Duspatalin - a drug with antispasmodic action. It relieves spasms of smooth muscles of internal organs of the digestive system, including the gastrointestinal tract, ducts of the pancreas, bile ducts and gallbladder.

The mechanism of action Duspatalin

Duspatalin (INN - mebeverin) refers to myotropic antispasmodics, which have a direct relaxing effect on the smooth muscles of the digestive system. Antispasmodic effect Duspatalin far exceeds the action of drugs such as papaverine Papaverine - for pain caused by spasms of smooth muscles   and no-spa. This Duspatalin not suppress natural peristalsis of the digestive system, which is very important for their full operation, particularly for the bowel. At the same time relieves pain associated with spasms and increased motor activity of smooth muscles of the digestive system.

Releases Duspatalin international pharmaceutical company Abbott capsules prolonged action. Each capsule contains 200 mg of mebeverine hydrochloride.

After receiving the drug inside the capsule is completely decomposed in the body. At the same time beginning the formation of acid and mebeverina veratric that falls to the receptors of smooth muscles and relieves her increased motor activity. A dosage form as capsules prolonged action allows mebeverina released for a long time, providing prolonged effect on the smooth muscles of the digestive organs. In connection with such a feature Duspatalin could be taken twice a day, while achieving maximum analgesic and spasmolytic effect.

Other pharmaceutical companies mebeverin issued under the title spareksa and mebeverina.

Indications and contraindications for use - instructions

Duspatalin used to relieve spasms and associated pain of smooth muscles of the digestive system in the following diseases and conditions:

• intestinal colic of any origin, including those associated with increased gas production on the background of dysbiosis and intestinal candidiasis, chronic colitis and enterocolitis, irritable bowel syndrome;
• pain associated with spasms of the stomach wall and duodenum in chronic gastritis, duodenitis and peptic ulcer;
• with biliary colic, developing on the background of diseases of the gallbladder and biliary tract, including cholelithiasis;
• acute and chronic pancreatitis, when strong girdle pain associated with spasms of smooth muscles of the pancreatic ducts;
• spasm at the sphincter of Oddi - closing a circular muscle that regulates flow into the duodenum bile and pancreatic juice Diabetes and pancreas - the things you need to know ;
• for any functional disorders of the digestive organs, which are accompanied by abdominal pain.

Duspatalin contraindicated if you are hypersensitive components of the drug to the sick and aged under 18 years (not conducted clinical trials in children and there is insufficient evidence of its efficacy and safety in this case).

No clinical trials were conducted on pregnant women, therefore the dyuspatallin during pregnancy should be used with caution, only on prescription and for health reasons. There is insufficient evidence about whether it is allocated Duspatalin with human milk and therefore nursing mothers should be taken with caution, interrupting for the duration of breastfeeding.

Take Duspatalin before eating, swallowing the capsule whole and squeezed her half a glass of water. Prescribers usually one capsule twice a day. The duration of treatment depends on the patient's condition.

Side effects and overdose

Duspatalin generally well tolerated, and side effects of known only to allergic reactions which can occur in the form of urticaria, edema Prevention and treatment of edema - it is important to understand the root cause   Angioedema and itchy skin rashes. Duspatalin no adverse effects on motor coordination and attention, so during the course of treatment, you can engage in any activity, including driving a car.

Overdose Duspatalin may be accompanied by increased excitability. If you suspect an overdose the stomach should be washed and to take a few tablets of activated charcoal Activated carbon - old but indispensable .

Duspatalin data on the interaction with other drugs manufacturers are not provided.

Duspatalin - a drug that actively removes the increased motor activity of smooth muscles of the digestive system, while not inhibiting their normal motility.

Galina Romanenko

Creon - instructions for use of the enzyme preparation contains detailed information about its mechanism of its action, indications and contraindications, side effects and storage conditions. Sold most dosage forms Creon without a prescription. Only high doses of this drug requires a prescription.

The mechanism of action of Creon

Active ingredient is a pancreatin Creon - pancreatic juice, which is composed of enzymes that break down proteins, fats and carbohydrates. Creon is a special feature of its formulation. Creon is available as capsules for oral administration of different dosages. After ingestion of the capsule rapidly dissolve at the junction of the stomach into the intestine, releasing a plurality of microcapsules which are mixed with the contents of the stomach and move with it into the duodenum. Microcapsules (microspheres) coated with enteric-coated so dissolve in the intestine, releasing enzymes that help to break down fats, carbohydrates and proteins (lipase, amylase, protease). The process of digestion of food is improving, then it is completely absorbed into the bloodstream. Availability pancreatin microsphere allows better mixed with food, which enhances the effectiveness of the drug.

Auxiliaries, members of Creon capsules Creon - medicine to help digestion   are macrogol 4000, hypromellose phthalate, 1000 dimethicone, cetyl alcohol, triethyl citrate. The composition of the capsule shell include gelatin, yellow iron oxide, red iron oxide, titanium dioxide, sodium laurylsulphate. Creon capsules are produced with different doses of pancreatin: Creon 10000 contains 150 mg pancreatin Creon 25 000 - 300 mg, Creon - 40 000 - 400 mg. Manufacturer Creon - international pharmaceutical company Abbott Products.

Indications and contraindications

Creon is used as replacement therapy in reducing or total disruption of the digestive secretion of pancreatic juice in the following diseases and conditions:

• cystic fibrosis - a serious hereditary disease affecting the pancreas and the almost complete absence of its functions;
• chronic pancreatitis - inflammation of the pancreas, a gland in which cells are gradually replaced by connective tissue with decreased function of the body;
• state after removal of the pancreas;
• pancreatic cancer;
• ductal obstruction of the pancreas or common bile duct (in a flow duct carrying pancreatic juice and bile);
• Shvahmana Diamond syndrome - a hereditary disease, which interferes with the function of the pancreas and bone marrow;
• reducing the function of the pancreas Diabetes and pancreas - the things you need to know   in elderly patients.

In addition, Creon take to improve the digestive process in violation of the other digestive organs in the following diseases and conditions:

• state after removal of the gallbladder (cholecystectomy);
• state after complete or partial removal of the stomach;
• state caused by stagnation of food in the stomach and duodenum (gastrostasis, duodenostasis);
• obstruction of bile ducts (biliary obstruction);
• hepatitis on a background of stagnation of bile (cholestatic hepatitis);
• cirrhosis of the liver;
• diseases end of the small intestine;
• bacterial overgrowth in the small intestine.

Contraindications receiving Creon in acute pancreatitis, exacerbation of chronic pancreatitis, hypersensitivity to pancreatin of porcine origin and the other components of the drug.

With caution and only as directed Creon prescribed during pregnancy and nursing Breastfeeding - a personal choice   feeding.

Side effects of Creon and his possible overdose

Creon is well tolerated by patients of all ages. Because of the side effects of this drug note the following manufacturers:

• from the gastrointestinal tract - nausea, vomiting, abdominal pain Abdominal pain: Types and Symptoms Constipation or diarrhea;
• allergic reactions such as skin rash.

Moreover, in cystic fibrosis patients treated with high doses kreon long time, can develop colitis and stricture ileum and cecum. However, the exact relationship between the development of such a complication, and taking Creon finally installed.

With an overdose of Creon in the blood and urine may appear an excess of uric acid salts (urate), so long-term use at high doses Creon may be complicated by the formation of kidney stones.

Creon - a modern efficient enzyme preparation, which is applied, as in the human pancreas and digestive problems associated with other diseases of the gastrointestinal tract.

Galina Romanenko