead to further damage to the pancreas
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in the recovery period - even if acute pancreatitis was not caused by alcohol.
If you find it difficult to give up alcohol - for example, if you have developed alcohol dependence, you may be required to undergo treatment for alcoholism. This is necessary in order to successfully treat acute pancreatitis continue to live healthy, fulfilling lives.
Severe acute pancreatitis
Patients diagnosed with a severe form of acute pancreatitis is usually for a while placed in the intensive care unit. The level of liquid in them, as a rule, substantially reduced, since the body uses fluids and nutrients, trying to restore the pancreas. Reducing fluid can lead to a decrease in circulating blood volume - a condition known as hypovolemic shock. This condition can be life-threatening because the body quickly begins to lack oxygen-rich blood it needs to survive. To prevent the development of hypovolemic shock, in the body fluid is introduced through a dropper. The patient is also administered oxygen; in some cases, a ventilator.
In addition, through a tube to a patient is administered a liquid containing nutrients. To alleviate pain analgesics.
Treatment of the main reasons
As with mild forms of acute pancreatitis, the therapy needed to treat acute forms of the main causes of the disease. If the cause is gallstones, in most cases, it is recommended to remove them. If a severe form of acute pancreatitis developed because of alcohol abuse, the patient must give up alcohol and undergo treatment for alcohol addiction
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Leflunomide - a new tool for the treatment of acute pancreatitis?
Nuclear factor kappa B is a strong mediator on several stages in the development of acute pancreatitis. Leflunomide - a new immunomodulatory drug that is a potent inhibitor of nuclear factor kappa B. In one study examined the effects of leflunomide in rats with acute necrotizing pancreatitis.
Fifty rats used for the study were divided into five groups. Necrotizing pancreatitis was induced by injection three percent solution of sodium taurocholate. Experimental rats to injections were given two doses of leflunomide, intragastrically. Doses were calculated by the formula 10 mg per 1 kg weight. The study recorded changes in the level of amylase in serum, histopathological changes pancreatic tissue level of malondialdehyde, myeloperoxidase activity and changes in pulmonary function.
Admission leflunomide significantly reduced bleeding pancreas, edema and neutrophil infiltration
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and reduced the number of histopathological changes in comparison with a group of rats who were not given leflunomide. The number of changes in pulmonary function in the groups given the drug, also had less. The level of amylase in these groups was also lower, but not significantly.
The study researchers concluded that leflunomide is useful for the treatment of acute pancreatitis in rats, and it can be viewed as a means to treat the disease in humans.
Infliximab - a new therapeutic agent for the treatment of acute pancreatitis
Tumor necrosis factor-alpha plays a key role in the pathogenesis of acute pancreatitis and related systemic complications. Recently, scientists have investigated the therapeutic efficacy of infliximab in the treatment of acute edematous pancreatitis and necrotizing rats.
For the study used 100 rats. In some of them induced edematous pancreatitis, the other part - necrotizing pancreatitis. The researchers carefully monitor changes in the status of experimental animals.
Treatment with infliximab in rats with acute pancreatitis both types significantly reduced the level of amylase in serum and the number of histopathological changes. It is also inhibited neutrophil infiltration, and myeloperoxidase activity in the tissues of the pancreas. Furthermore, using infliximab able to reduce necrosis of pancreatic tissue and to reduce the likelihood of serious complications related to pulmonary function.