Creon - instructions for use of the enzyme preparation contains detailed information about its mechanism of its action, indications and contraindications, side effects and storage conditions. Sold most dosage forms Creon without a prescription. Only high doses of this drug requires a prescription.
The mechanism of action of Creon
Active ingredient is a pancreatin Creon - pancreatic juice, which is composed of enzymes that break down proteins, fats and carbohydrates. Creon is a special feature of its formulation. Creon is available as capsules for oral administration of different dosages. After ingestion of the capsule rapidly dissolve at the junction of the stomach into the intestine, releasing a plurality of microcapsules which are mixed with the contents of the stomach and move with it into the duodenum. Microcapsules (microspheres) coated with enteric-coated so dissolve in the intestine, releasing enzymes that help to break down fats, carbohydrates and proteins (lipase, amylase, protease). The process of digestion of food is improving, then it is completely absorbed into the bloodstream. Availability pancreatin microsphere allows better mixed with food, which enhances the effectiveness of the drug.
Auxiliaries, members of Creon capsules
Creon - medicine to help digestion
are macrogol 4000, hypromellose phthalate, 1000 dimethicone, cetyl alcohol, triethyl citrate. The composition of the capsule shell include gelatin, yellow iron oxide, red iron oxide, titanium dioxide, sodium laurylsulphate. Creon capsules are produced with different doses of pancreatin: Creon 10000 contains 150 mg pancreatin Creon 25 000 - 300 mg, Creon - 40 000 - 400 mg. Manufacturer Creon - international pharmaceutical company Abbott Products.
Indications and contraindications
Creon is used as replacement therapy in reducing or total disruption of the digestive secretion of pancreatic juice in the following diseases and conditions:
- cystic fibrosis - a serious hereditary disease affecting the pancreas and the almost complete absence of its functions;
- chronic pancreatitis - inflammation of the pancreas, a gland in which cells are gradually replaced by connective tissue with decreased function of the body;
- state after removal of the pancreas;
- pancreatic cancer;
- ductal obstruction of the pancreas or common bile duct (in a flow duct carrying pancreatic juice and bile);
- Shvahmana Diamond syndrome - a hereditary disease, which interferes with the function of the pancreas and bone marrow;
- reducing the function of the pancreas
Diabetes and pancreas - the things you need to know
in elderly patients.
In addition, Creon take to improve the digestive process in violation of the other digestive organs in the following diseases and conditions:
- state after removal of the gallbladder (cholecystectomy);
- state after complete or partial removal of the stomach;
- state caused by stagnation of food in the stomach and duodenum (gastrostasis, duodenostasis);
- obstruction of bile ducts (biliary obstruction);
- hepatitis on a background of stagnation of bile (cholestatic hepatitis);
- cirrhosis of the liver;
- diseases end of the small intestine;
- bacterial overgrowth in the small intestine.
Contraindications receiving Creon in acute pancreatitis, exacerbation of chronic pancreatitis, hypersensitivity to pancreatin of porcine origin and the other components of the drug.
With caution and only as directed Creon prescribed during pregnancy and nursing
Breastfeeding - a personal choice
Side effects of Creon and his possible overdose
Creon is well tolerated by patients of all ages. Because of the side effects of this drug note the following manufacturers:
- from the gastrointestinal tract - nausea, vomiting, abdominal pain
Abdominal pain: Types and Symptoms
Constipation or diarrhea;
- allergic reactions such as skin rash.
Moreover, in cystic fibrosis patients treated with high doses kreon long time, can develop colitis and stricture ileum and cecum. However, the exact relationship between the development of such a complication, and taking Creon finally installed.
With an overdose of Creon in the blood and urine may appear an excess of uric acid salts (urate), so long-term use at high doses Creon may be complicated by the formation of kidney stones.
Creon - a modern efficient enzyme preparation, which is applied, as in the human pancreas and digestive problems associated with other diseases of the gastrointestinal tract.